ID   W6ZA32_COCMI            Unreviewed;       688 AA.
AC   W6ZA32;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=ELMO domain-containing protein {ECO:0000259|PROSITE:PS51335};
GN   ORFNames=COCMIDRAFT_41115 {ECO:0000313|EMBL:EUC40571.1},
GN   COCMIDRAFT_8349 {ECO:0000313|EMBL:EUC42030.1};
OS   Bipolaris oryzae ATCC 44560.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX   NCBI_TaxID=930090 {ECO:0000313|EMBL:EUC40571.1};
RN   [1] {ECO:0000313|EMBL:EUC40571.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 44560 {ECO:0000313|EMBL:EUC40571.1};
RX   PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA   Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA   Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA   Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA   LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA   Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT   "Comparative genome structure, secondary metabolite, and effector coding
RT   capacity across Cochliobolus pathogens.";
RL   PLoS Genet. 9:E1003233-E1003233(2013).
CC   -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC       phagocytosis of apoptotic cells and cell motility. Acts in association
CC       with DOCK1 and CRK. Was initially proposed to be required in complex
CC       with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC       nucleotide exchange factor (GEF) activity of DOCK1.
CC       {ECO:0000256|ARBA:ARBA00024863}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KI964154; EUC40571.1; -; Genomic_DNA.
DR   EMBL; KI964076; EUC42030.1; -; Genomic_DNA.
DR   RefSeq; XP_007691454.1; XM_007693264.1.
DR   RefSeq; XP_007692903.1; XM_007694713.1.
DR   STRING; 930090.W6ZA32; -.
DR   GeneID; 19124000; -.
DR   GeneID; 19126268; -.
DR   KEGG; bor:COCMIDRAFT_41115; -.
DR   KEGG; bor:COCMIDRAFT_8349; -.
DR   eggNOG; KOG2999; Eukaryota.
DR   HOGENOM; CLU_009191_0_0_1; -.
DR   OrthoDB; 1473500at2759; -.
DR   Proteomes; UP000054032; Unassembled WGS sequence.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024574; ELMO_ARM.
DR   InterPro; IPR006816; ELMO_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR12771:SF56; CED-12; 1.
DR   PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR   Pfam; PF11841; ELMO_ARM; 1.
DR   Pfam; PF04727; ELMO_CED12; 1.
DR   Pfam; PF16457; PH_12; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS51335; ELMO; 1.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW   SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT   DOMAIN          238..410
FT                   /note="ELMO"
FT                   /evidence="ECO:0000259|PROSITE:PS51335"
FT   REGION          238..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   688 AA;  77097 MW;  24A0F7234C5E3CE9 CRC64;
     MDSVNVSELV ARLGAEEESV RKMAVFKLQN AIGDPSFADV FIYEGGLPKL RFLALHSTGN
     TLAYCLTSLA RLLELDKGWD HVTDDLIARI VDLVVAQPLV NVNRGAMSVL AVIVGHPSHR
     SSHTGTTGFQ RLKPAVDAQP QFLSSLVEKI TSADHALCAN SLQLINALMR DAIANDAAFE
     WPKFIKQLQE LGVIKSVYGL MQSTAIQDLA HPLLDFQTLT KTLLRNWREE KVDLENPDHR
     RAIRGLHTAS QPDRSSSDPK GSKKHHPEKW SRLGFETESP AWEFNGTGFL GLMDITDFVY
     KNEDGFQKLL LEQSAEPAEQ RCPIARASLS VTQTLYEHFE VDKLDDVEAL RHTDSRANFD
     RAFKPLLLHW SRLHTSGLNA FIRLWKAAGA QIEDFEKIEE LIRILIEQVV GQAPRMKDVK
     EIEEELAEFE LKRLRELQME VLELTYEDAW GHHLRQVRDE LNHEALQFVK EQRIRCLLQG
     AWFPMGADFG TNTGPVAGNR AVPSSWRFVR LSHNRRYLHY ADFNEKTAAE PKLDALQEKI
     DLSIVSSVVS NVSASAPSTA SSDSTVRTLP GHERASTSTK ITIHGYMALS NHARQTSSGS
     GAGRKESVLL HLHPQSHTLA SEWLDGLLML LNQQPITANT NKLVTFIGGY GLKIRLLNVR
     YEDVGLDEPV LPSREGLDDE YYYDIAGA
//