ID W6ULZ2_ECHGR Unreviewed; 847 AA.
AC W6ULZ2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Pleckstriny domain-containing family G member {ECO:0000313|EMBL:EUB62068.1};
GN ORFNames=EGR_03089 {ECO:0000313|EMBL:EUB62068.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB62068.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB62068.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB62068.1}.
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DR EMBL; APAU02000015; EUB62068.1; -; Genomic_DNA.
DR AlphaFoldDB; W6ULZ2; -.
DR STRING; 6210.W6ULZ2; -.
DR EnsemblMetazoa; XM_024492338.1; XP_024353264.1; GeneID_36338804.
DR OMA; DMILICK; -.
DR OrthoDB; 2881273at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR040181; PKHG5/7.
DR PANTHER; PTHR13217:SF11; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5; 1.
DR PANTHER; PTHR13217; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT DOMAIN 222..490
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 31..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..814
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..847
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 95021 MW; 040C90ACF8219897 CRC64;
MTISRDSSAG PVIRSSARPS RLDFGKTILA SRKAIPPQMS RDYDSETKMA PGGANACPSS
SEPPHSPTGF HSSCIRYRSK GSELITPERR SIYNGAYPEQ VFPSKASIRW QTGQMLARST
PDINAACNPQ ATRPPTYIRR RERSYDQIGS LMVQTDRLQN RLKDFEKGNL PKIPQNLLAV
FPQNLQRHDF SVIEKMWNQL TVEENQDTVV NPNDLSKKAK DLQLSAVMEL LYTEACYIKT
LEMLIDVHIA VYLDLTKSTT GSHDYASRSG SLNRLSMVPS MDPIVPTELG PSTPTASTAG
SHMHRRFRGR GSHDLTSCTS SLSNLSTLSL YDFPGFTAPP FEDVFGNIGT IYKVNHQFWT
DCFEPGITNE SAIDVKFCIR SMAKAFSQFA SYFHPYINFL ETYGTLISNI KYLDENNKFF
SIYHRWTRSN NPLNSRESLS GLLAQPFQRL TRYGILIRRI KETTTDEYET SDLTEMLEAV
EDFVKEVDVN QPKEESRTKL NEFIQRIHKY TTTDSIRSEL NMELPAGSAD IRSILRQPMR
INGRLRTRKP IAEVQAKVKY TGGKISNALC MLLSDMILIC KHSVVRRRIY VHRPPILLNN
LTIQNKWDDP NSFAGIVTND LGLVVDAYLF SSDGKDLKGW IYEVQQQKAK MVAMQQPNPV
NQDVLSGFWQ CHSNTGPSLG GLPPRKYDYN RLTSYECHSY ITNRGIKRCG EVSRRPFLES
FANSNGVIGR PQQLVDGSTL CSSKRPILPS RAISESETTL LERMKNGSSA SVSKSASSAS
DSSAFSSSTS NTTNTATTSM SEESLGSIRS SPPTAVASKV RRPPRRMMKR GSTELVKTDS
TDKRMTH
//
