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Database: UniProt
Entry: W5WLX2_9CORY
LinkDB: W5WLX2_9CORY
Original site: W5WLX2_9CORY 
ID   W5WLX2_9CORY            Unreviewed;       580 AA.
AC   W5WLX2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   05-JUL-2017, entry version 25.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=CFAL_00005 {ECO:0000313|EMBL:AHI02199.1};
OS   Corynebacterium falsenii DSM 44353.
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=1451189 {ECO:0000313|EMBL:AHI02199.1, ECO:0000313|Proteomes:UP000019232};
RN   [1] {ECO:0000313|EMBL:AHI02199.1, ECO:0000313|Proteomes:UP000019232}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BL 8171 {ECO:0000313|EMBL:AHI02199.1};
RX   PubMed=24604654;
RA   Glaub A., Bomholt C., Gravermann K., Brinkrolf K., Albersmeier A.,
RA   Ruckert C., Tauch A.;
RT   "Complete Genome Sequence of Corynebacterium falsenii DSM 44353 To
RT   Study the Evolution of Corynebacterium Cluster 3 Species.";
RL   Genome Announc. 2:e00158-14(2014).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP007156; AHI02199.1; -; Genomic_DNA.
DR   EnsemblBacteria; AHI02199; AHI02199; CFAL_00005.
DR   KEGG; cfn:CFAL_00005; -.
DR   PATRIC; fig|1451189.3.peg.1; -.
DR   KO; K02313; -.
DR   Proteomes; UP000019232; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000019232};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019232}.
FT   DOMAIN      272    400       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      484    553       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     280    287       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   580 AA;  64477 MW;  9FB9774D7D9CD399 CRC64;
     MWNAIAADWK AAPEDSDYPH LSSRQRSLLS KFTAVGLMGS IVVFEADSGY TKQEVERKLS
     SAIKQVLKSK LGMDVTLAVS SHNNAQSPAG GHDEHDDEHH ADHHGDHADH DDHTPDNDAD
     HGEHDQHTES SDPRSPRPTG TPAHLASPSH RQPHGPSQGS GSFSQVTSGI DAATNTPDQT
     GRSDSHADRS PRTAADFSDS EMSAVHPGGA VGVGGQRPQP RPGGRQPGSP NQASELDVPL
     NKDYTFDNFV VGSSNNFAAA ACRAVAEAPA RSYNPLFIWG ESGLGKTHLL HSIGHYARQL
     YPNMRVRYIS SEELTNDFIN SIANDRREAF KRNYRNLDML IVDDIQFLQG KESTQEEFFH
     TFNALHQANK QIVLSSDRHP RQLTTLEDRL RTRFEGGLIT DIQTPDLETR IAILTKKDEA
     EGVYLPEEVK ELIASRYEKS IRELEGARIR ITAHCSINKE PITAEVAERV MRDILPEDQD
     VKIVPQHVID IVAEYFNLTE DDLLGKSRSK RIAQPRKIAM YLCRELTDLS LPKVGESFGN
     RDHTTVMHAE RGIRKEMSLD KKVLDQVQTL SQKIKVYARG
//
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