ID W5UDJ5_ICTPU Unreviewed; 621 AA.
AC W5UDJ5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Calpain-8 {ECO:0000313|EMBL:AHH40101.1};
GN Name=CAPN8 {ECO:0000313|EMBL:AHH40101.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH40101.1};
RN [1] {ECO:0000313|EMBL:AHH40101.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH40101.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
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DR EMBL; JT413074; AHH40101.1; -; mRNA.
DR AlphaFoldDB; W5UDJ5; -.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF280; CALPAIN-12; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 2: Evidence at transcript level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239}.
FT DOMAIN 35..333
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT REGION 397..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 92
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 250
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 274
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 621 AA; 69702 MW; C72A473C16E84252 CRC64;
MSDSASDPGS ITNPMKFKNQ DFVSLRDECL QSGKLFVDPS FTADQNSIGM PADPDPKMAI
KWLRPKEISS NAVFVEGTTG TTDICQGQLG NCWLLASLSC LTMHPTLFEK VVPSGQTMDA
SYAGIFRFRF WQYGEWVEVV VDDRLPVRGG RLLFSYSRTK NEFWSALVEK AYAKLIGSYN
SLKGGNISEG MEDFTGGIAY TRPVSSRTPP VLWRTLTAAL SRGSLLSCFI QAKSVKEIGS
VTPEGLVKGH AYAITATDKV HKKAEEVLLV RLRNPWGFVE FCGPWSDKSK VWDGIDSAEK
TRIKLNIEED GEFWIGVQDF CKLFDTVELC SVEPDSDAGE EGNATDISSW SLTSHKGSWV
PMCSAGGSRK NARTFCKNPQ FHLVLSQQDV EDVELDEDDL DGRDDDDDGA AAQAKSSVDK
HKEKIKKCTV LIELLQKDRR LKDKVNFLYI GYHIYKVPPE LQDSTGSFSQ AFFDANPLVG
RSGQYRNVRA VWRKVHLDPG HYIIVVSTQR PNQPGVFFLR IYAKKGNTLG VREITCPTAF
TTTVMSNPPS PEDQRMVQKW FDEQAGPDDK LNALEFMKLL NTGLRILTLI LVYHKLWIKY
IHQNEFMIFL LSSIDVDPWP K
//
