ID W6QLJ8_PENRF Unreviewed; 333 AA.
AC W6QLJ8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Dihydrodipicolinate synthetase-like {ECO:0000313|EMBL:CDM36851.1};
GN ORFNames=PROQFM164_S05g000684 {ECO:0000313|EMBL:CDM36851.1};
OS Penicillium roqueforti (strain FM164).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1365484 {ECO:0000313|EMBL:CDM36851.1};
RN [1] {ECO:0000313|EMBL:CDM36851.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FM164 {ECO:0000313|EMBL:CDM36851.1};
RX PubMed=24407037; DOI=10.1038/ncomms3876;
RA Cheeseman K., Ropars J., Renault P., Dupont J., Gouzy J., Branca A.,
RA Abraham A.L., Ceppi M., Conseiller E., Debuchy R., Malagnac F., Goarin A.,
RA Silar P., Lacoste S., Sallet E., Bensimon A., Giraud T., Brygoo Y.;
RT "Multiple recent horizontal transfers of a large genomic region in cheese
RT making fungi.";
RL Nat. Commun. 5:2876-2876(2014).
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
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DR EMBL; HG792019; CDM36851.1; -; Genomic_DNA.
DR AlphaFoldDB; W6QLJ8; -.
DR STRING; 1365484.W6QLJ8; -.
DR OMA; MVPVCAG; -.
DR OrthoDB; 1780992at2759; -.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128:SF72; 4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|PIRNR:PIRNR001365}.
FT ACT_SITE 147
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 177
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 230
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 333 AA; 35925 MW; 634343233423EA26 CRC64;
MAYSTRPLRP GVYVPLPTFF DEHQEIDYDS YRRHLLAMVT RGMVPVCAGS LGEAVHLDFD
ERVSLIRFIR ETLDGAGLQS TPIVAGVGGL STRETISLSK AAADAGADAG MVILPAYYAA
SLNTDMDQVI QYYVDICEAS PIPLLLYNFP SNAGGQDMSS EVISAIMKKT SNLCGVKLTC
GGSMGKLIRL QALISEDTTI NETRKFPFLL LDGLIADLTP WMQCAGHGTV SGIPNFVPVA
SMRLWSLLNL PSPTETERNE ARNIQAILAR ADAAAVPGGI RAMKYALNKM HGYGIAPRRP
LLPLGEAEGG EFMNALGEAM RLESELREAT STP
//
