ID W5QCK9_SHEEP Unreviewed; 687 AA.
AC W5QCK9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Transmembrane protein 214 {ECO:0008006|Google:ProtNLM};
GN Name=TMEM214 {ECO:0000313|Ensembl:ENSOARP00000020456.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000020456.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000020456.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000020456.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000020456.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Critical mediator, in cooperation with CASP4, of endoplasmic
CC reticulum-stress induced apoptosis. Required or the activation of CASP4
CC following endoplasmic reticulum stress.
CC {ECO:0000256|ARBA:ARBA00024938}.
CC -!- SUBUNIT: Constitutively interacts with CASP4; required for the
CC localization of procaspase 4 to the ER.
CC {ECO:0000256|ARBA:ARBA00011720}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM214 family.
CC {ECO:0000256|ARBA:ARBA00007984}.
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DR EMBL; AMGL01075860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5QCK9; -.
DR STRING; 9940.ENSOARP00000020456; -.
DR PaxDb; 9940-ENSOARP00000020456; -.
DR Ensembl; ENSOART00000020738.1; ENSOARP00000020456.1; ENSOARG00000019049.1.
DR eggNOG; KOG4467; Eukaryota.
DR OMA; NGSAGKW; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000019049; Expressed in pituitary gland and 53 other cell types or tissues.
DR ExpressionAtlas; W5QCK9; baseline.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR019308; TMEM214.
DR PANTHER; PTHR13448; TRANSMEMBRANE PROTEIN 214; 1.
DR PANTHER; PTHR13448:SF0; TRANSMEMBRANE PROTEIN 214; 1.
DR Pfam; PF10151; TMEM214; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 77203 MW; 00653E4C549913EB CRC64;
MAAKTAGGGR WEVVKKGRRA GDSAGGPLEP MNSRAVGTER SHQEGSLSTP IQTTSTLYER
GFEKIMKRQN KEQVPPPAVE PKKPGNKKQA KKVATLTNQN QKQGRFRSLE EALKALDLAD
LQKELDKSQS VFSGNPSVWL KDLASYLNYK LQVPPSEPTL SQHPHDYPYS LVSRELRGII
RGLLAKAAGS LELFFDHCLF TMLQELDKTP GESLHGYRIC IQAILQDKPK IVTTNLGKFL
ELLRSHQSRP AKCLTIMWAL GQAGFTNLTE GLRVWLGIML PVLGIKSLSP FAIAYLDRLL
LMHPNLTKGF GMIGPKDLFP LLDFAYMPNN SLTPSLQEQL CQLYPRLKVL AFGAKPESTL
HTYFPSFLSR ATPGCPPEMK KELLRSLTEC LMVDPLSTSV WRQLYPKHLS QSSLLLEHLL
RSWERIPKKT QKSLQETIQS FKLTNQDLLR KGSGSNQDVV TCDSACKSLL QQARGFQLPW
TRLLLLVLVF AIGFLCHDFR SHSSFQASLS GRLLQSSGIL PAGQQACTKI YSYSLQGYSW
LEKTLPAWGS HLLTVVRPGL QLAWAHTNAT VSFLSAHCAS HLAWFSDSLA NLFQRVQTQL
PDTLNQLVRS LRELLLFLYH SILLPTWHML LEALAQIQEH CHEACRGEVT WDCMKTQLSE
AAHWTWLRLQ DTTVAFLDWA LAMISQQ
//
