ID   W6HZN9_HBV              Unreviewed;       664 AA.
AC   W6HZN9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE   Flags: Fragment;
GN   Name=P {ECO:0000313|EMBL:AHJ58597.1};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:AHJ58597.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:AHJ58597.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A398.5 {ECO:0000313|EMBL:AHJ58597.1};
RX   PubMed=25164924; DOI=10.1002/jmv.24057;
RA   Powell E.A., Gededzha M.P., Rentz M., Rakgole N.J., Selabe S.G.,
RA   Seleise T.A., Mphahlele M.J., Blackard J.T.;
RT   "Mutations associated with occult hepatitis B in HIV-positive South
RT   Africans.";
RL   J. Med. Virol. 87:388-400(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC       {ECO:0000256|ARBA:ARBA00007994}.
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DR   EMBL; KF475996; AHJ58597.1; -; Genomic_DNA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001462; DNApol_viral_C.
DR   InterPro; IPR000201; DNApol_viral_N.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00336; DNA_pol_viral_C; 1.
DR   Pfam; PF00242; DNA_pol_viral_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          320..563
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          155..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          187..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        187..204
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AHJ58597.1"
FT   NON_TER         664
FT                   /evidence="ECO:0000313|EMBL:AHJ58597.1"
SQ   SEQUENCE   664 AA;  74810 MW;  00A727FF56EAEB59 CRC64;
     AEDLNLGNLN VSIPWTHKVG NFTGLYSSTV PIFNPEWQTP SFPKIHLQED IINRCQQFVG
     PLTVNEKRRL KLIMPARFYP THTKYLPLDK GIKPYYPDQV VNHYFQTRHY LHTLWKAGIL
     YKRETTRSAS FCGSPYSWEQ ELQHGRLVIK TSQRHGDESF CSQPSGILSR SSVGPSIRSQ
     LKQSRLGLQP HQGPLASSQP GRSGSIRARA HPSTRRYFGV EPSGSGHIDQ SVNNSSSCLH
     QSAVRKAAYS HLSTSKRQSS SGHAVEFHCL PPSSAGSQSQ GSVFSCWWLQ FRNSKPCSEY
     CLSHLVNLRE DWGPCDEHGE HHIRTPRTPA RVTGGVFLVD KNPHNTAESR LVVDFSQFSR
     GITRVSWPKF AVPNLQSLTN LLSSNLSWLS LDVSAAFYHV PLHPAAMPHL LIGSSGLSRY
     VARLSSNSRI NNNQYGTMQN LHDSCSRQLY VSLMLLYKTY GWKLHLYSHP IVLGFRKIPM
     GVGLSPFLLA QFTSAICSVV RRAFPHCLAF SYMDDVVLGA KSVQHRESLY TAVTNFLLSL
     GIHLNPNKTK RWGYSLNFMG YIIGSWGTLP QDHIVQKIKH CFRKLPVNRP IDWKVCQRIV
     GLLGFAAPFT QCGYPALMPL YACIQAKQAF TFSPTYKAFL SKQYMNLYPV ARQRPGLCQV
     FADA
//