ID W5UJZ5_ICTPU Unreviewed; 1068 AA.
AC W5UJZ5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Myosin Ic, paralog b isoform X2 {ECO:0000313|RefSeq:XP_047017148.1};
DE SubName: Full=Unconventional myosin-Ic {ECO:0000313|EMBL:AHH42479.1};
GN Name=MYO1C {ECO:0000313|EMBL:AHH42479.1};
GN Synonyms=myo1cb {ECO:0000313|RefSeq:XP_047017148.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH42479.1};
RN [1] {ECO:0000313|EMBL:AHH42479.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH42479.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_047017148.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_047017148.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, stereocilium membrane
CC {ECO:0000256|ARBA:ARBA00004289}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; JT417700; AHH42479.1; -; mRNA.
DR RefSeq; XP_017346426.1; XM_017490937.1.
DR RefSeq; XP_047017148.1; XM_047161192.2.
DR STRING; 7998.ENSIPUP00000034511; -.
DR Ensembl; ENSIPUT00000035863; ENSIPUP00000034511; ENSIPUG00000023174.
DR Ensembl; ENSIPUT00000035874; ENSIPUP00000034520; ENSIPUG00000023174.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000221080; Chromosome 17.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0060171; C:stereocilium membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF255; UNCONVENTIONAL MYOSIN-IC; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 1.
PE 2: Evidence at transcript level;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}.
FT DOMAIN 53..736
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 890..1064
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT REGION 613..635
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 146..153
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1068 AA; 122284 MW; 2663B7345906C07D CRC64;
MMELKIQLVP TGEIILSPGK NGESYCNCCA KAVGSDGVRA MMESALTARD RVGVQDFVLL
ENYTSEVAFI DNLRKRLKEN LIYTYIGSVL VSVNPYKELE IYTKQHMERY RGVNFYEVSP
HIYAVSDNAY RSMRTERRDQ CILISGESGA GKTEASKKVL QYYAVTCPAS EQVQTVKDRL
LQSNPVLEAF GNAKTLRNDN SSRFGKYMDI QFDFKGAPVG GQILNYLLEK SRVVHQSNGE
RNFHIFYQLL EGGEEDLLRR LGLERNAQQY QYLVKGNCPK VSSINDRSDW KVVRKALSVI
GFSDDEVEDL LNIIASVLHL GNIQYGSEDG GNAYITVDIQ IKYLARLLGV DGCILKEALT
HKKITAKGEE LMSPLNQEQA SSARDALSKA IYGRTFTWLV NKINTSLAFK EDFFSGKNMS
VIGLLDIYGF EVFQNNSFEQ FCINYCNEKL QQLFIELTLK SEQEEYEAEG ITWEPVQYFN
NKIICDLVEE KFKGIISILD EECLRPGDAT DLTFLEKLEG TLAGHAHFLT HKLADGKTRK
VMGRDEFRLL HYAGEVNYNV HGFLDKNNDL LFRNLKEVMC MSENKILTQC FDREELTDKK
RPETTATQFK NSLAKLMEIL MSKEPSYVRC IKPNDAKQAG RFDDVLIRHQ VKYLGLMENL
RVRRAGFAYR RRYEIFLQRY KSLCPDTWPS WDGRLVDGVS TLVRHLGYKP EEYKLGRTKI
FIRFPKTLFA TEDALEVRKH SLATKLQANW KGCCQKSKYR KMRRSAILIQ AWWRGILARR
RARGRRQAAD TIRRFIKGFM YRHQPRCPEN EYFLDYVRYS FLMKLHRSLP KSVLDKSWPT
PPPALTEASE HLRKLCMQNM VWKYCKSINP EWKHQLEQKS VASEIFKDKK DNYPQSVAKL
FVGTRLNGED INPKVLQALG SEKMKYAVPV TKYDRRGYKP RSRQLLLTCS SAVIVEETKL
KQRIDYSTLK GISVSSLSDG IFVLHVACED NKQKGDAVLQ SDHVIETLTK VAICAEKINS
INISQGSITF TVSQGKEGMI DFTSGSELLI AKAKNGHLSV TAPRLNSR
//
