ID W6LAQ7_9TRYP Unreviewed; 944 AA.
AC W6LAQ7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273};
DE EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273};
GN ORFNames=GSHART1_T00007822001 {ECO:0000313|EMBL:CCW70272.1};
OS Phytomonas sp. Hart1.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Phytomonas.
OX NCBI_TaxID=223615 {ECO:0000313|EMBL:CCW70272.1, ECO:0000313|Proteomes:UP000053358};
RN [1] {ECO:0000313|EMBL:CCW70272.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hart1 {ECO:0000313|EMBL:CCW70272.1};
RA Genoscope - CEA;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCW70272.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hart1 {ECO:0000313|EMBL:CCW70272.1};
RX PubMed=24516393; DOI=10.1371/journal.pgen.1004007;
RA Porcel B.M., Denoeud F., Opperdoes F., Noel B., Madoui M.A.,
RA Hammarton T.C., Field M.C., Da Silva C., Couloux A., Poulain J.,
RA Katinka M., Jabbari K., Aury J.M., Campbell D.A., Cintron R., Dickens N.J.,
RA Docampo R., Sturm N.R., Koumandou V.L., Fabre S., Flegontov P., Lukes J.,
RA Michaeli S., Mottram J.C., Szoor B., Zilberstein D., Bringaud F.,
RA Wincker P., Dollet M.;
RT "The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic
RT Kinetoplastids Reveals a Parasite Tailored for Plants.";
RL PLoS Genet. 10:e1004007-e1004007(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|RuleBase:RU004273};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the PPP phosphatase family.
CC {ECO:0000256|RuleBase:RU004273}.
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DR EMBL; HF955206; CCW70272.1; -; Genomic_DNA.
DR AlphaFoldDB; W6LAQ7; -.
DR EnsemblProtists; CCW70272; CCW70272; GSHART1_T00007822001.
DR OrthoDB; 141471at2759; -.
DR Proteomes; UP000053358; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45668; SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED; 1.
DR PANTHER; PTHR45668:SF13; SERINE_THREONINE-PROTEIN PHOSPHATASE; 1.
DR Pfam; PF00149; Metallophos; 1.
DR PRINTS; PR00114; STPHPHTASE.
DR SMART; SM00156; PP2Ac; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU004273};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053358}.
FT DOMAIN 405..410
FT /note="Serine/threonine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS00125"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 944 AA; 109730 MW; 762DDC4F71FAF88D CRC64;
MGCNSSKKID ESLKNRPPKG RSRKHRKGRD EEAANGTESD LTPPDSQRWD PHRVAEDRRR
LPNCHFCHLP ILDKDYNAHT VMCDEREVTC WNLWCQKIVK QRDLTTHLEE CGRWQKAICP
KCGLEVLVSE MQNHRDGCNP KPCPSCGEVC IIRIHKWCPK TYVDNLELKN GPFAKQSLLA
KYCAEKKKKT HLERQEFNIA RIQLLWHWIK CKYLVEETIF RCVYKEMDFK KEGFAIFKAH
DKVNDSHVLA PRRSRSVIQA PVVAPASFSH YFPVNSNTPI TLYHVQRMMQ DMRRHILLPY
PAAWRIFTNA MNHLNTLPNV VRMSPSVGAR DVNGRFSQGC KVVVVGDIHG QLTDLLHILQ
ECGMPGENNY YIFNGDFVDR GQYGVEVLII LFSLMLACPK YVTLNRGNHE CDYMNDEYGF
DVEVSTKYDR NIFRLIQRCF CALPLATIIG NKIFVVHGGL PRRMGVTIDD LSRIQRFRQV
PMPNRSQPEE DEIFQDLLWS DPVEDITDWR ESPRGAGVEF GVKVTNSFLE TNNLKLVVRS
HEECVSGYQE LHDKKLFTVF SASNYDGPDT NYGAICSFIA DSIDPSFQIY QVYEEDLEEQ
SLNITDSFAI NTPIAARLAS FTVNNPGSFR QILRRGTKYD ILRELRERIY QRRHRLMAYF
SKLDRTNKGS VWIIEWAETM RNVLNLDLPW YFLRGYLVSL DKDARTQYSP FLKDYHNILQ
YLWVNSWAQA TCAQLQQQQR SNHRSRLVTI AFNKDVVTYN DYCSVLRAID YTISEFQLFQ
LFQFFDTEGQ GHLCGPAFLK QMQLIANRKL DPLRWDVDAM EQLQNTLIQG RSQLSSLFKV
TSRDRVLCKE KFMDGMAQLG RGMRKQLTHP QKEAIYDFMR NLVPEHEEVT FSAFLTIVCV
FNIVLPPSSS SYPNTPDMDL LQRLFSNENI YVSPYPMSPK MVKH
//
