ID   W6V767_ECHGR            Unreviewed;      1070 AA.
AC   W6V767;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Gamma-tubulin complex component {ECO:0000256|RuleBase:RU363050};
GN   ORFNames=EGR_02742 {ECO:0000313|EMBL:EUB62289.1};
OS   Echinococcus granulosus (Hydatid tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus;
OC   Echinococcus granulosus group.
OX   NCBI_TaxID=6210 {ECO:0000313|EMBL:EUB62289.1, ECO:0000313|Proteomes:UP000019149};
RN   [1] {ECO:0000313|EMBL:EUB62289.1, ECO:0000313|Proteomes:UP000019149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24013640; DOI=10.1038/ng.2757;
RA   Zheng H., Zhang W., Zhang L., Zhang Z., Li J., Lu G., Zhu Y., Wang Y.,
RA   Huang Y., Liu J., Kang H., Chen J., Wang L., Chen A., Yu S., Gao Z.,
RA   Jin L., Gu W., Wang Z., Zhao L., Shi B., Wen H., Lin R., Jones M.K.,
RA   Brejova B., Vinar T., Zhao G., McManus D.P., Chen Z., Zhou Y., Wang S.;
RT   "The genome of the hydatid tapeworm Echinococcus granulosus.";
RL   Nat. Genet. 45:1168-1175(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center {ECO:0000256|RuleBase:RU363050}.
CC   -!- SIMILARITY: Belongs to the TUBGCP family.
CC       {ECO:0000256|ARBA:ARBA00010337, ECO:0000256|RuleBase:RU363050}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EUB62289.1}.
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DR   EMBL; APAU02000013; EUB62289.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6V767; -.
DR   STRING; 6210.W6V767; -.
DR   EnsemblMetazoa; XM_024491991.1; XP_024353485.1; GeneID_36338457.
DR   OMA; YTDDYWE; -.
DR   OrthoDB; 1328394at2759; -.
DR   Proteomes; UP000019149; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR   GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR   GO; GO:0007020; P:microtubule nucleation; IEA:InterPro.
DR   Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR   InterPro; IPR007259; GCP.
DR   InterPro; IPR040457; GCP_C.
DR   InterPro; IPR042241; GCP_C_sf.
DR   InterPro; IPR041470; GCP_N.
DR   PANTHER; PTHR19302; GAMMA TUBULIN COMPLEX PROTEIN; 1.
DR   PANTHER; PTHR19302:SF13; GAMMA-TUBULIN COMPLEX COMPONENT 2; 1.
DR   Pfam; PF04130; GCP_C_terminal; 1.
DR   Pfam; PF17681; GCP_N_terminal; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU363050};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW   ECO:0000256|RuleBase:RU363050};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU363050};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019149}.
FT   DOMAIN          249..557
FT                   /note="Gamma tubulin complex component protein N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17681"
FT   DOMAIN          561..968
FT                   /note="Gamma tubulin complex component C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04130"
FT   REGION          980..1070
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        992..1008
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1070 AA;  119248 MW;  DCB702B9C13F716D CRC64;
     MDAVKSAILH DTNELLQAIY GQPVDRAIVN TYADQLIKTI TPRSSSQKNV EQAKKVLLDG
     NPGGKAFLAK YNELKLKNIR ELDPLVYLLG KIKCDPELLR LLHNSDKECN DISDGSDYES
     FDQLQMRIQN SNTNAILGPL RPGDFTGLET DENLQQFHEN LGSVRDPQQL PHYYATYATA
     DRTEVTKSTL KPKESGSEYR KALRQFPQWM YEVFYLSSDF LPENLFTSKT PSILPLETLP
     LNVQEKLIVQ DLLACLQGSD GVYVKALKIK DPHAVRNFAI DEKMRTKMSC SLADPSLVDT
     VNKVVPMISQ YSLIVRFIEE KSRYEYGRVN QALCEAMEQF LQEYWKLLCQ LEAQYRANQL
     GISRLLLLLK ETSHLFSQLA QLATNINTGG CVGGATLSLL YEGLRGQVSV ISRVHDCLLY
     LLRSACRPFF DSLSFWLYRG FLRPDDAERG EFFIVKSSAL PLPSQENDAA RDYINSAYYW
     ERSYSILSTQ LPGFLESRAE KVLATGKYLN VVQQCDSSLQ LAEPEDLVFS ETENDFLTKI
     DRAHAFASRT LLDFILKQKD LKGILKSIKR YFLLDQGDFI VHFMDTAAAE LKKPISQVSI
     SGLNSLLEWV LQTSSAACDP YKDNLKVVST NCDLITQMLT LHVAADGSNV DTIIDMDPSA
     LEALSLDYKV EWPTALVINR PVIDRYQMLF RHLFYCRHVE RHLSTSWAMR KAVRRATAAG
     ALAFNNAFIL GQRMLTYIQN LQYYMTFEVL EPNWHSFFQF LNKADNLDEV LKAHERCLEI
     CMDDCLLTSP DLLALVGKLN AVCIQFANCL NRLADASLDD TLDSVPMSTA ASMHHRRGVT
     TDTGVAGAVS ASPSFTNLAL TSAPALPRGD RWRCGSMASS DGGSLFKAGD TTTSSSLAGS
     SLDMRRRVAA SDLGSIGSNE RFAIAVEDFG LKFNSLIVDL LVKIRRPVDR ERDKLLSLAA
     RLDFNGFYTR YSLDAVTRGS AVDGSLGSGS GLGSLPRPSS SMGSLATLEG LSTAPPRRLT
     AAGDEESAPP LATPQRPRKS AIPPPPQPRD RRHTTAHHLP PAPTSTMSEY
//