ID W6TD61_HOLOB Unreviewed; 720 AA.
AC W6TD61;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=DNA translocase FtsK {ECO:0000256|ARBA:ARBA00020887};
GN ORFNames=P618_200976 {ECO:0000313|EMBL:ETZ06863.1};
OS Holospora obtusa F1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Holosporales; Holosporaceae;
OC Holospora.
OX NCBI_TaxID=1399147 {ECO:0000313|EMBL:ETZ06863.1, ECO:0000313|Proteomes:UP000019112};
RN [1] {ECO:0000313|EMBL:ETZ06863.1, ECO:0000313|Proteomes:UP000019112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F1 {ECO:0000313|EMBL:ETZ06863.1,
RC ECO:0000313|Proteomes:UP000019112};
RX PubMed=25115770;
RA Dohra H., Tanaka K., Suzuki T., Fujishima M., Suzuki H.;
RT "Draft genome sequences of three Holospora species (Holospora obtusa,
RT Holospora undulata, and Holospora elegans), endonuclear symbiotic bacteria
RT of the ciliate Paramecium caudatum.";
RL FEMS Microbiol. Lett. 359:16-18(2014).
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Translocation stops specifically at Xer-dif sites, where FtsK
CC interacts with the Xer recombinase, allowing activation of chromosome
CC unlinking by recombination. FtsK orienting polar sequences (KOPS) guide
CC the direction of DNA translocation. FtsK can remove proteins from DNA
CC as it translocates, but translocation stops specifically at XerCD-dif
CC site, thereby preventing removal of XerC and XerD from dif.
CC {ECO:0000256|ARBA:ARBA00024784}.
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA.
CC {ECO:0000256|ARBA:ARBA00025923}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETZ06863.1}.
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DR EMBL; AWTR02000080; ETZ06863.1; -; Genomic_DNA.
DR RefSeq; WP_021827882.1; NZ_AWTR02000080.1.
DR AlphaFoldDB; W6TD61; -.
DR STRING; 1399147.P618_200976; -.
DR eggNOG; COG1674; Bacteria.
DR OrthoDB; 9807790at2; -.
DR Proteomes; UP000019112; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000019112};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 367..585
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT COILED 436..488
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 384..391
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 720 AA; 80720 MW; FDB5CB3F20EB18D3 CRC64;
MAFWKNSSFL SSVSHAVRDG VALLVLAFDF FLLVSFLSYS PHDPSWNICV RGVPDNLMGV
WGACVSDLFF QWFGLGAWVW VFFGFCVFVS IALGTFVWFW LRWSFLLSVF VSFFSTLFSE
KFGALLKMYP PGLGTWIKEG KISFWVGAVL CVYGIGCSLG LFLGDEFLKK WIIFFSRLKS
EKEDAQNMQE HVQGGSTDLK SKKDREPLKI SKLSKIKEEI IRAPSIYLNN PETALPPLEF
LTRNPGKGLL KTEIAQGSID RLQNVLEEFG IKGKIVNTRP GPVVTLYDLE PAPGVKSSRI
ISLSDDIARS MSVLSARVAL IPGKNLMGIE LSNVHRHMVY LHDLLNSPFY TDFQGQLGLA
LGQDIAGQPV IVDLAKMPHL LVAGTTGSGK SVGISSMILS LLYRLSPKQC KLLLIDPKII
DLTVYDEIPH LIAPVITDHK KALEALKWAV QEMELRYRKM SQLGVRNISG YNQKVQEAKK
ENQPLTREVQ LGFDSENRPC FQQQVFDTEF LPYIVIIVDE MADLMLVAGK ELEVLIQRLA
QMARAAGIHL IMATQRPSVD VITGTIKANF PTRLSFQVSS KIDSRTILGE QGAESLLGQG
DMLYMASAGR VMRIHGPFVS DEEIEKVVNF LKTRGSPEYI NMEIQEEDKI TGELLSQQDA
LYQKAVAIVY QDRKVSTSYI QRQLQIGYNR AARIIEQMEK EGIISAPNHS GKREILNNTR
//
