ID W6USU8_ECHGR Unreviewed; 1113 AA.
AC W6USU8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=tRNA 2-thiocytidine biosynthesis protein ttcA {ECO:0000313|EMBL:EUB63751.1};
GN ORFNames=EGR_01374 {ECO:0000313|EMBL:EUB63751.1};
OS Echinococcus granulosus (Hydatid tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC Echinococcus granulosus group.
OX NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB63751.1, ECO:0000313|Proteomes:UP000019149};
RN [1] {ECO:0000313|EMBL:EUB63751.1, ECO:0000313|Proteomes:UP000019149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24013640; DOI=10.1038/ng.2757;
RA Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL Nat. Genet. 45:1168-1175(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB63751.1}.
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DR EMBL; APAU02000005; EUB63751.1; -; Genomic_DNA.
DR AlphaFoldDB; W6USU8; -.
DR STRING; 6210.W6USU8; -.
DR EnsemblMetazoa; XM_024490623.1; XP_024354947.1; GeneID_36337089.
DR OMA; CATVDPQ; -.
DR OrthoDB; 5471897at2759; -.
DR Proteomes; UP000019149; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01993; Alpha_ANH_like_II; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000192; Aminotrans_V_dom.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR43686; SULFURTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR43686:SF1; TRNA-CYTIDINE(32) 2-SULFURTRANSFERASE; 1.
DR Pfam; PF00266; Aminotran_5; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 109..470
FT /note="Aminotransferase class V"
FT /evidence="ECO:0000259|Pfam:PF00266"
FT REGION 665..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1113 AA; 124621 MW; 12EAAE7B3E9C681C CRC64;
MDATSAADRL ASGHRQFYTL PKIPDLSSVD SAIYRILSNN TRSSISEGQN EADNRGFENN
EDFFDYINRS VIGYNKVFTS VFGDRRVIYC DYIASGRSLS FIEDFIYNEV LPDYGNTHTM
TSVTSLQTTM YRHEAKDIVR NAVRASDYDA VFFVGSGCTG AVHKLIHNLH LEKPPIVITG
PFEHHSNILP WRHMAAKIVR LNTDKCGNVS IHHLEEALST ERRRANELGC SLIVCLAAAS
NVTGILVDVD KFSALVHRYG GLVFWDYATA APYVKIDMNP VVSGPNHGLV CKDAVYFSMH
KFVGGVQTPG VLIAKRILFK AGERHPDGCG GGSVCFVRRD HQVYLKDVEE REEGGTPAIV
ESIRAGLVMQ LKEAVTPEVI VAREEAIVKR AWVRFKSSPN LLVLGGDEAP RLPIFSVVVR
HVFPDVFMAG KQQELMPCDR PMFLHHTFVA ALLNDLFGIQ CRAGCVCAGP YAMDLLGIDE
PLAKLYEDAL VTSEVSVCRV QKTYDKASSE VLRPGFTRFS IPYFMSDEEA NFVLEAVCFV
ADYGWAFLPL YSYDAMTGEW KHRQHDQLED RQWLGHIKYT KEGMTWRRAK IKARGALPKS
LQECLMAAKV ELKRAVDFVK SAEVSPVPDV TANFDAIGQK LRWFVLPCEA AAQMRGEISQ
LAISTGPSSP WKPGTMDPCT NVPAFTTSQK SLTSHRRSAA TTSPIDHQAT PSSSHAAHHR
SPVGSASPRH RNRRPHSSSP QHLFSLARPM SPNFSTLHNE PKSHAKYKNN VQQENNSHIN
CESTVRVINQ RPRSTPCDST AGRLDSEDPG ESKLVFREFK GLYDLSSMTR GSGEANLRVN
RWEERTLWRR PFKQLYRPFV KAIKDFDMIH RADRILVCLS GRKNSLSLLH CMHAYQEVCL
RRPDYPSFEI GAVTVDPGSS AFDPRPLIPY LAGLGVKCFY EEQNIMAKAS QLGNQCSSIC
SFCSRMKRGR IYAVALRHGY NVIALGQHLD DLAERTRNLR VIRPFVYIRE RVTRAFAERA
GLPIIPKNCP ACFQMPKERM RAKRVLSDYE NTFPNLFSSL QAAMLPLIAR DAALGLSAFE
DAEKAIASKA RETSVNSDFY EGQPLSCPRL ITK
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