ID W5T8N3_9NOCA Unreviewed; 2019 AA.
AC W5T8N3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:AHH15685.1};
GN ORFNames=NONO_c08780 {ECO:0000313|EMBL:AHH15685.1};
OS Nocardia nova SH22a.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1415166 {ECO:0000313|EMBL:AHH15685.1, ECO:0000313|Proteomes:UP000019150};
RN [1] {ECO:0000313|EMBL:AHH15685.1, ECO:0000313|Proteomes:UP000019150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SH22a {ECO:0000313|EMBL:AHH15685.1};
RX PubMed=24747905;
RA Luo Q., Hiessl S., Poehlein A., Daniel R., Steinbuchel A.;
RT "Insights into the Microbial Degradation of Rubber and Gutta-Percha by
RT Analysis of the Complete Genome of Nocardia nova SH22a.";
RL Appl. Environ. Microbiol. 80:3895-3907(2014).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP006850; AHH15685.1; -; Genomic_DNA.
DR STRING; 1415166.NONO_c08780; -.
DR KEGG; nno:NONO_c08780; -.
DR PATRIC; fig|1415166.3.peg.885; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_2_2_11; -.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000019150; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000019150}.
FT DOMAIN 1001..1075
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2019 AA; 219531 MW; AF0C16F110CFB6FA CRC64;
MAARLAEEGL ATAAAVGPRR DAERAPLSFG QRYVWAHQQI SPGSTAYNLC LALTFEGDVD
ADALRTAFEA LVRRHEVLRT TYHTDEDGEP YQRIHTELPP RLREVDLSAA APAAARAQVR
ELTEAAARES FDLTAESSLR VTFARVHATE LVAIVVIQHI AWDGMTLPAL SRDVEEFYRQ
ARTGEVEVEP LRLQVADFAE WEADRFAADD HDEDIRFWQS RFDGELPELP LPYDRRPVAV
TERGERSDQP LSAPADAALR ELTGRLRTTP FSVFLSAYYL ALRQMTGRAD MVIGTTVANR
EESGMELLIG NLSNMLPLRI AADGDTRFAD LVEQVRGVIT DGFGHKHFPQ EGIVRAVNAA
TGNVGSSLFD TMVLFLHQKI DGPQLPGVTT SWDLMHNGAA LLPLVVETFM HTDRTDVQIT
YRTDLFDAET IDRLHEYIDQ VLAAAAPERP IDELTTLSRS DRAALSEWTH GGVVEIEADT
IDAMIRAATA KYPDRTAVVF GDLELSYREF DSRVNELARL LLARGVRSGD RVGVYAERSE
RLPIAFAAVQ RVGAVYFPVD PSYPTDRIEY MLSDAEATLL LVSAAQAPPV EITVPTVDLT
DPEIVAELAA TDSGELPSSA LQRPIHTFDG AYLLYTSGTT GRPKGVIVHQ RGVTNHVQWM
RDYLEFGEER ILQKAPIGFD VSVFELVNAL CTGSATVLPP PDWWQADVEA LAGIIHRHRI
TQISLVPSVV RAFIDAGPDP ARLQSMRYVY LGGESVPPAL VEESSRFFGG TVLGLYGPTE
GSMDLMHEDF AGIDPHEDTI RSALIGAPEW NSSVYVLDEQ LRQVPPGVVG ELYLGGVQLA
RGYHRRPDLT AAAFVACPFS DESGARMYRT GDIVRWNAQG RMEYLGRGDD QVKVRGHRIE
LGEIGTVLRR MPGIASAVAV TTPQAQGDLA LVAYYVADAE FDDDAEAIKA HLAQRLPEYM
IPSALVRLDE LPLTANGKLD RRALPAPDLG GSTGRGRALR DDAERGVADA VRQVLGIADT
TELAADDDFL ALGGDSITAI RMASALKKRG LLITTSALFD ARTIARIAAA AEPIVAGGAP
ALAEVGDDTG WIPLNPIATV LTETAPDHSA YSQATAVVTP AHSSLDQVTA VVAALVDRHP
MLRARMDTDP DGRTAYYIPG PDEQVAEPTL TEIVVPAQEW DRAAGSQLRE QLRNGSELLD
PAAGRMVAAV WVRSDDGAQG RLLLVIHHLV VDGVSWRIIH DDLRQLWENP SAAAESGTSV
KTWNTSLTGL ATADSVLATL PYWTAAAEGV DPLLGGRELD PAVDTVSTVR EITTSLDSDD
TAFLMTTATA AFGCDFLDIQ VASLAVAVHR FRQRRASDAA TVSLTMERHG RVETLFAGVD
LANTVGWFTT TYPVTLDVTG GSEVESAVKA VKEQLLAVPE SGIGWGLLRW LNPETRAALE
QFRTPQISFN YMGRFAAAGS EGEAENFSAA PEFGYMGGHA NPGMPAPALL DINTVALTED
DRVTLQASFR FPAGPLSDED VRELAELWES GLGELAKAVR DNQMRRLSPS DVLAVGPNQL
DLDRWHDIYG EFEDVYPLAP MQAGLYLTAL SAGARDVYNV QTLISVRGDL DVPRLGRAFD
TVLNRYPNLR VTLSVSHAGR PYAIVSGHMP IPVREIDLST VSDATARLHE FYRADQAEQF
DLTHGPLTRV TVVHMPDGVH TVVLTMHHML LDGWSGQLVA REVFAEYAVA GADPIATPET
FGKFLAMVEA GQEAVEAAWQ PVLEGVQPCI VAPGRGLGSD GIPVERSFVI DDDLVDRLTA
LASDVGTTFS VVCQLAWANA LRYVAGEDTT VFGEAVSGRP ADLDEVDNAI GCFANIIPAV
IGFSGDRTWR EHLSEVQSRR RELMEYHSYP LTSALRAAGS RKLFDTMFVF ESYPPGRKEL
EGLLGSAGLE LASFEGAGAT DNALLLMIFP ANSLLPSDSV QAAIFYAEDA FEADDARIIE
TAFSGTLRAI AESPDQPIST VPVLDDEDQG LLVMRRMWQ
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