ID   W5ZY55_9SALA            Unreviewed;       122 AA.
AC   W5ZY55;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|RuleBase:RU364086};
DE            Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE   Flags: Fragment;
GN   Name=BDNF {ECO:0000313|EMBL:AHI47375.1};
OS   Salamandra corsica (Corsican fire salamander).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Salamandrinae;
OC   Salamandra.
OX   NCBI_TaxID=180811 {ECO:0000313|EMBL:AHI47375.1};
RN   [1] {ECO:0000313|EMBL:AHI47375.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SA 52 {ECO:0000313|EMBL:AHI47375.1}, and SA 56
RC   {ECO:0000313|EMBL:AHI47376.1};
RX   PubMed=24412216; DOI=10.1016/j.ympev.2013.12.009;
RA   Vences M., Sanchez E., Hauswaldt J.S., Eikelmann D., Rodriguez A.,
RA   Carranza S., Donaire D., Gehara M., Helfer V., Lotters S., Werner P.,
RA   Schulz S., Steinfartz S.;
RT   "Nuclear and mitochondrial multilocus phylogeny and survey of alkaloid
RT   content in true salamanders of the genus Salamandra (Salamandridae).";
RL   Mol. Phylogenet. Evol. 73:208-216(2014).
CC   -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC       located either in the central nervous system or directly connected to
CC       it. {ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KF645882; AHI47375.1; -; Genomic_DNA.
DR   EMBL; KF645883; AHI47376.1; -; Genomic_DNA.
DR   AlphaFoldDB; W5ZY55; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|RuleBase:RU364086}.
FT   DOMAIN          57..122
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AHI47375.1"
FT   NON_TER         122
FT                   /evidence="ECO:0000313|EMBL:AHI47375.1"
SQ   SEQUENCE   122 AA;  13862 MW;  21345328C4A76B31 CRC64;
     SMRPSEDNKD ADMYTSRVML SSQVPLEPPL LFLLEEYKNY LDAANMSMRV RRHSDPARRG
     ELSVCDSISE WVTASDKKTA VDMSGQTVTV LEKVPVPKGQ LKQYFYETKC NPMGYMKEGC
     RG
//