ID W5UCS5_ICTPU Unreviewed; 986 AA.
AC W5UCS5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN Name=MAN2B1 {ECO:0000313|EMBL:AHH39379.1};
GN Synonyms=man2b1 {ECO:0000313|RefSeq:XP_017314503.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH39379.1};
RN [1] {ECO:0000313|EMBL:AHH39379.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH39379.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_017314503.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017314503.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR EMBL; JT411314; AHH39379.1; -; mRNA.
DR RefSeq; XP_017314503.1; XM_017459014.3.
DR STRING; 7998.ENSIPUP00000004064; -.
DR Ensembl; ENSIPUT00000004258; ENSIPUP00000004064; ENSIPUG00000002847.
DR GeneID; 108259485; -.
DR KEGG; ipu:108259485; -.
DR CTD; 4125; -.
DR OMA; LEFIWRP; -.
DR OrthoDB; 5474711at2759; -.
DR Proteomes; UP000221080; Chromosome 27.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10810; GH38N_AMII_LAM_like; 1.
DR Gene3D; 2.60.40.1360; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 2.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR048534; Man2a1-like_dom.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF3; LYSOSOMAL ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR Pfam; PF21260; Laman-like_dom; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199}; Signal {ECO:0000256|RuleBase:RU361199};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT CHAIN 24..986
FT /note="Alpha-mannosidase"
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT /id="PRO_5013540152"
FT DOMAIN 368..447
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 986 AA; 111280 MW; 690D24373905DF2E CRC64;
MAADRLFPLA GFLLLCSAAG VWCFPSLREP VCGYKSCPAT KPSMLNVHLV PHTHDDVGWL
KTVDQYYYGG RNNIQHAGVQ YILDSVVSEL QKDPARRFIY VETAFFYRWW KQQDQQTRNI
VTQLVEQGRL EFVNGGWCMS DEASTHYSAV IDQMTLGLRF LNDTFGDCGR PRVAWHIDPF
GHAREHASMF AQMGYDGLFF GRLDYQDKAR RMKMQEMEMV WRASESLEPP TADLFTGVLP
NGYNPPDGFC WDQSCSDAPV QDDPDLEDYN VDQLVDAFIN LSGVQAEKYK TNHIIMTMGS
DFQYENAIPW YKNMDKLIHY VNARQVQGSR VHVLYSTPSC YLQELNLANF TWPLKTDDFF
PYADAAHDFW TGYFTSRPAL KRYERLSNSF LQTCNQLEVL GGLKSTHGPF GEGNSDTLKR
AMAVAQHHDA VSGTEKQHVA DDYAKRLAIG SAHCQVLVSN SLAFLSGSEV PRVFCENLNI
SACPLTESSK QFLLNVYNPL ARPVSWSVHL PVNGTVYNVT DSDGAPVDNQ VIPVSKATRA
LRRDRGSAQF ELVFQVQAPS MGFNTYTVTL LKNSPAPASI KPVAPPSIQN KYLKVTFDTQ
TGLVSGLTNL ETQQTIKLTQ NFYWYNASVG NSESLQPSGA YIFRPNSSTP VIINTKPEVT
TLQNSVVQEV RQQFSPWVSQ VIRLYTESKH LELEWTVGPI PVNDGFGKEV ITRLDSSIET
EGYFYTDSNG REILQRRKDY RPTWDLKQTE PIAGNYYPIN TRAFIKDEQN QMTVVTDRSQ
GIGSIYNGSL EIMVHRRLLR DDNRGVAEPL SEPGEYYDGL AVRGRLLLAL TPPSTAADTH
RPLGQEMVFQ PTLSFQQGAT HSTTPQFSGL ISALPPAVHV LTLSQWDQDS VLLRLEHQYE
RSESHAHSQP ITISLQKLFS TLDVVGVSEM SLGANQWKED MKRMQWKPDS GETAVPLHEH
VGDPSSWEIT LNPMEIRTFL LRVRHK
//