ID W5QI71_SHEEP Unreviewed; 519 AA.
AC W5QI71;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Antizyme inhibitor 2 {ECO:0008006|Google:ProtNLM};
GN Name=AZIN2 {ECO:0000313|Ensembl:ENSOARP00000022422.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022422.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000022422.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000022422.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000022422.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
CC {ECO:0000256|RuleBase:RU003737}.
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DR EMBL; AMGL01056693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01056694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01056695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01056696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01056697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5QI71; -.
DR SMR; W5QI71; -.
DR STRING; 9940.ENSOARP00000022422; -.
DR PaxDb; 9940-ENSOARP00000022422; -.
DR Ensembl; ENSOART00000022728.1; ENSOARP00000022422.1; ENSOARG00000020862.1.
DR eggNOG; KOG0622; Eukaryota.
DR HOGENOM; CLU_026444_1_1_1; -.
DR OMA; FTCYSVK; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000020862; Expressed in testis and 24 other cell types or tissues.
DR GO; GO:0016831; F:carboxy-lyase activity; IEA:UniProt.
DR GO; GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00622; PLPDE_III_ODC; 1.
DR Gene3D; 3.20.20.10; Alanine racemase; 1.
DR InterPro; IPR009006; Ala_racemase/Decarboxylase_C.
DR InterPro; IPR022643; De-COase2_C.
DR InterPro; IPR022657; De-COase2_CS.
DR InterPro; IPR022644; De-COase2_N.
DR InterPro; IPR022653; De-COase2_pyr-phos_BS.
DR InterPro; IPR000183; Orn/DAP/Arg_de-COase.
DR InterPro; IPR002433; Orn_de-COase.
DR InterPro; IPR029066; PLP-binding_barrel.
DR PANTHER; PTHR11482:SF4; ANTIZYME INHIBITOR 2; 1.
DR PANTHER; PTHR11482; ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE; 1.
DR Pfam; PF02784; Orn_Arg_deC_N; 1.
DR Pfam; PF00278; Orn_DAP_Arg_deC; 1.
DR PRINTS; PR01179; ODADCRBXLASE.
DR PRINTS; PR01182; ORNDCRBXLASE.
DR SUPFAM; SSF50621; Alanine racemase C-terminal domain-like; 1.
DR SUPFAM; SSF51419; PLP-binding barrel; 1.
DR PROSITE; PS00878; ODR_DC_2_1; 1.
DR PROSITE; PS00879; ODR_DC_2_2; 1.
PE 3: Inferred from homology;
KW Polyamine biosynthesis {ECO:0000256|ARBA:ARBA00023115};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 47..281
FT /note="Orn/DAP/Arg decarboxylase 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02784"
FT DOMAIN 282..388
FT /note="Orn/DAP/Arg decarboxylase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00278"
FT REGION 457..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 55819 MW; 577D89914301A963 CRC64;
MAGYLRETDF VMVEEGFSTR DLLEELTLGA SQATAEEVAA LFVADLGAVV RKHFCFLKCL
PRVRSFYAVK CNSSPGVLKV LAELGLGFSC ANKAEMELVQ DIGVPASKII YANPCKQIAH
IKYAAKHGVR LLSFDNEMEL AKVVKSHPSA KMVLCIATED SHSLSRLSLK FGASLKSCRH
LLENAKRDHV EVIGVSFHIG SGCPDPQAYA QSIADARVVF EMGAELGHRM HILDLGGGFP
GVEDAKVRFE EIASVINSAL DLYFPEGCGV DILAKLGRYY VTSAFTLAIS IIAKKEVLLD
QPGREEETGS SPKSIVYHLS EGVYGVFSSV LFDSTCPAPI LQKKPPTEQP LYSSSLWGPV
ANGCDCVAEG LWLPQLHVGD WLVFENMGAY TVGMGSPLRD AQTCRITYAM SRVAWEALPG
QHRPPAPPAA CRTGRGCRGH VQASVLWLGD HGHLVHGPRL HPGEHHVSGP RSPPENPSGA
PEMPLGEVGK VASRAPSGQD SGARSATPHA PPVVFLPCK
//
