ID   W6M386_9GAMM            Unreviewed;      1416 AA.
AC   W6M386;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   ORFNames=BN873_230067 {ECO:0000313|EMBL:CDI02052.1};
OS   Candidatus Competibacter denitrificans Run_A_D11.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria;
OC   Candidatus Competibacteraceae; Competibacter.
OX   NCBI_TaxID=1400863 {ECO:0000313|EMBL:CDI02052.1, ECO:0000313|Proteomes:UP000035760};
RN   [1] {ECO:0000313|EMBL:CDI02052.1, ECO:0000313|Proteomes:UP000035760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Run_A_D11 {ECO:0000313|EMBL:CDI02052.1,
RC   ECO:0000313|Proteomes:UP000035760};
RA   McIlroy S.;
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDI02052.1, ECO:0000313|Proteomes:UP000035760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Run_A_D11 {ECO:0000313|EMBL:CDI02052.1,
RC   ECO:0000313|Proteomes:UP000035760};
RA   McIlroy S.J., Albertsen M., Andresen E.K., Saunders A.M., Kristiansen R.,
RA   Stokholm-Bjerregaard M., Nielsen K.L., Nielsen P.H.;
RT   "Candidatus Competibacter-lineage genomes retrieved from metagenomes reveal
RT   functional metabolic diversity.";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDI02052.1}.
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DR   EMBL; CBTJ020000029; CDI02052.1; -; Genomic_DNA.
DR   RefSeq; WP_048671760.1; NZ_CBTJ020000029.1.
DR   STRING; 1400863.BN873_230067; -.
DR   OrthoDB; 5618688at2; -.
DR   Proteomes; UP000035760; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR024983; CHAT_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR   PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR   Pfam; PF12770; CHAT; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   Pfam; PF13424; TPR_12; 1.
DR   SMART; SM00255; TIR; 1.
DR   SMART; SM00028; TPR; 5.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000035760}.
FT   DOMAIN          3..138
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   1416 AA;  158143 MW;  3D30354B1FB20680 CRC64;
     MMAAPQIFIC HAQPDAAFAR DLGLALETFR LPVWNDSRNL RGGNRLAPEV RWAIEQARQV
     IVVLGLNTGD PTWLRREIEI AQEVERRRAD RYRVIPLLLP GVDEAMLPQW FTPVPRTAPL
     QLPSDGLGPI LPTLLTVLGE TSPAGSATDR HAQPPTELAL SFSQSTSSTA SWQWVARLNS
     QPDEDPPLTL SCPLPIAPSR ELQHWYLQTY PCWPTDVLRD LADHVAIQLA QWGRSLYQIV
     LNAPESQALT TVWRQLLSSQ EGCLVIKADG ADSATVDLLE LPWELLHDAN DFLIRAKKPV
     QVIRRLPGGS GAFLPVPPPL RILAASPHPD TEPTGHSDYR RGTLPLMAAL ASLGGLVEPR
     ILTSPTLAAL EKQLNDAWVT GRPFSILHLD AYLREDLATQ EVQCAFETGY DPPAPLCREA
     HFVPVKELIS LLSSYRIRLV VLYGGNTNAA DSATFRLTSL LLASGIAAAI TVHPAVPTET
     QKRFWKGFYE ELLRGARISQ ALFAGQNYLV GDTYRAAGMS GGIHLQDWFC FKLYVGEQDP
     RLCLRPPLDL RRRLLELTWP EPSAHLPTPP PTGFVGRTRD LLRLERLLKE QSTLFLRGAG
     GSGKTATASA LAHWLVRSGR FHQIAYLNRD DAREPSYLLE TLGRQLLPQN KHWSVETYPT
     FWRALSHLQK TLEKKSTLIV LDQIERWPSE HDKLFDQLWQ DLLNACPGLR LLGLGRLGPP
     PFAQPWKELK LSPLDENDAI CLIGRTLIGA RELPPASDAK DGFQPLRQLV KLAGGHPVAL
     QRISHEIAIH GAKATLALLH TLRAEILYRH PDDPQWPLFL GLELTLRQLP AEDRERSAII
     AFFKGGMNRI ALGKALVLDT QDLDAFQKRL SALELIEDQG YGHWRFDPAL SHYLANQLSP
     SHRLIWQDRW RNGMEELIDV LYQQYFKDNA RTTRLLRLEL PNLLTFLRDH QQHFSAERTA
     RLASRLEQLL VSLGIPNALG EAMAARERAG HALSGWSRLR FETERLRVER LRDNGALEEA
     FQAARQLLRQ CQEAGPDSYP GAGYDLAQAF FQLGKLLKLT GAAESAVREF SVARQQFQSL
     AETGNSNAGR MAAVVDAEIG DCLAYLQRLQ EAATAYEAAL TQSGPNAPKG LIANNKMQLG
     LVRQRQGHYS EAVDLYDSAR QIFEALGEPE GTARAWRQIA LSHKLSADMK PALHACQQAL
     YLYEQQRDRN SITETLGELG HLHQISNQLE EAALAYRRLS ELCTQLGDSL GEEASRNKLA
     NVLIQLHRHD EARQELYRAS ECNLPDSYTA RNWAIRRGLH DLGQTAQNQD VADRARRQAM
     QKYLAYRRAG GENDNPGARL CAQVHQAIRT GETSSLAAKL EQIAASPNVP AGGKLLIDKL
     KNILMGSYEP TLATDPNLHY QYAVELQLLL EALTQR
//