ID W6UMB8_ECHGR Unreviewed; 4796 AA.
AC W6UMB8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 08-NOV-2023, entry version 41.
DE SubName: Full=Dynein heavy chain 5, axonemal {ECO:0000313|EMBL:EUB62286.1};
GN ORFNames=EGR_02739 {ECO:0000313|EMBL:EUB62286.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB62286.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB62286.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB62286.1}.
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DR EMBL; APAU02000013; EUB62286.1; -; Genomic_DNA.
DR STRING; 6210.W6UMB8; -.
DR EnsemblMetazoa; XM_024491988.1; XP_024353482.1; GeneID_36338454.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF4; DYNEIN HEAVY CHAIN 8, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT DOMAIN 2122..2259
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2402..2557
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2730..2878
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 887..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4493..4517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3342..3383
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3577..3632
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 892..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1082..1120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1137..1169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4796 AA; 545957 MW; E3D974618668B4CD CRC64;
MPGGFPSQRG ERIRGARENR RALIDDRHLN ILMRLERAFG VETQTASEWL LDFGQLEALN
IFFEANGAKV LMVTYADQNF NVHSTAKEAF KIQKKNLRGT KRYFFHNGQL PLKTETYETF
TCKLDPAAGF VIPMFDYLRN FILPGVQVQA ANMHQLTPRQ HDDYCDYLAN YINSLETVIA
CSQEHVILPP YMLHEQVHFN DMEGLIALSK TPEGLSLLEE NASAWMKKIY EEAKAVELIH
VEINQTGPDG EFRFWKCQMT RMNSLVQELS RPDIKNVISV LEQAKSTIIP TWVQLDKKVK
YANAEAAGNV KYLSAVEKLC APLVVTDIKT IISWMPNLMK SLKLLFQCSP FYNTYSHMTV
LLVKITNQII YICKRYLTYN GTKSIWEQDN DEMVARMTDC IEVNLAYQTA YRVTRQGMID
AKEKRIFNFS EVQIFGNMNL FTQRLDYLTR VLKTLKQYSV LHEFVLEGKE PMIAKFDRLK
SMIASRPYDY LDHRNSMFEA DYDEFKERIS EIHDMLLSTI SANFTKPSSL MNAVRLQERL
ETINIPGLEH GTRYRQLCDR LMQEINNIMD QFQTNFASPP LGRNMPPFGG RIAWARNFYR
RLEEPMNAIC TKAPKALISP DGQDLVSAYN EVTGKIVGYE IAVYQTWTKL ILKKLNGLSA
SLIVYSHQPA PFGRPFVNLD PDIIGLLREI FVMDKLQCPI PSFAKETLLK AKYIKYHYEQ
