ID W6U7H4_ECHGR Unreviewed; 1570 AA.
AC W6U7H4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Sorting nexin-13 {ECO:0000313|EMBL:EUB57183.1};
GN ORFNames=EGR_07932 {ECO:0000313|EMBL:EUB57183.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB57183.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB57183.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB57183.1}.
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DR EMBL; APAU02000091; EUB57183.1; -; Genomic_DNA.
DR STRING; 6210.W6U7H4; -.
DR EnsemblMetazoa; XM_024497181.1; XP_024348379.1; GeneID_36343647.
DR OrthoDB; 5392990at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.330; -; 4.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF3; SORTING NEXIN-13; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00076; RRM_1; 3.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50102; RRM; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 177..248
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 273..355
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 377..459
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 467..542
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 548..729
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 1183..1304
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1128..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1345..1375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1133..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1570 AA; 175752 MW; FA0AEE9FDC54F4A3 CRC64;
MIEDRRVIND CLAAAESSTD SADVHSSGGS SSVVLIPCTL SLIQICQLFI FTPPISILGE
EWSPFCMFCN LPASQPWSQV VTSVSKSTHA LLKAKSDLKN MRDSLKAMFH SQMSRLDDFI
KQATMELKDA CSKSVDRSTA NLNALIAERQ NELATLKDRQ DESSKDDSST SNASTCKQIF
VGGILPKTNC MELRKYFSHY GTVEHAYISP YKLFGSVTFE SEESVRKAIS QPEHFICGRR
VTVEEYIPKK SLPVLEPQPY KKESPSTHPW EAQKVFIGGI STESTIATVR SALSRLGPIE
KIEMVPQQGF AIVVFKEPET AKLAISTRWY TVDGKRVEML PYVPDKKTRD ALARVTSSPQ
LMRQITPTPV LPPEKQTTVF VGGISWETTV DSLKSALSKL GPVQKVTLPP TRGFAIVVFA
HPETAESAIA THWHLIDNKK VELLPFIPNR ATKLKTLDSG VANSNARKLI IRGLDEGTTY
TALRNYFINY GAIDYVSATD TGSWVLFKNA ESVDLVLSTQ PHLIRGKKVE DFRPLHSRAK
YNYAISGCHE LDVVLNQILE YIIDDYVRCW YAQLTSESEF PGQLHAAMAQ LAGEVAKRAQ
RIDWVPFMIE GIPNMVIEHL RIHRRSLERR SLSNAEDPLK LFFDEEYEME KPICREDICT
SRAKELNHLR RVTDVFLFAI MPEDDYRIVA VRYLIKEILV NGVLLPAVNI LADSDFVNQS
IIKLCNESAF ASPYFIQSLR MSTREDELQT VKERIEIFAA KLRGRDSGGD DGSTTPNDRN
SCHTEFIPIQ TSLFQAEGNS GRGRNCVRVS PQQSFCAEHL GDTVYRATNL CESDSPEAMV
TTIHAGVLIN FFEPKLLYRH RKKAELLVPF CLFFMPIDAM VKAQLNSLNF LENICDSQIT
EIKRGPSRMP GHLMDAMASG ADVLSHTMVD FTFDDVMANN IAVSNFLEFL TSINEQSLLS
LYLNCVAYRV NSEELMSSIT SSTTDATTAP STTVSNVISD EGDEFGNALG WNESTEQVER
LEVEQHVMSA QDRETMEGIR AFGVSMCNLV MKILPQVPEA TVQQCLRSLT TPLESIDPTV
FVDVEEELIR LLSSEQCFGA FKKSPFYARA VEELEVSDLT ESPRRFAANN GEEVPDTTCS
SSISSSSSPI LSRAASSAVF SASSNSSQGA QSQFYSSSSP SSFYADSYSV NVLSGEMVRD
GYVVYTLEVT YLSSVSGRRS VWRTYRRYSQ FDDLHSCIIE QCGRIPTLKL PSKKSFSNIS
LEFIEKRRLE LDEYLKVLCS IDASGKYPKL HPILTSFLQP EKWERRKALH PGVSSLMNPL
KAMGSAIISV PDSLFDGFSK MISRRQPSDR SDVNGNAQTT TAATSSTNSR FSTSSDTYTS
NLFILDQTDS DNIPFRLLFM LVDEVFSLQR KTQLFRRGAL TILRNIVQTF FGDIMNRRIV
EKAKHLISAK KIATYAEMFR DVVWPNGSQV NGRSGNGDTE EPPIRDEAMK LRTRVLCRAV
MFGSVAEELA SYLGVETTRE GVQRVFDLLQ QPCLNRRLVH CLLEGVTRLL LPEYADQLND
IYAQDNCRST
//
