ID W6KX07_9TRYP Unreviewed; 2145 AA.
AC W6KX07;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=RNA helicase {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSEM1_T00007182001 {ECO:0000313|EMBL:CCW61896.1};
OS Phytomonas sp. EM1.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Phytomonas.
OX NCBI_TaxID=479712 {ECO:0000313|EMBL:CCW61896.1, ECO:0000313|Proteomes:UP000027080};
RN [1] {ECO:0000313|EMBL:CCW61896.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EM1 {ECO:0000313|EMBL:CCW61896.1};
RA Genoscope - CEA;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCW61896.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EM1 {ECO:0000313|EMBL:CCW61896.1};
RX PubMed=24516393; DOI=10.1371/journal.pgen.1004007;
RA Porcel B.M., Denoeud F., Opperdoes F., Noel B., Madoui M.A.,
RA Hammarton T.C., Field M.C., Da Silva C., Couloux A., Poulain J.,
RA Katinka M., Jabbari K., Aury J.M., Campbell D.A., Cintron R., Dickens N.J.,
RA Docampo R., Sturm N.R., Koumandou V.L., Fabre S., Flegontov P., Lukes J.,
RA Michaeli S., Mottram J.C., Szoor B., Zilberstein D., Bringaud F.,
RA Wincker P., Dollet M.;
RT "The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic
RT Kinetoplastids Reveals a Parasite Tailored for Plants.";
RL PLoS Genet. 10:e1004007-e1004007(2014).
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DR EMBL; HF955066; CCW61896.1; -; Genomic_DNA.
DR EnsemblProtists; CCW61896; CCW61896; GSEM1_T00007182001.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000027080; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:UniProt.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF13; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 2.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000027080}.
FT DOMAIN 444..626
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 661..862
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1310..1484
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1515..1713
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 80..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2145 AA; 243320 MW; E81FD03433504194 CRC64;
MPPERSLCAK CKSYDEGAID LDDRQWYCNS CWAAHDRAMS NQKLKKNDFK VQTNDVLKIS
NATRNTDGCK QVNSEGIGTK LTDGGDTQRT GELIGSSQHA KVDKWMGGGS PKTSEVSVNR
SGQGAMMDAV EAAWRRQHDA FHSCTPSQNA VPSVYSTLAQ DFSAEGSSPT SFVAACMQPQ
QPVRIITHSG VPLSPRGDRA GGTGQLTHPR LPKVPLDMLL STLDDIVSQV YVVFDEDLTK
ILLNGLDRVT ACETVDQREL MKMRVMNTFL ETFGDKHYDL LQCILYKPRE VFLRLLEGFC
TLGDDEKDNN SSTGGSNPIG LTVRFVKSGG KQRSQCQSVA FDSNGNIENQ RWLQHMNSRY
RALLAESELE FMFRKDFSVT GSAVPKGTTV TKQSDYVRIH IPSLNLEMLP LDKRICVATS
LPEWTHPAFF PITHLNTIQT SIFETAFHTS QNMLVCAPTG AGKTVCALLM MLRCISEHFV
NGILNRDFKI IFVAPMKALA QEMVANFSRR MAPFMIKVRE LTGDMQLTKR EIAETQVIVT
TPEKWDVITR KRSNEEFFNK VKLLIIDEIH LLNEERGPVL EAIVARTMRQ GEMDSNLRVR
LVGLSATLPN YKDVANFLHV DLKDGLKVFG PEYRPVPLEQ TFIGMQGVPS KHKERRLDEL
AYQEVLQNVM EGHQVMVFVH SRKQTVNLCR YFMEETRARG NERYFRYNTV LPTNIEKKAR
NLQGKDLYTL FESGFGAHHA GLIRFDRTTT EDLFREGYIR VLCCTSTLAW GVNLPAHTVV
IRGTQLYDPK RGGLVSISVL DVMQIFGRAG RPQFDTKGHG IIISDDKEIG YFLRLISSSL
PIESQMQSKL WDHLNAEVNA GTISSIAEAS SWLEYTYLWQ RIRVNPLIYN LKISSVRKDP
ELKGTRYEII HNVFSDLAVS GMVRYNPEIG SVESTDLGRM ASHYYLTYTT VNVFNKMMRR
RDGTWEDSLD MGTAMNILSC ASEFSAQHVR QEELDQLQKL HLQLPRQVRE YRIAGESTDE
TSVQWKVTTL LKAYISRLHI EDHSLSADVN YIAQNAPRIS RALFEIELER GHPLTTYIFL
TLYKCLVHRC WDFDHPLLQF TSWINRVNIP DAVWGYLSSR NPSISTLQEL TPKEIGDMVH
NMRCGRDIAL LVSKFPTLQL HIDVQPITKS ILRVKATIQP NFEWGRDISG NSEVFWLLVE
DQDNNFIFHH ESVVITRKEV ESGTPHVVNL TIPIVPQYDM YSVRLYSDRW MGCQEDYTFS
IGHLHLPEDT QMTTKLLPLA PLRLSVLPEK YQKLFESHHQ FNAMQTQVFH VMYHTDENVF
LGAPTGSGKT ISAELAILRV FDNFRSGKVV YIAPLKALVK ERLRDWQRRM RLIGRSVVEL
SGDATPDIIA LAKADILCTT PEKWDGISRN WQVRSYVTSV KLVVFDEIHM LGTDRGPILE
VIVSRMRHIG WSLNAPIRLV GLSTAVSNPS DLSSWLGVVK KWAVFNFDPS VRPVPMLVHI
AGYHGKHYSP RMATMNKPTY NAICEKSPTQ PVIVFVSSRR QTRRTALALI GFLLAENNTA
KWIHMEVDEI EKMIAKLTDP YLKHCLQFGV GIHHAGLLES DRSIVEEAFL STKIQVLVAT
STLAWGVNFP AHMVIVKGTE YYNAKTHSYV DFPITDVLQM IGRAGRPQYD TEGVAQVLCH
EPKKGFYRKF LYDPFPVESA LHTQLHVHIN AEIVSGIIAT RQDAMNYLTW TYLFRRITRN
PSYYGLEDGS PEAVTTFLSD LVKATLEELE EYGCIEFGDQ TDENANLNAL QHTVLGKLCA
YYYISHRTAG MFNRRIQPSI SCVEALRILC DAEEFNELPV RHNEDKLNME LASGLPFPVS
DEEADSPNLK AFLLFQAHFE RAELPVTDYV TDQKSATDNA VRVIQAMVDV AANNGHLYAS
LRCMTLMQCI VQGMWWNGPT LLQIPNVTLE MLPAIQSECG ISQISELANS PLETIQRFEK
VLQRPVFGLT PDQVNEAMEG IRGLPLVQVD VFVRYLQPET TGAQEFRTND GNDIPVFEVS
VHLERLSHPR NYVVAPRFSK NKDEQYWVCL GHEATGELVA LKRVNRLNHR SVTKLRVEWD
EDWSSAPVQR LLRGNTRGGT KLSVYVVCDS FVGMDQQYTF ELSRP
//
