ID W6UH05_ECHGR Unreviewed; 1248 AA.
AC W6UH05;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Tyrosine-protein kinase {ECO:0000256|RuleBase:RU362096};
DE EC=2.7.10.2 {ECO:0000256|RuleBase:RU362096};
GN ORFNames=EGR_04844 {ECO:0000313|EMBL:EUB60286.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB60286.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB60286.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001149,
CC ECO:0000256|RuleBase:RU362096};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. {ECO:0000256|RuleBase:RU362096}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB60286.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; APAU02000032; EUB60286.1; -; Genomic_DNA.
DR AlphaFoldDB; W6UH05; -.
DR STRING; 6210.W6UH05; -.
DR EnsemblMetazoa; XM_024494093.1; XP_024351482.1; GeneID_36340559.
DR OMA; MAYLEAC; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24418:SF421; INACTIVE TYROSINE-PROTEIN KINASE WSCK-RELATED; 1.
DR PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50001; SH2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141,
KW ECO:0000256|RuleBase:RU362096};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362096};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141,
KW ECO:0000256|RuleBase:RU362096};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362096};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW ECO:0000256|RuleBase:RU362096}.
FT DOMAIN 28..147
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 206..276
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 927..1221
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 959
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1248 AA; 138167 MW; 20EBF6E95E3804A3 CRC64;
MARPGVGGVR SRRQSGESAS ISPHSVSYFH GKITRDQAEA ALFAHKALEG LFLLRESVHQ
NYAISICHAP EAKTCSLRTC STASTPKYTV NEMKSKFSVV RLDTVVLPVL TEGISRKFPG
PVELVKHHAV QLDGFLTLAR FPLDRPTGES PIVLQGVRSD ELEEKLRLKA MEMGLKGPSV
TEALAGPMRD HLRYLVLRDL HFLQPWYHDC IRRRESERRL EENGGGNGSF LVRYRKEDGA
YVLSLMYEKE PRHYKIEQHL NRLSIEGGQY FETLIEGKHF QKEALTADEE RLASLTALEQ
AHHVSLTLQP PLLEVVVLCD GELASRLIET TTSATTSNHM IDHYHFRQDG LLCKLRKVVA
APDFIRTKQD AVIVHPKVHV KGKSSFLYYR SLATRRVYDN KGSGVKKGNA FFPPTKSVQK
EVFKFYTSLN KWSTWFLKRL PWVLAIACIK STQALCEIPP HNSLKNTGSS INNSKGASHS
LPSLASCPFN SATSDNLGGG SPVLRKVCDD VMHASNDLIS FNDWPNVTSL LANQDRVFRT
LNAYRTDRRC GRAGNGNTAA KIATTVQTAT RFYLVCTAQI FACWVAECPT TGLLGVLLSA
DFMPFHAGNL IRPNANSNAT INNNNNIGGG KLPQNNITVK RISAVPVAKF LRPNLPSLQS
VNLGYGDGFV HTPFTPVSTE ATPTPRPGTV TSSPTSPFSR VRLKPTFTST SVGTTVTTAT
TASNTIANEV SQPRPLQASV TCPLIPEVLR ATNNSNTGAL QRSPTTARFA QAQLPCKFAP
NNSLPPESLN FPPIIDALWE EPDGSEDRSQ PSSSLVSINV EALPPPPPHI LNPFIQRTSS
QTSVNLQPCH HAPGVSTFCN SACCQQKHQL QQKQQQQKAD EIVVEKIEKE EVSPTKPPSS
VLPAIEEAQK IYDSLPDNTL FLQPDSIRLM DRLGGGNFGQ VVKAIYKTPQ GQEVEVAVKT
LRESQIASTG EQTILSEAET MTQLKHRHIV RLIGVCKAQH FMLVLELAPL GPINKYLKKH
PDTPVWVLSE LMHQVAQGMA YLEACKLVHR DLAARNVLLV TQRFAKVSDF GMSKALNFGN
DYYREGVLVI LLGSEFHPVC KTLLENREFA GHHAASAGKW PLKWYAPECI YYFRFDSKSD
VWSYGITLWE VFSYGERPYK DMKGAQILAM LDQGLRLSRP VRCPEAIYAV MQQCWNAEGV
RRPTFAELVL TMSRLAKGPL FPNNFSGCHE NERGAGVSGE SVGAFAFF
//
