ID W5U8H6_ICTPU Unreviewed; 968 AA.
AC W5U8H6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 22-FEB-2023, entry version 35.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL1A {ECO:0000313|EMBL:AHH37864.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH37864.1};
RN [1] {ECO:0000313|EMBL:AHH37864.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH37864.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR EMBL; JT407116; AHH37864.1; -; mRNA.
DR AlphaFoldDB; W5U8H6; -.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF53; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT REPEAT 48..80
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 81..113
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 176..208
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 238..336
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 524..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 435..462
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 804..824
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..925
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 968 AA; 109294 MW; E6E01F24208CB6D8 CRC64;
MEELDPEEHF LRDARNGNLP GIQSLLMSKI KEETKFDINC KGKNRSNFGW TALHLSCYFG
HKDVVEELLK AGADANLTNN VGDTPLHKAA FTGRQEVVML LLQYDACPSV INGSAQIPKD
ITHDEEIRSM LEAAERTEER KLEEQMLEAA REGATTTLLK LLNREKPPNI NCTDLLGNTP
LHCAAYRGQK HCAVKLLQNG ASPNIKNKNG QTVFDLAKDT EMRQILEGSL MKGPRRYVQM
FDGPLWKSTR FFGWRSCWVV LQDGVLSWYS KQSDAASNSQ SKGCKALTQA QCSTKDSCYF
TVKCFDDSVH YFKVSPKGDP ETTRKKWLDA IEAHSAFSTH YCSQDQDSEE DEDEVISLGE
LMESLQQAEV CHGKLESEVL SLLSMVKEDL LGEGLPVAVL QKLRMVCEAS SKTCTSLRQC
LDLFSKQEGT RSLKLEQEVE KNKILSEALQ TLATEHHELE RSVVRCSSPR SAILSEDDFY
DALSYSDSEH SHNCLELSCS FKEGDEGRSE LYYSVPSCLT GGTMSQEDWR GDEEDEGAKP
NGTKKHRTSL PAPMFSRNNF SIWSILRKCI GMELSKITMP VIFNEPLSFL QRLTEYMEHT
YLIQQANDST DPIERMKCVA AFAVSAVASQ WERTGKPFNP LLGETYELVR EDLGFRVISE
QVSHHPPVSA FHAEGLEKDF VFHGSIYPKL KFWGKSVEAE PKGIMTLELP KCNEAYTWTN
PTCCVHNIIV GQLWIEQYGN VEVINHRTGE KCCLSFKPCG LFGKELHKVE GYILDKSKKK
VCVLYGKWTE CMYAVDPATF EAHKKNDKAT DGKKSSKEGS SAESEESEQP GGDSVEEIPG
SQLLWKIKPR PANSAQMYSF TSFAMQLNEL DEDIEAVIPK TDCRLRPDIR AMENGDIDLA
SEEKKRLEEK QRAARKSRAK SDMDWKTRGS ASGPRWFHQG PNPHTNSPDW LFSTSYWNRD
YSQVPDIY
//