LKYMCGRYVQ ITSSVPEKYH VLVIPSMMRV NRALEPGMHL HNWNSITTMN YVNNVLSTLT
EFERLLKQID DISVNRIDFV LSELSQTTIL SLPGPDDPAL EIFDLVRLAK GQILAAADTM
NALTITVLKA TVEMLNILLE DYDKFVDENN LEKIIADEVQ IRYAHMENQE PNGGGPNRTK
AANSEAATSG KAAVVTKGNN GGVESQTATQ TKEDLKLPPE VHASLKTAVQ VALAADDMMM
NLGTRATEAV CQSVRTALDS IWSRLAVKEA AGILKDIPAG MKVKAESTRP QPLVRCYARL
VGTQVDIWPR PAEIQAALRS IVGGIEGSCK GVLAWGMDGR KREINEKVLT AGPFDNELAH
DGTSVTAGSN SQTSADEKHV SMFVPSSNSS THTEAGETEN SLSPPGPPGP SASTWGAEVE
GGSNADTQGL PGSGGGTNSD SNSRKMRGSR NTLFAKQITG MLETDITLRF NTYKEVHGDR
EIYRLRNFIS SGLQQMKKIV FQNDGFIYET ESLTSYLEQF SHIYKCDVDA ELEAFLGAEP
CMHEFQMKFS YLQSFEEQIE REPDHYVVGA LYVGLDDFKR KIRITLNALK KASCTSPLKS
HSNFLRDIIG LSFLRLLKNY VQAFISEFIS PLDEIQNQIE EWDRNLAKKI TNLDDIAFVM
DTLADIREKD IKQDMTLLRC EDATNLISKY NMPFPKELSD RVESCRYAYF RIKEKALQKL
DHLLSIQAGY RDGLLESIKA LKELVEEFET DYDEKGPMVP GLPPQIALDR QIQFKNRHDN
LTRKMLTARK GEELFGLPIT DYSRLGGIGK ELDLLQRLYG LYNEVSKTVS GYYDIVWRDV
NMEKIAADLE EFQRKCKRLP KALKSWPAYT DLEKTINDFN EKVPLLEMMT NKAMKPRHWQ
RLAALTNYNF DVESESFMLK TMLDAPLLES KDDVEDICIS AVREKDIEAK LSGVIVDWTH
QELKLASFKA RGELLLKGDR VSEIVPMLED SLMILGSLMS NRYNVPFRKP IQEWVQKLSV
TSEVLENWMR VQNLWVYLEA VFVGGDIAKQ LPQEAKRFQT VDKAWVKVMD RARDNPNVVA
CCAGDGSLTE ILPRLLNQLE VCQKSLSGYL EKKRLKFPRF FFVSDPVLLE ILGQASDPTA
IQPHLLAIFD NTKSVLFSEK APDILAAFSS EGERLDMFAP VKCEGQVESW LNTLLITSRL
SLHLSIQKAS FLIMDPSCEL IEFFTAQLAQ IGIIGLQIIW TMDATEALKE AKVEPKAMTK
TNKHFLDVLN LLINETTKDL NSLQRTKFET LITIMVHQRD IFDDLASGQI HIIFTYSYVL
PNYLQQFYEY LVKQGIKSPD DFEWTKQTRT YFNEEVDACV VSITDVDFAY QNEFLGCTER
LVITPLTDRC YITLSQALSM HLGGAPAGPA GTGKTETTKD MGRCLGKYVV VFNCSDQMDF
RGLGRIYKGL AQSGSWGCFD EFNRIELPVL SVAAQQIAIV LSAKRDGMSS FIFTDGDEVS
LDPEFGIFLT MNPGYAGRQE LPENLKINFR SVAMMVPDRQ IIIRVKLAAC GFVDNIILAR
KFFVLYKLCE EQLTKQVHYD FGLRNILSVL RTLGSARRKN PKDSEDRTVM RGLRDMNLSK
LVDQDEPLFN SLIDDLFPGT ILEKATYPEL QRAIENATSQ FNLINHPAWN LKVVQLYETQ
NVRHGMMALG PSGAGKTACI RTLMAAMTEF WEPHREMRMN PKAITAPEMF GRLDVSTNDW
TDGIFSTLWR RTLKKKPNEH IWLILDGPVD AIWIENLNSV LDDNKTLTLA NGDRIPMAPN
TKILFEVHNI DNASPATVSR NGMVFMSSSV LEWDPISKAR LNYRPDNERR KFHELFQNSF
PQSYRFVSQT LAIKMPYLEA FFVHQLCTLL DGLLVLENQQ GNTDKYLERI YIFALMWSIG
ALIELDDRAR LEKFWRTELS VKLDLPSVDD SKSETIFEYF VGPNGEWVHW SSRIDEYIYP
TDKDPEFSSI LVPNVDNIRT DYLIRLVGKQ EKAVLLTGEQ GTAKTVMLSK YMASFPIDAY
