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Database: UniProt
Entry: W5QJ85_SHEEP
LinkDB: W5QJ85_SHEEP
Original site: W5QJ85_SHEEP 
ID   W5QJ85_SHEEP            Unreviewed;       510 AA.
AC   W5QJ85;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 49.
DE   SubName: Full=Regulator of G protein signaling 6 {ECO:0000313|Ensembl:ENSOARP00000022787.1};
GN   Name=RGS6 {ECO:0000313|Ensembl:ENSOARP00000022787.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022787.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000022787.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000022787.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000022787.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   EMBL; AMGL01104443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01104444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01104445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01104446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01104447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01104448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01104449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01104450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01104451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01104452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5QJ85; -.
DR   SMR; W5QJ85; -.
DR   STRING; 9940.ENSOARP00000022787; -.
DR   PaxDb; 9940-ENSOARP00000022787; -.
DR   Ensembl; ENSOART00000023102.1; ENSOARP00000022787.1; ENSOARG00000021200.1.
DR   eggNOG; KOG3589; Eukaryota.
DR   HOGENOM; CLU_025092_4_0_1; -.
DR   OMA; PWITDNT; -.
DR   Proteomes; UP000002356; Chromosome 7.
DR   Bgee; ENSOARG00000021200; Expressed in gastric lymph node and 48 other cell types or tissues.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   CDD; cd04450; DEP_RGS7-like; 1.
DR   CDD; cd00068; GGL; 1.
DR   CDD; cd08737; RGS_RGS6; 1.
DR   Gene3D; 1.10.1240.60; -; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR015898; G-protein_gamma-like_dom.
DR   InterPro; IPR036284; GGL_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR047016; RGS6/7/9/11.
DR   InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR   InterPro; IPR037956; RGS6_RGS.
DR   InterPro; IPR040759; RGS_DHEX.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45746; LP21163P; 1.
DR   PANTHER; PTHR45746:SF2; REGULATOR OF G-PROTEIN SIGNALING 6; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00631; G-gamma; 1.
DR   Pfam; PF00615; RGS; 1.
DR   Pfam; PF18148; RGS_DHEX; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM01224; G_gamma; 1.
DR   SMART; SM00224; GGL; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT   DOMAIN          26..101
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          322..437
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
SQ   SEQUENCE   510 AA;  59127 MW;  A83057D968C119B9 CRC64;
     MGRNQHSPSN EARLKDDIIT KMQDDKTGGV PVRTVKSFLS KIPSVVTGTD IVQWLMKNLS
     IEDPVEAIHL GSLIAAQGYV FPISDHVLTM KDDGTFYRFQ APYFWPSNCW EPENTDYAIY
     LCKRTMQNKA RLELADYEAE NLARLQRAFA RKWEFIFMQA EAQVKIDRKK DKTERKILDS
     QERAFWDVHR PVPGCVNTTE MDIRKCRRLK NPQKVKKSVY GVTEESQSQS PVHIPSQPIR
     KTTKEDVRKQ ITFLNAQIDR HCLKMSKVAE SLIAYTEQYV EYDPLITPAE PSNPWISDDI
     TLWDIEMSKE PSQQRVKRWG FSFDEILKDQ VGRDQFLRFL ESEFSSENLR FWLAVQDLKK
     QPLQDVARRV EEIWQEFLAP GAPSAINLDS HSYEITSQNV KDGGRYTFED AQEHIYKLMK
     SDSYARFLRS NAYQDLLLAK KKPESEQGRR TSLEKFTRSV VSSAGFLWFF GFLSVFLGGG
     CHFLREGREP SALPSAHPPM VFCECRWLLS
//
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