ID W5U9E8_ORFV Unreviewed; 638 AA.
AC W5U9E8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Nucleoside triphosphatase I {ECO:0000256|ARBA:ARBA00016931};
DE EC=3.6.1.15 {ECO:0000256|ARBA:ARBA00012445};
DE AltName: Full=Nucleoside triphosphate phosphohydrolase I {ECO:0000256|ARBA:ARBA00031272};
GN Name=NPH1 {ECO:0000313|EMBL:QJX15492.1};
GN ORFNames=01orf_00065 {ECO:0000313|EMBL:QJX15492.1};
OS Orf virus (ORFV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Parapoxvirus.
OX NCBI_TaxID=10258 {ECO:0000313|EMBL:AHH34261.1, ECO:0000313|Proteomes:UP000356155};
OH NCBI_TaxID=9925; Capra hircus (Goat).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9940; Ovis aries (Sheep).
RN [1] {ECO:0000313|EMBL:AHH34261.1, ECO:0000313|Proteomes:UP000356155}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B029 {ECO:0000313|EMBL:AHH34261.1,
RC ECO:0000313|Proteomes:UP000356155};
RX PubMed=24373950; DOI=10.1016/j.virusres.2013.12.015;
RA Friederichs S., Krebs S., Blum H., Wolf E., Lang H., von Buttlar H.,
RA Buttner M.;
RT "Comparative and retrospective molecular analysis of Parapoxvirus (PPV)
RT isolates.";
RL Virus Res. 181:11-21(2014).
RN [2] {ECO:0000313|EMBL:QJX15492.1, ECO:0000313|Proteomes:UP000502189}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TVL {ECO:0000313|EMBL:QJX15492.1,
RC ECO:0000313|Proteomes:UP000502189};
RA Heare D., Little S.V., Konganti K., Hillhouse A., Lawhon S.D.;
RT "Whole-Genome Sequence of Orf Virus Derived from Cell Culture Infected with
RT Contagious Ecthyma Vaccine.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-
CC diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15;
CC Evidence={ECO:0000256|ARBA:ARBA00001491};
CC -!- SIMILARITY: Belongs to the helicase family. NPH I subfamily.
CC {ECO:0000256|ARBA:ARBA00010677}.
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DR EMBL; KF837136; AHH34261.1; -; Genomic_DNA.
DR EMBL; MN454854; QJX15492.1; -; Genomic_DNA.
DR Proteomes; UP000356155; Genome.
DR Proteomes; UP000502189; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0017111; F:ribonucleoside triphosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR013676; NPHI_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000330; SNF2_N.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF08469; NPHI_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:QJX15492.1};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 43..205
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
SQ SEQUENCE 638 AA; 70966 MW; 6772EE48C675C972 CRC64;
MTSAHAAYID YALRRTAHMP SEMQGVEESV RLKDYQLFVA RVFLGLDSMH SLLLFHETGV
GKTVTAVYVL KHLRDVFTDW TVVVLVKKAL VEQPWTSTMM RFAPEAVPGC TFINYDDPRF
HHRFFTLMKT ASSSSRVCVV IDEFHNFISM SLTKEDGRQR PARTVYNYLA KNIPMGRGKL
LCLTATPVVN SVKEFSMAVN LLRPGVVGQT PLFNGGALAN PEDLVDKLGG LCSYLVTNEA
SIFDDVDGSA AFARKRVRMM YVDMTAKQTE AYRRAAAMER KSGAAVFRVY RRIAATFAFA
DAPDKSVLSK QEYDEAVAAL FLDFARAVKD RVFSEAAMRL FRSGAPVSGD RMTSADVSLL
AELRERSCKY TEVCLRILAS PGKCLVFEPF VNVTGIEMLL LYFRAFGVSS VEFSSRTRDT
RAKLVDAFNA CDNTDGEKIK VCVFSLSGSE GLSFLSINDI FILDMTWNEA SLRQIVGRAV
RLNSHEMTPP DRRYVNVHFV VARQDSGAAT VDEDLLALIR DKSRQFTQLF RVLKRCSLEW
VREAFTDFAP LEDDSGWSAL VARPADARGP ARAARLADGQ SVWYSTSTAL VTVRKGFLER
GGRLFDDDGN FLTALGDPPT VRVSGGRLVY VVDPASIA
//
