ID W6UPG4_ECHGR Unreviewed; 1147 AA.
AC W6UPG4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Inositol polyphosphate 5-phosphatase {ECO:0000313|EMBL:EUB55309.1};
GN ORFNames=EGR_09836 {ECO:0000313|EMBL:EUB55309.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB55309.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB55309.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB55309.1}.
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DR EMBL; APAU02000170; EUB55309.1; -; Genomic_DNA.
DR AlphaFoldDB; W6UPG4; -.
DR STRING; 6210.W6UPG4; -.
DR EnsemblMetazoa; XM_024499085.1; XP_024346505.1; GeneID_36345551.
DR OMA; YQSHEDF; -.
DR OrthoDB; 21647at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016791; F:phosphatase activity; IEA:InterPro.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.30.29.110; -; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR031896; INPP5B_PH_dom.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR048869; OCRL-1_2_ASH.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF299; PHOSPHOINOSITIDE 5-PHOSPHATASE; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF16776; INPP5B_PH; 1.
DR Pfam; PF21310; OCRL-like_ASH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00128; IPPc; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT DOMAIN 936..1134
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 238..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1096..1119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1102..1119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1147 AA; 128267 MW; 3537F0870DB1A0AB CRC64;
MGKNGEDFAL VIQEFIDVKA RQDGVSRECN EKCLVAFEVS VVQSWVDVPR IVALIRNEEN
KQAVLFVFAG TRIADTVVSY LTTDKLIAVD RVFSCESDST KPTMLRVIGR DISSFRSDSV
LLGSTLPSKN RTLSVSQKCQ TTTFSTGLPI IRKKTRFSTL ILGFDDATSA NQFRTELNLE
LSNQADSLPL AASSTNWLDK YRADIATPSH TPSLSHLNRP LRTARSFADI AHDGTSTVPT
PFSSTSCSST SSESLKDVED GKIGPISNEE AVEHVRRTVS VPYLLEEEEI EKGQDAITAL
ADSNWISGDC STTELNAPLP TVTMTANARQ DIEDLPRTSV VEPAEATRAE QNGRRISRIS
FMSDSMFRAR MSADPIVRSK LEEDEAVYCT WKTLNLFIGS WNVNGRQDSL LRLDAWIRPP
PGCPPADIYV FGFQELDLNL AGMALNKQTA SPFESKWLWL LEASMEDLLN PSSVRSVTLR
RWVRRSGGGF KRLSIVRLAG LLLVVYVSNR LSQQAIISAI AVQSVPTGMF NLMGNKGAVG
LRLTVYNHSL CFLNCHLAAG PASCERRNQD YGEIMRKMMF ERRSLQESPQ YLLVNDHDQV
FLFGDLNYRL TGLDVNENLA AIARKDFDLL VKFDELSQQK AQRRVLQDFS EGKIAFPPTY
KFDLTSDSYC ITSWWTFFFR FSHLEILPNK YPTLSPSDLI SFSREGRVPS YCDRILWQGK
FVDLLRYQSH EDFRLSDHKP VSAYFKIGAR CVNQQLFMRA YEAVIRSQDL FYNMLLPQAA
LSSQEVDFGP VQFEDIRTQT IRLTNTGHSG LEFTFTQEGP AAFPPWLHVA PLNHRVEKGE
SCDISLDVCV SPDVVATVQS SISLLSCIIV LTLVGGKDFF VSITGRFVPT SFGLPLTLLL
RLPATPVALL PPDHIVQLIR ESRVNNWSDG EPSVVISTSG SILAIPKEIY RLTDFIAARF
EEPGLFRQPE IRSDLPIIRD TLDTTKHDVP IPSTVSVHSV IYSLLVFLSA LPEPVVPFAF
QSNCVAAARQ ATSNNVLPAY QAISRLPIDY QNLFFYLVSF IKRCLSHSEK NGTNVYMLAT
TFADILLRDP PYAASPPTAP GVRNGPSRNA STRNQQQQMA LSRHELKTAF LRIFITSDTE
EVIRRLK
//
