ID W6S0U4_9CLOT Unreviewed; 421 AA.
AC W6S0U4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=O-acetylhomoserine (Thiol)-lyase {ECO:0000313|EMBL:CDM67882.1};
DE EC=2.5.1.49 {ECO:0000313|EMBL:CDM67882.1};
GN ORFNames=CM240_0717 {ECO:0000313|EMBL:CDM67882.1};
OS Clostridium bornimense.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1216932 {ECO:0000313|EMBL:CDM67882.1, ECO:0000313|Proteomes:UP000019426};
RN [1] {ECO:0000313|EMBL:CDM67882.1, ECO:0000313|Proteomes:UP000019426}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M2/40 {ECO:0000313|Proteomes:UP000019426};
RA Wibberg D., Puehler A., Schlueter A.;
RT "Complete genome sequence of Clostridum sp. M2/40.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HG917868; CDM67882.1; -; Genomic_DNA.
DR RefSeq; WP_044036520.1; NZ_HG917868.1.
DR AlphaFoldDB; W6S0U4; -.
DR STRING; 1216932.CM240_0717; -.
DR KEGG; clt:CM240_0717; -.
DR PATRIC; fig|1216932.3.peg.703; -.
DR eggNOG; COG2873; Bacteria.
DR HOGENOM; CLU_018986_4_2_9; -.
DR OrthoDB; 9780685at2; -.
DR Proteomes; UP000019426; Chromosome 1.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR PANTHER; PTHR43797:SF3; O-ACETYLHOMOSERINE SULFHYDRYLASE; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:CDM67882.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000019426};
KW Transferase {ECO:0000313|EMBL:CDM67882.1}.
FT MOD_RES 204
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 421 AA; 46502 MW; B71BCAA20CD6D067 CRC64;
MNIETKCLHE GYKPRNGEPL SLPIYQSTTY NYESTEHIGK LFDLTVEGHM YSRISNPTVA
AVEEKIAALE GGVGALCTTS GQAAILISLL NILSAGDHFI SASKIYGGTI NLFSVTLKKF
GIECTFVDPD LPEEELQKYF KKNTKAVYGE TLANPALSVL DIEKFVKVAH ENNVPFIIDN
TFATPILCRP IEYGADIVIH STTKYMDGQA VQVGGVIVDS GNFNWCNGKY KEFTEPDESY
HGVIYTKDFG KAAFITKARV QMMRDLGAYP SANSAFLLNL GLQTLPVRIE RHCENAKKVA
EYLNNSEKVE FVNYPALPNN KYYELYKKYL PKGCSGVISF SIKGTRETAV KFMDSLKLAS
NAVHVADIHT LILHPASSTH RQLNDEQLVA AGITPGLIRL SVGLENVEDI IADLEQGLER
I
//
