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Database: UniProt
Entry: W5XWM8_9CORY
LinkDB: W5XWM8_9CORY
Original site: W5XWM8_9CORY 
ID   W5XWM8_9CORY            Unreviewed;       615 AA.
AC   W5XWM8;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   05-JUL-2017, entry version 29.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AHI18588.1};
GN   ORFNames=CCASEI_00005 {ECO:0000313|EMBL:AHI18588.1};
OS   Corynebacterium casei LMG S-19264.
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=1285583 {ECO:0000313|EMBL:AHI18588.1, ECO:0000313|Proteomes:UP000019226};
RN   [1] {ECO:0000313|EMBL:AHI18588.1, ECO:0000313|Proteomes:UP000019226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG S-19264 {ECO:0000313|EMBL:AHI18588.1,
RC   ECO:0000313|Proteomes:UP000019226};
RA   Ruckert C., Albersmeier A., Kalinowski J.;
RT   "The complete genome sequence of Corynebacterium casei LMG S-19264
RT   (=DSM 44701).";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP004350; AHI18588.1; -; Genomic_DNA.
DR   RefSeq; WP_006822288.1; NZ_CP004350.1.
DR   EnsemblBacteria; AHI18588; AHI18588; CCASEI_00005.
DR   KEGG; ccg:CCASEI_00005; -.
DR   PATRIC; fig|1285583.3.peg.1; -.
DR   KO; K02313; -.
DR   Proteomes; UP000019226; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000019226};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019226}.
FT   DOMAIN      307    435       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      519    588       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     315    322       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   615 AA;  69706 MW;  4EA1A25C704A2E9D CRC64;
     MSDQQSSLTS TWRVIVEDLL RRSEQPNSEV PTFTPQQRIK LQLLKPIMIS DGYAFLATPD
     QNSRDIVEAE LATHIAAGLS RHMGRPCSVA ITVAPPEEIA QPQTQAPPQS SHNNSSQQVN
     QFSYEQDRPR LHQVDVTNQN FHDVQRAVYD NSAKQHQSEQ NYPVNQGHQD QHGQQNFPGQ
     QNQQNQSHPT SHTQQTHNDQ REQNSRFNDV TSYRHDMSED RPAQNWQTSH SPANLDELAD
     VYQSQQTSQP SFQAPSSARI PRERPAHDPN REQSLNPKHT FDNFVIGSSN RFANGAAVAV
     AENPARAYNP LFIWGGSGLG KTHLLHAAGN YAQLLHKGLR VKYVSSEEFT NDYINSLRDD
     RQESFKRRYR NLDILMVDDI QFLEGKESTQ EEFFHTFNAL HQANKQIILS SDRPPKQLNT
     LEDRLRTRFE GGLITDIQPP DLETRIAILM KKASADGTTV DRGVLELIAS RFETSIRELE
     GALIRVSAYS SLVNEPINIE MAEIALRDLA PDSAAEQITP NTIIEVTAEF FDIDVTTLTG
     SGKKRDIAHA RQLAMYLCRE LTDLSLPKLG EQFGGKDHTT VMYAERKIKR EMTEKRETYD
     EIQALTQRIK ARGRA
//
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