ID W5UQC2_ICTPU Unreviewed; 739 AA.
AC W5UQC2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Phosphatidylinositol 3-kinase regulatory subunit alpha {ECO:0000313|EMBL:AHH41763.1};
DE SubName: Full=Phosphoinositide-3-kinase, regulatory subunit 3b (Gamma) isoform X1 {ECO:0000313|RefSeq:XP_017335614.1, ECO:0000313|RefSeq:XP_047014378.1};
GN Name=PIK3R1 {ECO:0000313|EMBL:AHH41763.1};
GN Synonyms=pik3r3b {ECO:0000313|RefSeq:XP_017335614.1,
GN ECO:0000313|RefSeq:XP_047014378.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH41763.1};
RN [1] {ECO:0000313|EMBL:AHH41763.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH41763.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_017335614.1, ECO:0000313|RefSeq:XP_047014378.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017335614.1,
RC ECO:0000313|RefSeq:XP_047014378.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
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DR EMBL; JT415611; AHH41763.1; -; mRNA.
DR RefSeq; XP_017335614.1; XM_017480125.3.
DR RefSeq; XP_047014378.1; XM_047158422.2.
DR STRING; 7998.ENSIPUP00000008805; -.
DR Ensembl; ENSIPUT00000009186; ENSIPUP00000008805; ENSIPUG00000005932.
DR GeneID; 108272037; -.
DR KEGG; ipu:108272037; -.
DR CTD; 100000252; -.
DR OrthoDB; 2880119at2759; -.
DR Proteomes; UP000221080; Chromosome 11.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd12925; iSH2_PIK3R3; 1.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000313|EMBL:AHH41763.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000313|EMBL:AHH41763.1}.
FT DOMAIN 3..77
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 120..306
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 342..437
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 635..729
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 451..485
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 739 AA; 83866 MW; 83BA2D6B973F6361 CRC64;
MSSDSFQYRA LYEYKRERGD DISLQPGDLL TVSKLAILTP DYQEGDEKNP AGWLHGTNER
TKEKGNFPGT FVEYVGVVRV GLPAGKPWPR PVPPTPGGPQ TPVGPQPPGA CASGGCGLGD
SLEQCTVPDQ APAVVLRLIE ALERPGWENE PLYRTLLASS APLDLQQALD TDPAAVDCEQ
YDLAVLADTL RAYLQELPCP IIPSVLYSEL VYTAQEIASL EDCGQQLKRI LDSPSMPQSN
HQLLVYLTRH LSKVTQSGGA AQASARFLSQ AYIELVFKHS HFSTDVNPDH HVKILEALIV
VGGLSEMQAA PALPPKPAKP MTPVNSNGVK EAAGSSLQEA EWYWGDISRE EVNDKLRDMP
DGTFLVRDAS TKMQGDYTLT LRKGGNNKLI KIYHRDGKYG FSDPLTFSSV VELISHYRHE
SLAQYNTKLD VKLMYPISRY QQDQLVKEDN IDAVGKKLQE YHNQYQEKSK EYDRLYDEYT
KTSQEIQMKR TAIEAFNETI KIFEEQCHTQ ERYSKEYIER FRREGNDKEI ERIMMNYAKL
KSRLGEIHES KIRLEQDLKT QALDNRETDK KMNSLKPDLI QLRKIRDQYL VWLNHKGVRQ
KRINDWLGIK NENTDDTYFV SEEDENLPHY DEKSWFVGDL NRTQAEDLLL GKPDGAFLIR
ESSKKGCYAC SVVVDGEVKH CVIYSTPRGY GFAEPYNLYS TLKDLVLHYH QTSLVQHNDS
LNVRLAYPVY AQMPSGPRR
//