TFKSLNFSSA TTPGLFQRTM ESFVEKRVGT TFGPPAGKKM ILFVDDISMP MINDWGDQVA
NEIVRQTMEM RGFYSLDKPG EFTNIVDVQF LAAMIHPGGG RNDIPERLKR QFACFNCTLP
SNNSIDKIFS TIGLGHYCQA RGFTEEVINM VRDLVPFVRR VWQQTKTKML PTPAKFHYIF
NLRDLSRIWQ GIIYGTSEVF TTPDLLIKLC KHEMTRVIAD RFIDPADLIW FDRNFNRTLE
DMMGEEVASS AQDEVFFVDF MRDPPEATGE EGEDFDFSAP KVYEPIFELG VLVDRLNNFL
RERNESVRGA PLDIVFFRDA VIHLVKVSRV IRTPRGNCLL VGVGGSGKRS VTRLATYIAD
YADFSIVLTR SYNVNDFLDD LRTLYRKAGQ EGKGATFVFT DSDVKEEAFL EYMNNMLTSG
MVSGLFSRDD IDDILNALIP VMKREFPRRP PDIETLNEYF LQRIRKNLHI CLCFSPIGKR
FRTWALYFPG LISGCTIDWL HKWPKDALLA VAKQYMGNFN IESSASVKER VIDLVATVHD
GVAIKCEQYF ERYRRTAHVT PKSYISFLSG YSKVYGQQLA NIQSLINRLS SGLQKLDEAQ
ESIAKLSVEL VEKKKELQIA NAEAEVVLSD VMQQTQAAEQ VKNKVLVVKN KCETIVSSIA
AEKLVAEGKL EAAKPALEEA EAALNTIKPG DIATVRKLAK PPHLIMRIMD CVLLLFQRPL
LPFQEDPDRR GCMKPSWNDS LKLMANTNFL QNLLNFPRDY ITEETVDLME PYFMAEDYNL
ETAKKVCGNV AGLCAWTTAM EKFYWINKEV IPLKDNLAKQ EIKLNAAKID LAKAEAVLEE
KERQLSIVRA LFEKAMLRKK ELAEDAEACQ KRIATATTLI DGLSGEKVRW TEETRTLGDQ
VIRLVGDVLM ATAFLSYCGC FNQDFRNRII NSWVKSLMKM KIPHTHNLDL INMLTEGPTI
AEWNLEGLPS DDLSVQNAII VTQASRYPLL IDPQSQGKNW IIKHEAAHNM LVTTLEHRYF
RTHLEDSLSQ GRPLLIENIG VDLDPVLDNI FDKNFLKSGT GLKVKVGDKE VEISPGFTLY
ITTKLPNPAY SPEIFARTSL IDFTVTSKGL EDQLLARVIQ TEKEELEQMR INLIAQMTAN
KRRILDLEDN LLMRLASTEG SLVDDQGLVD VLQTTKSTSI EVAEQIALAQ ETETEITAAR
EEYRPVAARG SLLYFLLSEV SAVNPMYQTG LGRFLKLFDE SMELSEKCVV TARRIINIIE
YMTYSVWSFA VRGMFKLDKT MATLMLALRI DLQRKAVRHE EFMVFIQGGS ALDLKTCPAK
PGKWISDLTW LNLVALSKLT EFSSIVQQVT STEKQWRLWF DKEAPEEETI PCGYEHTLDV
FRRLLLIRSW CPDRALQQAK KYIVHSLGQA YIEDVPVNII DLSNEADART PLCGLLSMGA
DPTPFIEHAA RKVRINLGVV SMGQGQEIYA RRLLKTAIVE GNWVLLQNCH LCIEYVQELF
EMLTTFVHDQ FRLWITTEEH KMFPINLLQI AIKFTNEPPE GIKANLTRTY LGITQDFLEI
CVTNHWRIIL YSLAYLHCTV QERRKYGPLG WCIPYEFNQS DFNASVQFLQ NHLDSLQFKK
GQRISGIDWK CTCYMISEIQ YGGRVTDDFD LRLLKCLTRN SFQEAMFSPE YTMVEHYPIP
LFGTVAEYLN YIKNDLPPRD SPEAFGLHTN ADINYSTQTT RRILATIVSI QPKDDSGDLG
DGKDEDDSDT GGTHKPAVET REMIVHRICT ELLKKLPPPY IPFQVAEQLK ALGALKPLNI
FLRQEVQRMN KVIKLVLATL TDLRLAIDGT VVMNEDLRDA LDCIYDARVP AFWIKSSWDS
STLGFWFSEL LERNTQFSTW LEKGRPLYFW MTGFFNPQGF LTAMRQEISR SHEGWSLDSA
VLSSHVTKLN VDEVREPPPE GVFVYGLFIE GAAWERRSGR LIEARPKILY EPMPVIHLFA
VQEGKKTVVG RLPYTCPIYR KPKRTDLMYV TSLDLACSKN PDHWIKRSVA LLCDIK
//