ID W5UTE5_ICTPU Unreviewed; 1043 AA.
AC W5UTE5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Integrin alpha-V {ECO:0000313|EMBL:AHH42893.1};
GN Name=ITGAV {ECO:0000313|EMBL:AHH42893.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH42893.1};
RN [1] {ECO:0000313|EMBL:AHH42893.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH42893.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU003762}.
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DR EMBL; JT418918; AHH42893.1; -; mRNA.
DR AlphaFoldDB; W5UTE5; -.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF4; INTEGRIN ALPHA-V; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 7.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT TRANSMEM 988..1010
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 25..91
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 100..162
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 165..217
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 228..282
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 283..347
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 348..407
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 411..474
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 459..616
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 617..752
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 762..977
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 1021..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1043 AA; 114768 MW; BB0109559E30DBB0 CRC64;
MGKQLIYYLY FTLSLFSVFP VTPFNLDTEK PSVFSGPQGS YFGFSVDFYS PTDKLQNILV
GAPKANTSSS SSVRERGAVY SCPWQSGGTC MQIEFDNSDN RVENGQQMEF KSSQWFGATV
RSDGEHILAC APLYQWSTYG FKEREPVGTC FLKKGSTVVE YSPCRSGSAT PEGQGFCQAG
FSADIVKNKR VVVGGPGSFY WQGQLISDDI SEVLSRFTKE LTTKYSNQMA TKSASAQYDD
SYLGYSVAVG DFNDDGVDDY VTGVPRGEKA LGYVNIFNGK NMASAVNFTG LQMAAYFGNA
VAATDINNDG RMDLLVGAPL FMERGSDGKL REVGQVYVYL SSGGFSFQPP LKLTGSEIYS
RFGSSVSSLG DLDRDGFNDV AVSAPYGGSS RQGLVYIYNG RAGGPDSQPS QILEGKWASA
SLPPSFGYAM HGAMDIDQNG YPDLVVGVFG ADKAILYRAR PVISVNSSLD ITPQILSLED
KRCALPGTTS MVSCFMVKYC LKASGKGAPS ILKFQVDLTL DRLKQKGAIK RVLFLHNRLS
QYTKFMSVTN GGTQSCEELQ AYLIDESEFR DKITPISIFM EFSLDYVSAA DKTGLQPILD
QSKPANITKQ AHILLDCGDD NICKPDLRLD VVSDQKQIYI GDDNPLTLEV TAENRGEGAY
EAELSIIIPP QADFIRGVRN SETSSRLSCA YKRENQTRVV CDLGNPMKGG TKIVAGLRFS
VHQLSEQDTS VKFDLQILSS NQYNSSSNLV TVVTKLAVLA KVEIRGASAP EQVFLPIANW
QPKENPVVED DIGPLVQHIY ELRNKGPSAF SKAMLDVEWP YRYNNGSLLY ITKYEVDGAM
NCSTDIEINP LNVTNPMYWN KNTTISGGDR TEGRARSHVH RRDLQDQRAE EDMLTLDCEK
AQCLKIKCQV GRLERGQSAI LYIYSRLAVS TFLQADVQNH SYVVKSSAAF SVIEMPYKNL
DFELPVNSTS ASLSVVWVNS ELTQPAPIWV VVVAVLAGLL LLALLIFIMY KLGFFKRVRP
PQEDGTEKEQ LQPQENGDKS TET
//
