ID W5QJ85_SHEEP Unreviewed; 510 AA.
AC W5QJ85;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=Regulator of G protein signaling 6 {ECO:0000313|Ensembl:ENSOARP00000022787.1};
GN Name=RGS6 {ECO:0000313|Ensembl:ENSOARP00000022787.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022787.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000022787.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000022787.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000022787.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01104443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01104444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01104445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01104446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01104447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01104448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01104449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01104450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01104451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01104452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5QJ85; -.
DR SMR; W5QJ85; -.
DR STRING; 9940.ENSOARP00000022787; -.
DR PaxDb; 9940-ENSOARP00000022787; -.
DR Ensembl; ENSOART00000023102.1; ENSOARP00000022787.1; ENSOARG00000021200.1.
DR eggNOG; KOG3589; Eukaryota.
DR HOGENOM; CLU_025092_4_0_1; -.
DR OMA; PWITDNT; -.
DR Proteomes; UP000002356; Chromosome 7.
DR Bgee; ENSOARG00000021200; Expressed in gastric lymph node and 48 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR CDD; cd00068; GGL; 1.
DR CDD; cd08737; RGS_RGS6; 1.
DR Gene3D; 1.10.1240.60; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR047016; RGS6/7/9/11.
DR InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR InterPro; IPR037956; RGS6_RGS.
DR InterPro; IPR040759; RGS_DHEX.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45746; LP21163P; 1.
DR PANTHER; PTHR45746:SF2; REGULATOR OF G-PROTEIN SIGNALING 6; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00631; G-gamma; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF18148; RGS_DHEX; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00049; DEP; 1.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT DOMAIN 26..101
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 322..437
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
SQ SEQUENCE 510 AA; 59127 MW; A83057D968C119B9 CRC64;
MGRNQHSPSN EARLKDDIIT KMQDDKTGGV PVRTVKSFLS KIPSVVTGTD IVQWLMKNLS
IEDPVEAIHL GSLIAAQGYV FPISDHVLTM KDDGTFYRFQ APYFWPSNCW EPENTDYAIY
LCKRTMQNKA RLELADYEAE NLARLQRAFA RKWEFIFMQA EAQVKIDRKK DKTERKILDS
QERAFWDVHR PVPGCVNTTE MDIRKCRRLK NPQKVKKSVY GVTEESQSQS PVHIPSQPIR
KTTKEDVRKQ ITFLNAQIDR HCLKMSKVAE SLIAYTEQYV EYDPLITPAE PSNPWISDDI
TLWDIEMSKE PSQQRVKRWG FSFDEILKDQ VGRDQFLRFL ESEFSSENLR FWLAVQDLKK
QPLQDVARRV EEIWQEFLAP GAPSAINLDS HSYEITSQNV KDGGRYTFED AQEHIYKLMK
SDSYARFLRS NAYQDLLLAK KKPESEQGRR TSLEKFTRSV VSSAGFLWFF GFLSVFLGGG
CHFLREGREP SALPSAHPPM VFCECRWLLS
//