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Database: UniProt
Entry: W6UN84_ECHGR
LinkDB: W6UN84_ECHGR
Original site: W6UN84_ECHGR 
ID   W6UN84_ECHGR            Unreviewed;      2470 AA.
AC   W6UN84;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-SEP-2017, entry version 20.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=EGR_02129 {ECO:0000313|EMBL:EUB63035.1};
OS   Echinococcus granulosus (Hydatid tapeworm).
OC   Eukaryota; Metazoa; Platyhelminthes; Cestoda; Eucestoda;
OC   Cyclophyllidea; Taeniidae; Echinococcus.
OX   NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB63035.1, ECO:0000313|Proteomes:UP000019149};
RN   [1] {ECO:0000313|EMBL:EUB63035.1, ECO:0000313|Proteomes:UP000019149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24013640; DOI=10.1038/ng.2757;
RA   Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA   Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA   Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA   Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y.,
RA   Wang S.;
RT   "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL   Nat. Genet. 45:1168-1175(2013).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EUB63035.1}.
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DR   EMBL; APAU02000009; EUB63035.1; -; Genomic_DNA.
DR   Proteomes; UP000019149; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000019149};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     13     31       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    343    368       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    480    501       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    513    535       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    662    678       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    698    721       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    788    811       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    861    887       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1038   1061       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1081   1104       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1125   1153       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1211   1229       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1250   1276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1327   1345       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1357   1375       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1395   1416       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1437   1456       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1498   1516       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1634   1659       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1795   1829       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   2470 AA;  279788 MW;  22FB81771DC6C500 CRC64;
     MYIMKVINRV IEFIWGSWVI LTSAVSVKLL VWGELPFRLK LCALNLENRL FHKHQTYKIN
     YARQSGYPAS PSANPHGSYS SEEEEGGENR WRGAGKSRAA IPRIELPSSS APPLSSPTPL
     QSSTQSNQDA IVGSLGASIR AGGGSTLRGI AGVAAAAATQ QGKPLNLTNL ALAAQTNARK
     RPASRAQAAG SRPQRALFCL SLRNPLRKMC IGIVEWKPFE YLILITILGN CFALGSHTPY
     PDGDSNGTNS ILEKVENVFI VIFTIECLLK IVALGFVMHP GAYLRNGWNI LDFTIVCLGL
     LQPLLQRMLD RSGVDVKALR AFRVLRPLRL VSGLPSLQVV LNAIIRAMVP LLHIALLVIF
     VITMYAIVGL ELFSGKLHAT CYDIYTGESF VCNFRYLPIF SFFGEIMDNP TPCSLGRQGH
     ICKFPFVCHD FRPNMTKAAI AERRVIVANM SADPYAFTGF IKLPERWPGP NYGITNFDNL
     AASMLTVFQC VTMEGWTNVL YWMNDSQGME WPFLYFVSLI IIGSFFVMNL VLGVLSGEFS
     KEREKAKKRG KYQKAREQMQ FAEDVQGYLD WIGAAEDLSD DEDNVNRLDV KEKRFNFCGL
     CRRSQGGEDE DEDDSDRDDC GYRTQSSQQK QYFFCFPIRG RRSRRLNRRC RRSCRRMVKS
     QTFYWTVIVL VFLNTGVLTS EHYGQPKWLD IFQNDANVVF VVLFTIEMLL KMYSLGVRCY
     FDYMFNRFDC FVVICSILEI VFIMTKLMPP LGVSVFRCAR LLRVFKVTRY WNSLRNLVGS
     LLASMRSIAS LLVLLFLFIV IFALLGMQIF GGRFNFLSLR KPRSNFDNFY QALTTVFQIL
     TGEDWNEAMY MGIKSYSTQP FGSLVCLYYV VLFICDILLN VFLAIAVDNL ADTGQSKGKQ
     KSEATSEDGD DNTAGMDIVK SADGDSFNSA EEDGKSKVLL LENNENEEYV SIEERDNESE
     SVYSDEHHGS AENLQPKIKP IPEASSFFIF GPRNPFRVFC HYICNHPYFN NVVLVCILVS
     SAMLAAEDPL KANSYRNIIL NYFDYFFTSV FTVEITLKVI TYGFAFHKGA FCRSANNLLD
     LMVVLTSIIS YPIALDTISV VKILRVSRVL RPLRAINRAK GLKHVVQCVV VAVKSIGNIM
     LVTFLLEFMF AVIGVQLFAG KFHYCNDEAR FYKEECAGPF IKYDSEDPSL PELVERRWIN
     YPLNFDNVPN GLLTLFVAST FEGWPALLYQ SIDSYAEDHG KVYNCRPVVV IFYVAFIVVV
     AFFMVNIFVG FVIVTFQQEG EQEYKGCELD KNQRKCIEFA LKARPVRRYI PKERFQYRIW
     WFVTSQPFEY CIFIFILINT ICLGMKNTAF LHKVKSIVVI NALCVRVLVT ILQDLCSHFQ
     FEGQPPVYAD ALDYLNMIFT GVFTVEFILK LTALSFKASP HSYLIRFGNY FNDLWNVFDF
     IIVVGSFVDI VLSHIAENSK FISINFFRLF RVMRLIKLLS RGEGIRTLLW TFVKSFQALP
     YVALLILMLF FIYAVIGMQM FGKIALNNPD SAITVNANFQ TFPQAVLILF RSATGEAWQD
     IMFSCAGVSC DLLHVIAPCY PHSLALFPPF SHYRQIDVSS RGWCATETAY CDKQSDESRT
     AVGATDRTVC GSAFAYPFFI SFYIICSFLI INLFVAVIMD NFDYLTRDWS ILGPHHLDEF
     VRLWSEYDPE AKGRIKHLDV VTLLRKISPP LGFGKLCPHR TACVTLVRMN MPLNSDGTVM
     FNATLFALVR TNLKIKTEGS TPDQLNEELR AVIKKIWKHT SPKLLDQVVP PAGSNDDVTV
     GKFYATFLIQ EWFRRWKLKK AEEHKHLPYG QGRSLMHPEE EKGGGSSASD DKRQMSLLGS
     MMHALQRVGS YRRSSSSPQS SPAPAGANGA NTPAPPSPSK PPVIGSSGTP TAEASRVRKA
     PPTLQVPTIN QAPKEISFPN SIDQRKNTWD TLQARDPDMT EPSSEISEAI PLKQPYGTRK
     ELGNPSNVAH EQSYAYRPSV IQRIGPLNLP VLPASMGNRE TASNSSKILS QAFELPLPQY
     GNYQPRKLSS VIPRLMKKNI ANVVGTKCVD RKVNASCPSE RYAYVKKLDH GRKYPDNSDE
     EAQKNENVHL LHFSKMEPRF SRALGAPDTV GPLLDFQKDI EVVDNSFGEE LETTVMPKEA
     EEELDFDASY FSRGDTPSPA PSVSVPSSTY VFSGFSKWAG GLEREDRQMR GPRKAMKSPT
     SSEGRSHRRQ LPSIPDSLQR HSTREEYRPS THSLDTAWSR SSERRQRQRS DSPGAWTIAH
     TPTIFKRELN LRLDGSNDTK YEENDDDDVF FASQFSELNR TNLSQPITPH YGTLESYDFQ
     SMRRRPRQIL QHSFIDKRRW DAPFEHQFKQ MPSCGPPPTM QQRNHQSPHA WSYRHPPSLA
     PPPQSILHSS HLYTPERSSI HQSFQLQSER HWQQQNAGRP LVHTRPWPQT NGLDPGTWKV
     NHPPVPTPSK
//
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