ID   W5WAN6_9PSEU            Unreviewed;      4467 AA.
AC   W5WAN6;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN   ORFNames=KALB_4811 {ECO:0000313|EMBL:AHH98173.1};
OS   Kutzneria albida DSM 43870.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Kutzneria.
OX   NCBI_TaxID=1449976 {ECO:0000313|EMBL:AHH98173.1, ECO:0000313|Proteomes:UP000019225};
RN   [1] {ECO:0000313|EMBL:AHH98173.1, ECO:0000313|Proteomes:UP000019225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43870 {ECO:0000313|EMBL:AHH98173.1};
RX   PubMed=25301375; DOI=10.1186/1471-2164-15-885;
RA   Rebets Y., Tokovenko B., Lushchyk I., Ruckert C., Zaburannyi N.,
RA   Bechthold A., Kalinowski J., Luzhetskyy A.;
RT   "Complete genome sequence of producer of the glycopeptide antibiotic
RT   Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus
RT   of Pseudonocardiaceae.";
RL   BMC Genomics 15:885-885(2014).
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; CP007155; AHH98173.1; -; Genomic_DNA.
DR   STRING; 1449976.KALB_4811; -.
DR   KEGG; kal:KALB_4811; -.
DR   PATRIC; fig|1449976.3.peg.4844; -.
DR   eggNOG; COG1020; Bacteria.
DR   HOGENOM; CLU_223671_0_0_11; -.
DR   OrthoDB; 2378856at2; -.
DR   Proteomes; UP000019225; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 1.
DR   CDD; cd17646; A_NRPS_AB3403-like; 3.
DR   CDD; cd19543; DCL_NRPS; 2.
DR   CDD; cd19540; LCL_NRPS-like; 1.
DR   Gene3D; 3.30.300.30; -; 4.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 4.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR   NCBIfam; TIGR01720; NRPS-para261; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 5.
DR   Pfam; PF13193; AMP-binding_C; 3.
DR   Pfam; PF00668; Condensation; 5.
DR   Pfam; PF00550; PP-binding; 4.
DR   SMART; SM00823; PKS_PP; 4.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR   SUPFAM; SSF47336; ACP-like; 4.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR   PROSITE; PS00455; AMP_BINDING; 4.
DR   PROSITE; PS50075; CARRIER; 4.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019225}.
FT   DOMAIN          931..1006
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1936..2010
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2926..3000
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          4364..4438
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   4467 AA;  481243 MW;  F2451955D0448A34 CRC64;
     MTRAGLEDVL PLTPLQEGMF FLSSFDRGER DVYTVQLRFE LAGAVDAAAL RAAAQALLDR
     HANLRVAITA TGVDRPVQLV MRRVEVPFTE LHAADRAEVE AIVERDRHTR FDVETPPLIR
     FTLVHLGAEE HHLLLTHHHL LMDGWSGPLL GRDLFALYGS KGDPSVLPRV RPYRNYLAWL
