ID   W6UVW3_ECHGR            Unreviewed;      1231 AA.
AC   W6UVW3;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Tensin {ECO:0000313|EMBL:EUB62552.1};
GN   ORFNames=EGR_02684 {ECO:0000313|EMBL:EUB62552.1};
OS   Echinococcus granulosus (Hydatid tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC   Echinococcus granulosus group.
OX   NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB62552.1, ECO:0000313|Proteomes:UP000019149};
RN   [1] {ECO:0000313|EMBL:EUB62552.1, ECO:0000313|Proteomes:UP000019149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24013640; DOI=10.1038/ng.2757;
RA   Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA   Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA   Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA   Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT   "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL   Nat. Genet. 45:1168-1175(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EUB62552.1}.
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DR   EMBL; APAU02000012; EUB62552.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6UVW3; -.
DR   STRING; 6210.W6UVW3; -.
DR   EnsemblMetazoa; XM_024491933.1; XP_024353748.1; GeneID_36338399.
DR   OMA; PMNDSSE; -.
DR   OrthoDB; 3439226at2759; -.
DR   Proteomes; UP000019149; Unassembled WGS sequence.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR45734:SF10; BLISTERY, ISOFORM A; 1.
DR   PANTHER; PTHR45734; TENSIN; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000019149};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          876..986
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   REGION          138..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          425..451
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          479..502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          596..643
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          679..700
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          764..863
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..218
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        618..643
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        764..862
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1231 AA;  135559 MW;  84C2125FA3BA16B9 CRC64;
     MRFAVARVQR GVAMRAGAGA PDLLLPSLSV THFPGVTHRT LGPPVAPFGT PHMIRPPCTM
     QLRSYRLQLH QPASERSTPT IIEEQEAEDF EEAEYRQLQQ EGYNFSQHLV GNSGVMSTTA
     TTQDLDQLLE ELRRTSLDYS STSTRSTAPH PNGTHSSRLY SGYQRPNFTE SSGGSTAGRY
     SARSYSFTGS GGSRPGGRWT NTSSSTSSSY QRSQAYSTER GMGEKRGTTT GEGGGFVRHA
     TPAPQLSSSQ QQRYQTTFRT TLQHRPPVSP KWFNQINVTI DPEFGTASSS MVSDNRGYLT
     PSVSRAQQTS TTAPMNDSSE MMSYRELQLL EELSSARQEL AMLKRASSVI EEPIHRLPPP
     STLPTQRRAF QQHHENVEMF SNRHQAHYQS HHDIQQGSNF YRPYGRYESM SKRMHTSVEV
     YSKLPPLNSR QRAATTKGPL KPRYSKDQHH DHKNGICDYC WNLDVPRTPT LLDETSAGLS
     DNPFTEDDEE IDDGAFSDSS LSSCLDEEDI PYSYGPASRE DGSFEKPYKM TDMRRTSIPV
     EYSGFAFGAP KRAMSSANVT TNQSWNYRNG MMSGPQSPAP GYSSIRSIGG SMRSGGMLSN
     SQGYSARRER LRQEAEQAEA LRQSTQRINH VSAASSNDLR STSLHQQRRQ HYHSMSTIQP
     ERTEFEEIET VTLQPIGRGV QDLSSNMGST ATLNRSTRRP VASSMLEGLN RTGNYTGARQ
     QRVNMAPFAH QTSAMDIPQT MSAKPQRAAS NSFLSSLRRH SAGTVSEASS FQHHVATTKS
     TNLATQQIRH QQQHQQNHSQ LLQTSQQGSK YVPVLQQQPQ PQPQQQSVLF QSQQQQCQQR
     TRNDVGWPSQ QNSTSSTLTP SGPADLALVE ATSPVWYRLK ISRQEAISIL KNQPPGSFLV
     RDSTTFKDAY GLAVKSTKPP SKTGQKSDDI NNDLVRHYLI ETVTTPNRGV RIKGFSAEQV
     FPNLLALIQY HTQYPVALPC CLVLPPIPPS QTGAVITSSN STFVRNGTGS GSGTGNGDSD
     SVTLVQNSGI RSLDQTPVSF NGNAVVTETL EAPPPARSIT SPLSPTAGMF HSELLSPPPS
     ISCRCLHLGA VEVDASQEQA SLMQAVDTLV PGSVLQAATC DQMGAESPVQ YTECQLQAAH
     NEGILLTDLS RKLFFQRHFP ANSFIYAGVD PRDKAFIHPN HSALGLDKPK LFGFITKKLG
     GEYMIQVFSE FDANCSAAAV TAQINSLLLN K
//