ID W5QI84_SHEEP Unreviewed; 226 AA.
AC W5QI84;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Transmembrane protein 54 {ECO:0008006|Google:ProtNLM};
GN Name=TMEM54 {ECO:0000313|Ensembl:ENSOARP00000022436.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022436.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000022436.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000022436.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000022436.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM54 family.
CC {ECO:0000256|ARBA:ARBA00011030}.
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DR EMBL; AMGL01056714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004005059.2; XM_004005010.3.
DR AlphaFoldDB; W5QI84; -.
DR STRING; 9940.ENSOARP00000022436; -.
DR PaxDb; 9940-ENSOARP00000022436; -.
DR Ensembl; ENSOART00000022742.1; ENSOARP00000022436.1; ENSOARG00000020874.1.
DR eggNOG; ENOG502S0UN; Eukaryota.
DR HOGENOM; CLU_089663_1_0_1; -.
DR OMA; QISHECP; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000020874; Expressed in descending colon and 52 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR020977; Beta-casein-like.
DR PANTHER; PTHR31258; KERATINOCYTE-ASSOCIATED PROTEIN 3; 1.
DR PANTHER; PTHR31258:SF2; TRANSMEMBRANE PROTEIN 54; 1.
DR Pfam; PF12304; BCLP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 202..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 226 AA; 23955 MW; C40BFDA81BF40A72 CRC64;
MALMWLSLPG GLSVGDFRKV LMKTGLVLVV LGHVSFIAAA LLHGTVLRYV AAPSDAVALQ
YCVVDILSVT SAIVVITSGI AVTVLSRYLP SIPLRWTVFS LSVACALLSL TCALGLLASI
AVTFATQGRA LLAACTFGGP ERLALAPDCP FDPTRIYSSS LCLWGISLLF CVAESVFAVR
SAQLAHQVLE LRPWLGKSSH RMMQESPEPV EDPDLPSRAS SGPMTL
//