     NAQDKQAARA AWSAALSEVD GPTLLAPEGL GKSPVAAERI RHSLSIEDSE SLANFARGRG
     VTLNTLVQAA WALVLGRATG RHDVVFGATV HGRPADLPGA HDMVGLFINT VPARITLRPA
     EPVGEFLRRV QSEQAGLLDH QHLGLAEIQQ LVGGRELFDS LVVFESYPVD EQELVRQQNE
     AGLDVRAVTT QDAVHYPVSL IVVPGKQLEL ACGHRADLVP VARAEQLLHS VAGVLLALAA
     NPDQAVGRLP LLPAELADTV LTSWNDTDHQ LTGATLPQLF AEQVRRTPDA PAVLAEAARW
     SFAELDEQVA RFAGALAARG VSAGDLVAVS LPRSAELIAV LYAVHRLGAA YLPIDPDYPA
     QRVQFMIEDA RPALVVTPEF LAERAEPVTR SAPVTAEHPA YVIYTSGSTG RPKGVVVPHG
     AIANRLRWFA DACRPGPADR FVQKTPISFD VSVPELFWPA YTGQPLVIAR PEGHRDPAYL
     AELVEREAVT VLHFVPSMLA AFLAEPTASR AKSLRTVLCS GEALPAEHVL RAREVLPAAN
     LVNLYGPTEA AVDVTAWDTT PEDGSRQVPI GAPVWNTRTY VLDSALRPVA PGEPGELYLA
     GTQLATGYLG RPGLTAQRFV ANPFGGGRMY RTGDLAMWNA DGTLAYLGRT DHQVKVRGFR
     VELGEVEHAL LAVSDVDSTA VIVREDTLVG YVTPQRVDTE GARRELAQSL PAHMVPSVIV
     ALEALPVTAN GKLDRAALPE PGRALGGVRR EPRTAAEQLI TELFAAVLGV PRVFADEDFF
     ALGGHSLLAI KLVAGLRSAL RVDVSPRTVF DHPTPAALAA ALDEAPAARP ALVAGPRPEF
     VPLSASQRQL WFLHRVDGPN ATYNLPLVWR LRGPLDHEAL RCALGDVAGR HEVLRTIFPD
     RDGVPYQHVL PPAPVNCPVV DATEEDLPGR LTEAVGYGFA LDSEPPMRPT LFRLGADNHV
     LVLLLHHIAG DEWSSHPLRR DLFAAYEARL RGGAPQWDVL PVQYADFALW QDDQQLITEQ
     AEFWVRELAG LPERIELPAD LSRPPVAGQH GDAVEFELPV QVAERLRELA TQSGATQFML
     AQAAVAALLH LMGAGEDIPL GTQVAGRGDS ALDELVGFFT NTIVLRTDLA GRPTFRALID
     RVRSTDLAAF AHQDLPFDRL VDRLQPQRSL AHHPLFQVGI AYQHAEVEAE RYGELTVAPH
     RVHFPVAKFD LDFEFVTLGP GRVSGAVLYR TDLFTRPAAQ RIADWLVRLL TELATNPDRP
     IASVELLSTT DRDLLLSQGR GEPFTGRRTI SELFAEAVTR YPDVDAVCGA DHALTYRQLD
     AASTELAAEL AGHGVVPGER VLVALDRGVD AVVTLLAVAK TGATYLPLAP SAPAARRAEI
     IADAEPIVEI TAGGVTALGG SSPAPSAAYL IYTSGSTGKP KGVLVSHAGV ESLVHTAVHT
     YGAGPGARVL QFTSPAFDVY LEELAMSVLS GGTLHIPGEQ ERLGAALAEF ARRHDLTHVD
     LPPAALEALP DNGLPATTTI VVGSDKVPAE LVARWSPGRE LFNAYGPTET TVNATVWACP
     ASFDGRVLIG RPDTARTLYV LDDQLRPSHT GELYVGGDAL ALGYWRAPKA TAERFVANPF
     DGGRMYRTGD RVRWTADGDV EFLGRVDAQL KIRGFRIEPA EVEAALTALP GVSLAAVVAR
     EDGGPRRLVG YVVAAEDHEP DGTELRRQLG ATLPDYLVPA AIVPLSTLPL NNSGKIDRRA
     LSTVDWSAPR ESAGRALDTE AEHAIAAAFR GVLGLTEVGA DAGFFALGGD SISSIQVVSR
     LRSSGWRITA RQVFEHQTIT ELAAVAERLE PQAAPQPRAE HGTVWPLAPL QEGLLYLNQL
     ESDVYLVQQV FTLRGELDPE LLRRCLHAML ERYPNLRAGF TLSETSRPVQ FIPERVDLPW
     QHLELSEVEF ERLLAEDRAE RFDLANPPLM RATTVRFADG THRLVLTHHH ILMDGWSGPL
     FGRELFVLYG NGGDTAVLPP APDYRDYLDW LAKQDRAETA KAWRDALSDV DDPTLVGASD
     QPVRELRLEL PEGVGELARE HGLTVNTVVQ ALWALTLAAE TGRSDVVFGT TVHGRPAELD
     GAERMVGLFI NTVPVRVRLR PEEPLAELLA RIQVEQARLL DHQHAGLADI QRAAGTGELF
