ID W5TBB6_9NOCA Unreviewed; 1204 AA.
AC W5TBB6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=NONO_c14650 {ECO:0000313|EMBL:AHH16268.1};
OS Nocardia nova SH22a.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1415166 {ECO:0000313|EMBL:AHH16268.1, ECO:0000313|Proteomes:UP000019150};
RN [1] {ECO:0000313|EMBL:AHH16268.1, ECO:0000313|Proteomes:UP000019150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SH22a {ECO:0000313|EMBL:AHH16268.1};
RX PubMed=24747905;
RA Luo Q., Hiessl S., Poehlein A., Daniel R., Steinbuchel A.;
RT "Insights into the Microbial Degradation of Rubber and Gutta-Percha by
RT Analysis of the Complete Genome of Nocardia nova SH22a.";
RL Appl. Environ. Microbiol. 80:3895-3907(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP006850; AHH16268.1; -; Genomic_DNA.
DR AlphaFoldDB; W5TBB6; -.
DR STRING; 1415166.NONO_c14650; -.
DR KEGG; nno:NONO_c14650; -.
DR PATRIC; fig|1415166.3.peg.1491; -.
DR eggNOG; COG0210; Bacteria.
DR eggNOG; COG2887; Bacteria.
DR HOGENOM; CLU_004900_0_0_11; -.
DR Proteomes; UP000019150; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000019150}.
FT DOMAIN 20..337
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 338..756
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 510..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 41..48
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1204 AA; 128492 MW; 494D9B1B2C836D6D CRC64;
MRLVRRSETA PRPREWGADV RTLFAGGSGA DTGWRPWHVL GGPGTGKTAL LTDLAVDRIL
AAVDPESVLI LTHSKQAALR VRTALTRQLS AVAPELGGVP GVSREPMVRT VHSYAFSILR
THATSRGNPP PRLLTGAEQD VVLREMLRGE LSDIRAGEDA LWPQRLHAAL GTDGFAEQLR
DLMLRATERD LGPEDLVDLG RLHDRAEWEA AGSFALRYEQ TMLLRWSVGV QAPEASAPAL
DAAELVGAAL DVLIEDEDLL AAERERVRLL LVDDAQHVDP LAAQLIRAIG SGPSTTVIAG
DPDQAIFSFR GADTRFVTEP DAPPERRIVL HDDHRCAPAV HAAVTRVAAR MPGRAPHRFT
ARSGQLLGDP VVDGQVQVRV LTTPAKEAAV IADQLRRAHL TAEVPWSRMA VVVRSVPLSL
GPLRRALTAA GVPVLQPKPD TPLARRRGAA WMLQSLRALL VAERDRPELF TEDDALDLLL
GPLGGADQIS LRRLRRGVRR AIIARGYRVP DTESAGDGAG RSGGTEEPRE PLGDAGSSGY
ADPVPPGEVT GDHPESRTGT GGSADPAGLA ATSSEPGPDS GGEPDRPAQG SATARGATVP
DEVGLAPYSE LDRSSAVVLR DLITGVGDRS LLQQLTEVEA APLIRVLKAV DRARRVLRRG
AGVEDVLWAL WTASRLEKRW VAQSERGGPG AVQADRDLDA AVGLFDAAAT YVDRLPGAAA
DGFVEYLEQQ EINQDSAPLT EPGDAVAIVS AHAAAGREWD VVAVAGVQEG IWPNLRSRGT
LLGVEELVDL VDGVADPGEQ ISRSAPILAE ERRLLLLACS RARHSLLVTA VESVTGDRDL
VPSRFLAELD PEAAPGEPGH IPAPADPGRA LVAQALIAEL RGVVCDESGD PDRRERAATQ
LARLARAGVR GAHPDEWYGT AAQSCELALW DDGDGPVALS PSTVELLKTC PLRWALERHG
GDDGDNPHAV KGNLVHTLVQ ALAGRVTEEQ VKAALVKAWK AVDPSSGDDG PRSWHSRLEL
QRTETMVDTF LAWLRNSRDE LAEVGVEVPV DCVLPARDPD EVPVRIRGRV DRVERDAQGR
FVIVDIKTGK TPISKQSAQD HAQLATYQVA AGAGALSAEV DGQTVEPGGA RLVYVAKPSR
GSATERVQTA LDEEGITQWR KTVHEAAAAT RGPGFLAMRN DGCRHCRVAG SCPVQDAGRQ
VTDP
//
