ID W5WH62_9PSEU Unreviewed; 536 AA.
AC W5WH62;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN Name=acuH {ECO:0000313|EMBL:AHH99936.1};
GN ORFNames=KALB_6577 {ECO:0000313|EMBL:AHH99936.1};
OS Kutzneria albida DSM 43870.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Kutzneria.
OX NCBI_TaxID=1449976 {ECO:0000313|EMBL:AHH99936.1, ECO:0000313|Proteomes:UP000019225};
RN [1] {ECO:0000313|EMBL:AHH99936.1, ECO:0000313|Proteomes:UP000019225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43870 {ECO:0000313|EMBL:AHH99936.1};
RX PubMed=25301375; DOI=10.1186/1471-2164-15-885;
RA Rebets Y., Tokovenko B., Lushchyk I., Ruckert C., Zaburannyi N.,
RA Bechthold A., Kalinowski J., Luzhetskyy A.;
RT "Complete genome sequence of producer of the glycopeptide antibiotic
RT Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus
RT of Pseudonocardiaceae.";
RL BMC Genomics 15:885-885(2014).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
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DR EMBL; CP007155; AHH99936.1; -; Genomic_DNA.
DR RefSeq; WP_025359816.1; NZ_CP007155.1.
DR AlphaFoldDB; W5WH62; -.
DR STRING; 1449976.KALB_6577; -.
DR KEGG; kal:KALB_6577; -.
DR PATRIC; fig|1449976.3.peg.6602; -.
DR eggNOG; COG3525; Bacteria.
DR HOGENOM; CLU_007082_5_1_11; -.
DR OrthoDB; 9763537at2; -.
DR Proteomes; UP000019225; Chromosome.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06568; GH20_SpHex_like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000019225};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..536
FT /note="beta-N-acetylhexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004873105"
FT DOMAIN 40..175
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 179..498
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 343
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 536 AA; 58582 MW; EA11E539205C1F7F CRC64;
MRTFSRRLRV VWLALLLLTT LVVPASLAQA SPRDAGALGQ VVPVPASVQP DAANPYQLSP
MAAVSFDIRS PQARQIAETL AGQLRTATGY PLPVVPATQF YQPTGISLLL GGVDGKLGDE
AYQLRSSKQG VVIKANAAAG LFRGVQTLKQ LLPAKALAKT KQQGPFGVPG GTILDHPRYG
YRSAMLDVAR HFFTVPEVES YIDEIAQYKI NYLHLHLTDS QGWRIQIDGW PKLTEIGGSS
GVGGERTGFY TQADYSKIVE YAQQRFITVV PEIEGPSHSN AARSSYAGLN CDGKTPPLWL
DITESPNSVL CLTNGTAYKM MDDVIRQLAK ITPGPYINIA GDEVDKVDKT QYAEYVNKVS
AMVAKYGKKV MGWQETLSVA KPEGMTGQFW FNELNDDAVI KAAKAGAKVV MSPADHAYLD
MKYDENNPAY PVGNYWAGFV EVQDSYNWDP ETQLAGLPAN AISGVSAAMF TELVFERKDI
DQLAFPRLAA IGEIGWSPKS THDWDSFKTR LAAQGPHMDV AGIDYYRSPQ IPWPAR
//
