ID W6KLJ9_9TRYP Unreviewed; 501 AA.
AC W6KLJ9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Histone acetyltransferase {ECO:0000256|RuleBase:RU361211};
DE EC=2.3.1.48 {ECO:0000256|RuleBase:RU361211};
GN ORFNames=GSEM1_T00007201001 {ECO:0000313|EMBL:CCW61913.1};
OS Phytomonas sp. EM1.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Phytomonas.
OX NCBI_TaxID=479712 {ECO:0000313|EMBL:CCW61913.1, ECO:0000313|Proteomes:UP000027080};
RN [1] {ECO:0000313|EMBL:CCW61913.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EM1 {ECO:0000313|EMBL:CCW61913.1};
RA Genoscope - CEA;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCW61913.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EM1 {ECO:0000313|EMBL:CCW61913.1};
RX PubMed=24516393; DOI=10.1371/journal.pgen.1004007;
RA Porcel B.M., Denoeud F., Opperdoes F., Noel B., Madoui M.A.,
RA Hammarton T.C., Field M.C., Da Silva C., Couloux A., Poulain J.,
RA Katinka M., Jabbari K., Aury J.M., Campbell D.A., Cintron R., Dickens N.J.,
RA Docampo R., Sturm N.R., Koumandou V.L., Fabre S., Flegontov P., Lukes J.,
RA Michaeli S., Mottram J.C., Szoor B., Zilberstein D., Bringaud F.,
RA Wincker P., Dollet M.;
RT "The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic
RT Kinetoplastids Reveals a Parasite Tailored for Plants.";
RL PLoS Genet. 10:e1004007-e1004007(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-
CC lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752,
CC Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC Evidence={ECO:0000256|RuleBase:RU361211};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU361211}.
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|RuleBase:RU361211}.
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DR EMBL; HF955066; CCW61913.1; -; Genomic_DNA.
DR AlphaFoldDB; W6KLJ9; -.
DR EnsemblProtists; CCW61913; CCW61913; GSEM1_T00007201001.
DR OrthoDB; 125244at2759; -.
DR Proteomes; UP000027080; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.40.630.30; -; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR002717; HAT_MYST-type.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF161; HISTONE ACETYLTRANSFERASE KAT5; 1.
DR Pfam; PF01853; MOZ_SAS; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|RuleBase:RU361211};
KW Reference proteome {ECO:0000313|Proteomes:UP000027080}.
FT DOMAIN 135..437
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
SQ SEQUENCE 501 AA; 58140 MW; F3B2F6128DE2634C CRC64;
MQIGQPCRLD NSHYSMVYDS ASSLPPRAIG FIIAQRPHLD NLSRILYYFR TTHIEFPDTA
NGSVKRRSRI GGQVNSHNAK EDSRFNRLHA SSQAFVSSEG YFYRFDGWYD AVFLYPIDGK
GVLENIPNDW LSSVERNTAP CEMQYLCYSF HPWFSSPFHA LQYLALPESG VCYSVSICHR
CLSPFFSEKH LTIHMEGYCE RLDPPGTLIY HDPTSGRRVW YVDGAQHLHY ARCISLLGNC
FIESKLLRND VDMYEFFIIT LPRTALPYVP GSHFENETQF KRSAVSFDKA KWSGHVVAGY
FSRLKHKPHH TLSCIVTLPM FQRMRLGSFM LDVAYALMVE RGQQCGCSQW CGCLKQDGGC
ISRPFSPHGE SLLLSYWRRS LERLSRNRKH EANPNVFSTL EELRSAMDIP IAAKDLLFLL
THDNIAFYSS SEKHWDTRSP CEFNEVVNKR TYNVSLVFDK HQIETIFEKP DQGYELGDFQ
RKWFRRNTDQ SLVYNKTLFH Y
//
