ID W6T995_9LACO Unreviewed; 937 AA.
AC W6T995;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=DNA translocase FtsK {ECO:0000256|ARBA:ARBA00020887};
GN ORFNames=LFAB_06500 {ECO:0000313|EMBL:ETY74448.1};
OS Lactiplantibacillus fabifermentans T30PCM01.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactiplantibacillus.
OX NCBI_TaxID=1400520 {ECO:0000313|EMBL:ETY74448.1, ECO:0000313|Proteomes:UP000019247};
RN [1] {ECO:0000313|EMBL:ETY74448.1, ECO:0000313|Proteomes:UP000019247}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30PCM01 {ECO:0000313|EMBL:ETY74448.1,
RC ECO:0000313|Proteomes:UP000019247};
RX PubMed=24558238;
RA Treu L., Vendramin V., Bovo B., Giacomini A., Corich V., Campanaro S.;
RT "Genome Sequence of Lactobacillus fabifermentans Strain T30PCM01, Isolated
RT from Fermenting Grape Marc.";
RL Genome Announc. 2:e00060-e00014(2014).
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA.
CC {ECO:0000256|ARBA:ARBA00025923}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETY74448.1}.
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DR EMBL; AWWK01000032; ETY74448.1; -; Genomic_DNA.
DR RefSeq; WP_024623785.1; NZ_KK036485.1.
DR AlphaFoldDB; W6T995; -.
DR STRING; 1400520.LFAB_06500; -.
DR PATRIC; fig|1400520.3.peg.1266; -.
DR eggNOG; COG1674; Bacteria.
DR HOGENOM; CLU_001981_12_4_9; -.
DR OrthoDB; 9807790at2; -.
DR Proteomes; UP000019247; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF42; DNA TRANSLOCASE SFTA; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000313|EMBL:ETY74448.1};
KW Cell division {ECO:0000313|EMBL:ETY74448.1};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}.
FT DOMAIN 603..795
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 183..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 620..627
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 937 AA; 98607 MW; CCF8CE4ED59FA359 CRC64;
MNHYDGPAFF RKYPIVKPNK PVSAASQSTS AASAATSQAQ PVVSQAVRPV SSAAPVKPQT
TPTSATSQAE LFNSGTHGSF HPSQIPAQIS PALATGGVIV DSDQTNYLEV EASLHKAPDS
FFLMAKVTDD HLELVDLAHP ELSQAATAAE PTVTFEPQAT ATTAAPTEVI APQTTVQATV
ASTTAPTEVL QPQSAVASTT APTEVIQPQS SAASTAAVTS TTAPTEVLQP QSAAVTTPAS
ASASRARSIP TATETTQAVA TEVFTPDSVG AKAAQQSMAA LQHPTTVFEP DEAAVAALQT
SLAAPSSMPA QVASLAAMAV ADAEAESTAP STAPTHGLGL SLGDIMTEEH NAQSDLALFK
DAPKAEEGSV TTAATVENTT TPTTTTVSPT ATTSAQAEEP YQPVGAQPRV QPTPAPRAIT
PARPVSPTTT APMPVAATVA PTSAPVEAPH NPDSAAPVLD DKALAAYHLP PLDLLKAPVV
PDESEMDDWI ESKASALDES LDAFGVDANV VDWTIGPTVT QFQVKLARGV KVSKITNLND
DLKLALAAKD IRIEAPIPGR NTVGIEIPNK KSRPVMLSEV LNSEKFKTSK SPLTVALGVD
LFGQPQVTDL RKMPHGLIAG ATGSGKSVFI NSILVSLLYK ANPQEVKLLL IDPKAVEMAP
YDKVPHLIAP VISEPKAASA ALKWVVDEMD NRYDKLAAGG ARNIEQFNQL AEDHHEPSLK
MPYIVIVIDE LADLMMVASS EVQDYIARIT QKARAAGIHL LVATQRPSVD VVTGLIKNNI
PTRVAFMVAS QIDSRTILDA SGAERLLGRG DMLYLGNGQS TPIRLQGTYV DSEIDDIAQY
VRDQAAPHYE FQPDSLMKHE EAAKNQDELM PEVLAYLAEE DTVSTSKLQR KFSVGYNRAA
NIIDDLEGRG YVSPAKGSKP RDIYFSADDL TKLQANS
//
