ID   W6ML79_9ASCO            Unreviewed;       765 AA.
AC   W6ML79;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   13-SEP-2023, entry version 46.
DE   RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=KUCA_T00002832001 {ECO:0000313|EMBL:CDK26858.1};
OS   Kuraishia capsulata CBS 1993.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetales incertae sedis; Kuraishia.
OX   NCBI_TaxID=1382522 {ECO:0000313|EMBL:CDK26858.1};
RN   [1] {ECO:0000313|EMBL:CDK26858.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CBS 1993 {ECO:0000313|EMBL:CDK26858.1};
RA   Genoscope - CEA;
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDK26858.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CBS 1993 {ECO:0000313|EMBL:CDK26858.1};
RA   Morales L., Noel B., Porcel B., Marcet-Houben M., Hullo M-F., Sacerdot C.,
RA   Tekaia F., Leh-Louis V., Despons L., Khanna V., Aury J-M., Barbe V.,
RA   Couloux A., Labadie K., Pelletier E., Souciet J-L., Boekhout T.,
RA   Gabaldon T., Wincker P., Dujon B.;
RT   "Complete DNA sequence of /Kuraishia capsulata/ illustrates novel genomic
RT   features among budding yeasts (/Saccharomycotina/).";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HG793127; CDK26858.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6ML79; -.
DR   STRING; 1382522.W6ML79; -.
DR   HOGENOM; CLU_007879_0_0_1; -.
DR   OrthoDB; 23973at2759; -.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd05992; PB1; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR010481; Cdc24/Scd1_N.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR000270; PB1_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR47339; CELL DIVISION CONTROL PROTEIN 24; 1.
DR   PANTHER; PTHR47339:SF1; CELL DIVISION CONTROL PROTEIN 24; 1.
DR   Pfam; PF06395; CDC24; 1.
DR   Pfam; PF00564; PB1; 1.
DR   Pfam; PF15411; PH_10; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00666; PB1; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS51745; PB1; 1.
PE   4: Predicted;
FT   DOMAIN          235..410
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          674..765
FT                   /note="PB1"
FT                   /evidence="ECO:0000259|PROSITE:PS51745"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          580..622
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        608..622
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   765 AA;  86033 MW;  030EA278E98C921A CRC64;
     MSHMPGLKSA TSFSSSSSLA RTPSGPMVAA GLIMNKRADV NESLYYICQR LIAKLEKVPG
     MKAYLNLAFS SAEECSEQQA MLLSQRPASS SSHHNSTSSL DSEISVRSKW DRTMLTFSAG
     MLPAQINYDP VTPVWRLFQQ GVPLCLIFNS LKPEHSIPLV SSDDLKVCKM NVYRFLSCCK
     QYLDIRDEDL FPITSVFADD TNNLLKVIKV VNSVLDLDPR FTAPEIEETY KVTDARSKVV
     KELVESERKF VQDLETLLRY RDDVMKRELI SSEDLGILFP NLPEIVDFQR RFLVGLECNA
     SVPEKYQRIG SVFLHAGVQG FKIYDPWSLL QTQAIDVIAR EAGNLKRSSS LIDASYELQS
     FLIKPVQRLC KYPLLLQQLL KLTDSSWPNY NELEASLESS KEVAHNVNEA QRKSENVQLV
     KDLQERVVDW RGHGLLNVGE LLFSNTVVVK DLLSDGPSSE KEVHCYMFEK IIYFFKEMAP
     KNKILSARKK SSASLTSSSG SLNGSQSNLY LNGRVFISNI NVITSNDAGS FGGPGRYLTI
     RWKGTKERGG CVIKFRSEEQ LVRWEAALKR LTKDQELDMP KVRNRDNSGS SEGEYLPKFP
     PVVDSPMGSA RSSASSIQDS FKMPHVRQKS EVSLLSYGAP GPYSDEKKNR SVSSPATLVG
     SLAHHVASVE LREQVNIKLT YKNENVHLSV QPHVVFADLL TTFLNKLRLT IGDDLKADDT
     LKLKYRDEDD DLIQFRSDDD WTVARDMLNQ IADEESRILN IVVTV
//