ID W6UEQ6_ECHGR Unreviewed; 193 AA.
AC W6UEQ6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Copper transport protein ATOX1 {ECO:0000256|ARBA:ARBA00040962};
DE AltName: Full=Metal transport protein ATX1 {ECO:0000256|ARBA:ARBA00043201};
GN ORFNames=EGR_05740 {ECO:0000313|EMBL:EUB59386.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB59386.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB59386.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- FUNCTION: Binds and deliver cytosolic copper to the copper ATPase
CC proteins. May be important in cellular antioxidant defense.
CC {ECO:0000256|ARBA:ARBA00037651}.
CC -!- SIMILARITY: Belongs to the ATX1 family.
CC {ECO:0000256|ARBA:ARBA00038171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB59386.1}.
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DR EMBL; APAU02000045; EUB59386.1; -; Genomic_DNA.
DR AlphaFoldDB; W6UEQ6; -.
DR STRING; 6210.W6UEQ6; -.
DR EnsemblMetazoa; XM_024494989.1; XP_024350582.1; GeneID_36341455.
DR OrthoDB; 1107952at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR PANTHER; PTHR46365; COPPER TRANSPORT PROTEIN ATOX1; 1.
DR PANTHER; PTHR46365:SF1; COPPER TRANSPORT PROTEIN ATOX1; 1.
DR Pfam; PF00403; HMA; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 50..114
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 193 AA; 22005 MW; 33727717958BFB98 CRC64;
MIKPSAFLQG YCGVCHNKWP LRFAGMRSYF DLFSLFFTFL LKEHTSSAHL MIYNFEIEMT
CEGCASAVKR VLSKLGNAVS AVHTDVDKNT VTVTSTLPEK TILETLQKTS KPVKYSIIHF
KYLGKPVSDI VVSLHLVCTS YSFCLRSSCV FLYLDILLWI EAKYTLKKAK YISNSPLCYS
LKCPQFIFNL LYV
//
