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Database: UniProt
Entry: W6HXE2_9HIV1
LinkDB: W6HXE2_9HIV1
Original site: W6HXE2_9HIV1 
ID   W6HXE2_9HIV1            Unreviewed;       766 AA.
AC   W6HXE2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   08-NOV-2023, entry version 42.
DE   RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE   AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE   Flags: Fragment;
GN   Name=env {ECO:0000313|EMBL:AHJ58923.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AHJ58923.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AHJ58923.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CAP256.6mo.2 {ECO:0000313|EMBL:AHJ58923.1};
RX   PubMed=24590074; DOI=10.1038/nature13036;
RG   NISC Comparative Sequencing Program;
RA   Doria-Rose N.A., Schramm C.A., Gorman J., Moore P.L., Bhiman J.N.,
RA   Dekosky B.J., Ernandes M.J., Georgiev I.S., Kim H.J., Pancera M.,
RA   Staupe R.P., Altae-Tran H.R., Bailer R.T., Crooks E.T., Cupo A., Druz A.,
RA   Garrett N.J., Hoi K.H., Kong R., Louder M.K., Longo N.S., McKee K.,
RA   Nonyane M., O'Dell S., Roark R.S., Rudicell R.S., Schmidt S.D.,
RA   Sheward D.J., Soto C., Wibmer C.K., Yang Y., Zhang Z., Mullikin J.C.,
RA   Binley J.M., Sanders R.W., Wilson I.A., Moore J.P., Ward A.B., Georgiou G.,
RA   Williamson C., Abdool Karim S.S., Morris L., Kwong P.D., Shapiro L.,
RA   Mascola J.R.;
RT   "Developmental pathway for potent V1V2-directed HIV-neutralizing
RT   antibodies.";
RL   Nature 509:55-62(2014).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC       membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC       {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC       {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC       {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC       {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004563}.
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DR   EMBL; KF996608; AHJ58923.1; -; Genomic_RNA.
DR   GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR   Gene3D; 1.10.287.210; -; 1.
DR   Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR   Gene3D; 1.20.5.490; Single helix bin; 1.
DR   InterPro; IPR036377; Gp120_core_sf.
DR   InterPro; IPR000328; GP41-like.
DR   InterPro; IPR000777; HIV1_Gp120.
DR   Pfam; PF00516; GP120; 2.
DR   Pfam; PF00517; GP41; 1.
DR   SUPFAM; SSF56502; gp120 core; 2.
DR   SUPFAM; SSF58069; Virus ectodomain; 1.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW   Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW   Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Viral envelope protein {ECO:0000313|EMBL:AHJ58923.1};
KW   Virion {ECO:0000256|ARBA:ARBA00022844}.
FT   TRANSMEM        490..514
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        657..684
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          8..119
FT                   /note="Human immunodeficiency virus 1 envelope glycoprotein
FT                   Gp120"
FT                   /evidence="ECO:0000259|Pfam:PF00516"
FT   DOMAIN          114..489
FT                   /note="Human immunodeficiency virus 1 envelope glycoprotein
FT                   Gp120"
FT                   /evidence="ECO:0000259|Pfam:PF00516"
FT   DOMAIN          509..700
FT                   /note="Retroviral envelope protein GP41-like"
FT                   /evidence="ECO:0000259|Pfam:PF00517"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AHJ58923.1"
FT   NON_TER         766
FT                   /evidence="ECO:0000313|EMBL:AHJ58923.1"
SQ   SEQUENCE   766 AA;  86728 MW;  5CA1417FFE3697B1 CRC64;
     MLMICNGLWV TVYYGVPVWK EAKTTLFCAS DAKSYEKEVH NVWATHACVP TDPNPQELVL
     ENVTENFNMW KNDMVDQMHE DIISLWDQSL KPCVKLTPLC VTLNCTTAKG INSTDNANAT
     KKPNEEIKNC SFNTITEVRD KQKKEYALFY RLDLVSLNEG DSEGNSSRSG NFSTYRLINC
     NTSVITQACP KVTFDPIPIH YCAPAGYAIL KCNNKTFNGT GPCNNVSTVQ CTHGIKPVVS
     TQLLLNGSLA EEEIIIRSEN LTDNVKTIIV HLNEPVEINC TRPNNNTRKS IRIGPGQTFY
     ATGDIIGDIR QAHCNISEIK WEKTLQRVSE KLREHFNKTI IFNQSSGGDL EITTHSFNCG
     GEFFYCNTSD LFFNKTFNET YSTGSNSTNS TITLPCRIKQ IINMWQEVGR AMYASPIAGE
     ITCKSNITGL LLTRDGGGNN STKETFRPGG GNMRDNWRSE LYKYKVVEVK PLGIAPTEAR
     RRVVQRERRA VVGLGAVFLG FLGAAGSTMG AASITLTVQA RQLLSGIVQQ QSNLLRAIEA
     QQHMLQLTVW GIKQLQARVL AIERYLKDQQ LLGMWGCSGK LICTTNVYWN SSWSNKTYNE
     IWDNMTWMQW DREIDNYTDT IYKLLEVSQK QQESNEKDLL ALDSWNNLWN WFDISKWLWY
     IKIFIMIVGG LIGLRIIFAV LSLVNRVRQG YSPLSFQTLT PNPRELDRLG GIEEEGGEQD
     RDRSIRLVSG FFSLAWDDLR SLCLFCYHRL RDFILIAGRA VELLGR
//
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