ID W6UEI5_ECHGR Unreviewed; 517 AA.
AC W6UEI5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Protection of telomeres protein 1 {ECO:0000256|ARBA:ARBA00015253};
GN ORFNames=EGR_05805 {ECO:0000313|EMBL:EUB59321.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB59321.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB59321.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the telombin family.
CC {ECO:0000256|ARBA:ARBA00008442}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB59321.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; APAU02000046; EUB59321.1; -; Genomic_DNA.
DR AlphaFoldDB; W6UEI5; -.
DR STRING; 6210.W6UEI5; -.
DR EnsemblMetazoa; XM_024495054.1; XP_024350517.1; GeneID_36341520.
DR OMA; WYNSPEC; -.
DR OrthoDB; 2999735at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd04497; hPOT1_OB1_like; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR028389; POT1.
DR InterPro; IPR032042; POT1PC.
DR InterPro; IPR011564; Telomer_end-bd_POT1/Cdc13.
DR PANTHER; PTHR14513; PROTECTION OF TELOMERES 1; 1.
DR PANTHER; PTHR14513:SF0; PROTECTION OF TELOMERES PROTEIN 1; 1.
DR Pfam; PF02765; POT1; 1.
DR Pfam; PF16686; POT1PC; 1.
DR SMART; SM00976; Telo_bind; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022895};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT DOMAIN 14..147
FT /note="Telomeric single stranded DNA binding POT1/Cdc13"
FT /evidence="ECO:0000259|SMART:SM00976"
SQ SEQUENCE 517 AA; 57565 MW; E83B594B11A6E349 CRC64;
MASSDVPPQH QYEFVDLRNI TEGRHNIIAV VKFFKPPQKT RGSGFSMFVS ISDPSLKGDK
FSVTVINNNV DKLPPIHSPG DIVIMHRLSV STFRGRLQGY GSENAGFAVA VFPGTVDSSL
APYESTSTCT FTDKDLSRVK ELRTWYNSPE CPLEKEAPQS LSPYKAQAEH DTHNLSRIHS
VKVNSFFNTE AQVVAIYTYP TEVTNDLILC LWDGEPPRDD LDLFPFYKLS DLEHPPSQDG
FQMDPRLICI TRHSFLPEVG DWSVCVFIFD EHAESVRSLK PGTLIRLHNL HCTAKCDPDK
RKVDMHGGGH RYGRRIELLT EETASADLLE RLRLGRMARQ PLNAASLSQD MDCLRMLTAA
QFYVVFNGHN PTDLGAVGES SSSFPVRIRF CGWVVDVVPS KSENILNHFL LKHICECEST
SSFDVLPVFL LELADFSGRV IAVSSTCGVE ALIGAHFPSF RACLRTVFKG ATVEERVKAA
EEIKEAWTAC VGGWVDATLL VLQNSCQSEA KVVYLEG
//
