ID W6UFV1_ECHGR Unreviewed; 782 AA.
AC W6UFV1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Delta-like protein D {ECO:0000313|EMBL:EUB60345.1};
GN ORFNames=EGR_04727 {ECO:0000313|EMBL:EUB60345.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB60345.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB60345.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB60345.1}.
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DR EMBL; APAU02000031; EUB60345.1; -; Genomic_DNA.
DR AlphaFoldDB; W6UFV1; -.
DR STRING; 6210.W6UFV1; -.
DR EnsemblMetazoa; XM_024493976.1; XP_024351541.1; GeneID_36340442.
DR OMA; ANRQPEC; -.
DR OrthoDB; 5475408at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0032502; P:developmental process; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24033:SF151; PROTEIN EYES SHUT; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF07657; MNNL; 1.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 70..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 299..330
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 371..413
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 415..452
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 454..496
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 498..534
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 320..329
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 403..412
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 442..451
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 486..495
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 524..533
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 782 AA; 86948 MW; 766C875D6B6EAE06 CRC64;
MRVYVASPFP EFAHSQSQLS VTGLYEEGAE TGAISQILGG HNHHCTHTHT YRQSSTQLEF
MLAMAIKTRL AYYVFLTLFC TLVAGGGIFE IRVERFQLDE NFPAAKCCPQ DDDEDADRSF
TACLAKCQFL VRVCLDKYQT VWNANRQPEC PLGSKVAPLP LAQLKKPLVN ISFPVLTTWR
ENFTLILDIL HGTGETNPPK LLFRLPSNEV NFTSHHHWKV KSFGSRSPLA YGKPHSQMAP
TQRGIGLSVL TTFTFKCSPG FSGPLCENKC DPEDSQLESA DCESDETRCP QGYKGQRCDI
PICTKGCQNG DCVDPDTCRC HQGWTGEDCS VCQVYPGCKH GSCSFDPKKN RQLPFTCFCE
DGWGGMLCDI DLQFCQNNKG VCKNNGKCEN VRSPSGQPYR CICLPGFRGD HCEMMQLDCL
SHGCRNGGQC TQHMDGQTRC ICPKGYYGNL CEFNQTVCSE HPCQAANSVC HPLSRPKNGR
QFYCACPPGY TGENCEINVD DCASEPCRNG AFCEDLISSY RCICPSGFSG IWCENREVEC
PPNTCSKGST CYKTKDGTFK CSPIKPLTSD KGSIVMVHLQ PSFLSLTIGI PVAVALSGLV
LAIAVCLFMA ACLWRREKTQ SKRKPPPQNF SPKFQLEEDM NGYASETSTV WSAYEPLNSL
RSDETTLPKL SLYPKLKGED KIKHLEPSLY HQQRYCEAPS NRPFSTVLSS TSTYETPCSY
EDTSVPTLPP RPSRIGSIIA YPPTFLRPIL YPFAPQATFP GQRFTKSPTD LAYTTLTEDN
KR
//
