ID W6UEL7_ECHGR Unreviewed; 590 AA.
AC W6UEL7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Chloride intracellular channel protein 5 {ECO:0000313|EMBL:EUB59498.1};
GN ORFNames=EGR_05648 {ECO:0000313|EMBL:EUB59498.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB59498.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB59498.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB59498.1}.
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DR EMBL; APAU02000043; EUB59498.1; -; Genomic_DNA.
DR AlphaFoldDB; W6UEL7; -.
DR STRING; 6210.W6UEL7; -.
DR EnsemblMetazoa; XM_024494897.1; XP_024350694.1; GeneID_36341363.
DR OrthoDB; 103277at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0004364; F:glutathione transferase activity; IEA:UniProtKB-EC.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00159; RhoGAP; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR43920; CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A; 1.
DR PANTHER; PTHR43920:SF5; CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A; 1.
DR Pfam; PF13410; GST_C_2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT DOMAIN 52..270
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 590 AA; 67059 MW; 8D77F8F28917FA2B CRC64;
MTQSRLSDSF QRLKKRCTFR RHSDGDVENA CRVKVKTSCN NKKAEFGPVY GADLSSQPQS
LEHPGVPRLL ELLVSALEAT GLDAFGLYRV PGRTSSIKVA IKFIKEQPND IENIFKLHDL
DNSSVLTSLI KRYLMALPQK LLDCGSWDSI VESISNEDIL SPMKLPEILC QIRTKIEKAF
GSAVESSDLR GGHQLSETQC RLATLRFVMD HLQRVIQAQK AKSVTYESFS ICLTPCLFGI
EAHCSKVLEI ILEHWNWIGR SLLLKPEDKS SFEILWDARR YVLGHYSRIA MEQPLVELFV
KASGVNWNDK GACPFSQKWF MVFYRLVECR MINLRVIPVS MANPPSEYSR LDMGKQLPSI
AFYSKPNDDE NAYDPPDFVC DGNDELEEFL RSKYGSVMNI DAQEQWVGAD LLRSLNHFLR
TGSSQQVLTN FSSVNEHLRK TNTTFLEGDD FAYSDCVLAC KLHHARIAAS FFRGLSIPSK
FSHLWSYMKA VYATRAFTVS CPLDRDILLH YLEKVDFVST EARNEAHHEI ITLPQDKMST
FIPGEDPEAS AQMPRLTCSG LRLFVNSVMP TMEFDRSLPN RISRLFSVVK
//