     DTLVVFESYP IDDAALAEAE RQAGLAVTGL SERDETHYPL TLLVAPGERL AVTLRYRQDV
     TRFASRLRAV AEWLPQGGTT AVGRAEFLTA DERASVVHAW NDTAHEVPTA MLPELFAAQA
     ARTPQAVALV AGEGEWTYAQ FAARVHELAA AMQAQGVGPE TVVAVALPRS VDLVAALHAV
     QLCGGAYLPI DAGLPADRIE FMLADAEPAL VVTPEWLSDV DGWSAFTPVR VLPDSAAYVL
     YTSGSTGRPK GVMVSHSAIV NRLLWMAEQY GFGPDTRTLQ KTPASFDVSV WELFLPLITG
     GTLVVAGPEA HRDPAQLAAV IRSARVDTVH FVPSMLAAFL AEPSAIGLGL RRVVCSGEAL
     PADLALRARD VLGVAVHNLY GPTEAAVDVT AWDTAAEDGS RPVPIGRPVW NTRTYVLDSA
     LRPVAPGVPG ELYLAGSQLA RGYLRRSGLT AERFVANPFG GGRMYRTGDL AMWNADGTLA
     YLGRTDHQVK LRGQRIELGE VEHALRQVQD VTAAAVLVHN ESQLVGYVTG LVDGEQVRAH
     LVEHLPSAMV PAAVIVLAEL PLTPSGKLDR KALPAPDFAA HAEDLAPSGP VETAIAAAIG
     AVLDLEWVGA TADFFRLGGD SISSLQLIAR LRKAGYQLTP REVFEHRTPA ALAVIARTTG
     EAPARTSART GVVPLLPVME SLRDLGGDTS RFSQSMLLRT PAGATLPQIA SLLDAVLDAH
     DALRARLEPG WVYRIRPQGS VSAADLLRRA DQGIREEFAA AIEELDPAGG VMLRAVWFDA
     GREPGRLLLV AHHLVVDGVS WRILMDDLAE GWAAIQRGGL PALAPATTSL LDWAQALREP
     RWAEHAERWQ EVLAGNALLG NESALDPAVH KRSTVDKCSV ELPVELTEQL LTSLPAAAHA
     GVQDVLLTAL ALAVSRWRAA RGLSDADGLV IDLEGHGRDE HLVPGTDLSR TVGWFTSVYP
     ARIGGVSGDA VAWLKAVKEQ LRSLPEAITF GVLDLPDASP RTILFNYLGR LGGGAAAENW
     APAEESRLLD GSADLVTPVS HPLEINAVTV RHEEGSRLHG EFAFVRDLFS EQEIRELAEG
     WQSALAELAE SVREPFHTPS DFPLVQIDQS DVDELLGVAD VLPLSPLQEG MLFQASFDTE
     GEDVYSVAYA YDLTGPVIPA RLRAAGEALL ARHDNLRVSF RQLRSGVTVQ VVPEYVDLPW
     QVVQDVDVEQ FTTEFATSRF DLAQAPALRM ALIRISPTRH RLLLAHHHIL ADGWSGPLLA
     EELFALYGTG ALPPVRPYVE HLRWLAAQDP SAAQQAWRKA LTGLDGPTLL VPAAEPRAVT
     RPERASTELS PELTARVEAL ARRLGATTST LVNVAWALVL GQLTGRSDVV FGATVHGRPA
     DLPGAERMIG LFINTVPVRV RVDLAEPFAA LLRRANGEQV SLLDHQHVGL TQIQRWAGTG
     ELFDTLVVFE SYPVDNAQLA STEAAAGITV DAVTGTDATH YPLTLVVVPG ERLSLGLDYR
     PGVADAATVL ARLTEVLTEV TANPGVLVGR IPLTIPGEPQ GAEVSVEPTT LPELFAAQVA
     ATPQAVAITS GGRSLTYAEF EDLVGRIAAG LDVATGSLVG VSLPRSIEMV AVLYAVHRCG
     AAYVPIDPSY PAARREFLAS DSAPAVLVTP ETLPALLAGA ERKPLVTVPD TAPAYVIYTS
     GSTGQPKGVV VGHRAVVNRL RWMAAEYGFG AGQRTLQKTP ISFDVSVWEL FLPLITGGTL
     VVADPEAHRD PARLAELIRA ERVDTVHFVP SMLRPFLAQP AVDGLPLRRV VCSGEALPGD
     LVGAVRNMLR DAQLHNLYGP TEAAVDVTYH DTSQDDPGRP VPLGRPVWNT GVQVLDPALR
     PVPRGCVGEL YLSGVQLAHG YLRRPGLTAS RFVAGPDGTR LYRTGDLGRR RPDGVLEYLG
     RTDDQVKIRG LRVELGEVAA ALAVLPGVTG AEVLADGDTG LVGYLTGDRR PAAEIRADLR
     AALPEQLVPG AFVWLDEFPL TPNGKLDRAA LPKPDHAAEV GAVEPRTETE RVLAACTAEV
     LDLARVGVLD DFFALGGDSI RSLHLVGRAR GAGLRITPRQ VFELRTVAAL AEVAEAVAQE
     QPPVDEQPLI ELDEDEFAEF SGDWSVS
//