ID W6HXE2_9HIV1 Unreviewed; 766 AA.
AC W6HXE2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 08-NOV-2023, entry version 42.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AHJ58923.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AHJ58923.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AHJ58923.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CAP256.6mo.2 {ECO:0000313|EMBL:AHJ58923.1};
RX PubMed=24590074; DOI=10.1038/nature13036;
RG NISC Comparative Sequencing Program;
RA Doria-Rose N.A., Schramm C.A., Gorman J., Moore P.L., Bhiman J.N.,
RA Dekosky B.J., Ernandes M.J., Georgiev I.S., Kim H.J., Pancera M.,
RA Staupe R.P., Altae-Tran H.R., Bailer R.T., Crooks E.T., Cupo A., Druz A.,
RA Garrett N.J., Hoi K.H., Kong R., Louder M.K., Longo N.S., McKee K.,
RA Nonyane M., O'Dell S., Roark R.S., Rudicell R.S., Schmidt S.D.,
RA Sheward D.J., Soto C., Wibmer C.K., Yang Y., Zhang Z., Mullikin J.C.,
RA Binley J.M., Sanders R.W., Wilson I.A., Moore J.P., Ward A.B., Georgiou G.,
RA Williamson C., Abdool Karim S.S., Morris L., Kwong P.D., Shapiro L.,
RA Mascola J.R.;
RT "Developmental pathway for potent V1V2-directed HIV-neutralizing
RT antibodies.";
RL Nature 509:55-62(2014).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KF996608; AHJ58923.1; -; Genomic_RNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 2.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AHJ58923.1};
KW Virion {ECO:0000256|ARBA:ARBA00022844}.
FT TRANSMEM 490..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 657..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..119
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 114..489
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 509..700
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AHJ58923.1"
FT NON_TER 766
FT /evidence="ECO:0000313|EMBL:AHJ58923.1"
SQ SEQUENCE 766 AA; 86728 MW; 5CA1417FFE3697B1 CRC64;
MLMICNGLWV TVYYGVPVWK EAKTTLFCAS DAKSYEKEVH NVWATHACVP TDPNPQELVL
ENVTENFNMW KNDMVDQMHE DIISLWDQSL KPCVKLTPLC VTLNCTTAKG INSTDNANAT
KKPNEEIKNC SFNTITEVRD KQKKEYALFY RLDLVSLNEG DSEGNSSRSG NFSTYRLINC
NTSVITQACP KVTFDPIPIH YCAPAGYAIL KCNNKTFNGT GPCNNVSTVQ CTHGIKPVVS
TQLLLNGSLA EEEIIIRSEN LTDNVKTIIV HLNEPVEINC TRPNNNTRKS IRIGPGQTFY
ATGDIIGDIR QAHCNISEIK WEKTLQRVSE KLREHFNKTI IFNQSSGGDL EITTHSFNCG
GEFFYCNTSD LFFNKTFNET YSTGSNSTNS TITLPCRIKQ IINMWQEVGR AMYASPIAGE
ITCKSNITGL LLTRDGGGNN STKETFRPGG GNMRDNWRSE LYKYKVVEVK PLGIAPTEAR
RRVVQRERRA VVGLGAVFLG FLGAAGSTMG AASITLTVQA RQLLSGIVQQ QSNLLRAIEA
QQHMLQLTVW GIKQLQARVL AIERYLKDQQ LLGMWGCSGK LICTTNVYWN SSWSNKTYNE
IWDNMTWMQW DREIDNYTDT IYKLLEVSQK QQESNEKDLL ALDSWNNLWN WFDISKWLWY
IKIFIMIVGG LIGLRIIFAV LSLVNRVRQG YSPLSFQTLT PNPRELDRLG GIEEEGGEQD
RDRSIRLVSG FFSLAWDDLR SLCLFCYHRL RDFILIAGRA VELLGR
//