ID W6TCM8_9LACO Unreviewed; 309 AA.
AC W6TCM8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Homocysteine methyltransferase {ECO:0000313|EMBL:ETY74665.1};
GN ORFNames=LFAB_06010 {ECO:0000313|EMBL:ETY74665.1};
OS Lactiplantibacillus fabifermentans T30PCM01.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactiplantibacillus.
OX NCBI_TaxID=1400520 {ECO:0000313|EMBL:ETY74665.1, ECO:0000313|Proteomes:UP000019247};
RN [1] {ECO:0000313|EMBL:ETY74665.1, ECO:0000313|Proteomes:UP000019247}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30PCM01 {ECO:0000313|EMBL:ETY74665.1,
RC ECO:0000313|Proteomes:UP000019247};
RX PubMed=24558238;
RA Treu L., Vendramin V., Bovo B., Giacomini A., Corich V., Campanaro S.;
RT "Genome Sequence of Lactobacillus fabifermentans Strain T30PCM01, Isolated
RT from Fermenting Grape Marc.";
RL Genome Announc. 2:e00060-e00014(2014).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU00333};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETY74665.1}.
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DR EMBL; AWWK01000028; ETY74665.1; -; Genomic_DNA.
DR RefSeq; WP_024623868.1; NZ_KK036481.1.
DR AlphaFoldDB; W6TCM8; -.
DR STRING; 1400520.LFAB_06010; -.
DR PATRIC; fig|1400520.3.peg.1171; -.
DR eggNOG; COG2040; Bacteria.
DR HOGENOM; CLU_004914_3_2_9; -.
DR OrthoDB; 9803687at2; -.
DR Proteomes; UP000019247; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.330; Homocysteine-binding-like domain; 1.
DR InterPro; IPR003726; HCY_dom.
DR InterPro; IPR036589; HCY_dom_sf.
DR PANTHER; PTHR46015:SF1; ZGC:171603 PROTEIN; 1.
DR PANTHER; PTHR46015; ZGC:172121; 1.
DR Pfam; PF02574; S-methyl_trans; 1.
DR SUPFAM; SSF82282; Homocysteine S-methyltransferase; 1.
DR PROSITE; PS50970; HCY; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00333};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU00333};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00333}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00333}.
FT DOMAIN 3..307
FT /note="Hcy-binding"
FT /evidence="ECO:0000259|PROSITE:PS50970"
FT BINDING 227
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
FT BINDING 292
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
FT BINDING 293
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
SQ SEQUENCE 309 AA; 33307 MW; 487C0F8CB2C40D73 CRC64;
MQVLSLNDRL KQGPVVLDGA MATELEKRGV ATDSALWSAT AMLDHPQAIT AVHQSYFAAG
AQIAITNTYQ ANVAAFVQAG VSAEKARPLI QQAVQIANTA RDNYAQTHPD FQGYVAGSIG
SYGAYLADGS EYTGKYHLDE VAYQAFHRER LQLITAVGVD VLALETMPNF AEVQALVHLI
TAEFPAQPYW VSFSIADAQH LWDGTDLATA AKWVAAQPNV VAVGVNCTRL ENIEPALQTL
RDAVEIPLIV YPNSGDEYDA VTKTWQTTDA SHTFDQFVPK WLAAGANIIG GCCRTTPADI
QTIAQLING
//
