ID W7AEV3_PLAVN Unreviewed; 442 AA.
AC W7AEV3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=4-hydroxy-3-methylbut-2-enyl diphosphate reductase {ECO:0000313|EMBL:CAD2096199.1, ECO:0000313|EMBL:EUD70240.1};
DE EC=1.17.1.2 {ECO:0000313|EMBL:CAD2096199.1};
GN ORFNames=PVPCR_0200940 {ECO:0000313|EMBL:CAD2096199.1}, YYG_04556
GN {ECO:0000313|EMBL:EUD70240.1};
OS Plasmodium vinckei petteri.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX NCBI_TaxID=138298 {ECO:0000313|EMBL:EUD70240.1, ECO:0000313|Proteomes:UP000030659};
RN [1] {ECO:0000313|EMBL:EUD70240.1, ECO:0000313|Proteomes:UP000030659}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CR {ECO:0000313|EMBL:EUD70240.1,
RC ECO:0000313|Proteomes:UP000030659};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium vinckei petteri CR.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAD2096199.1, ECO:0000313|Proteomes:UP000515268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Ramaprasad A.;
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; LR865407; CAD2096199.1; -; Genomic_DNA.
DR EMBL; KI965406; EUD70240.1; -; Genomic_DNA.
DR AlphaFoldDB; W7AEV3; -.
DR EnsemblProtists; EUD70240; EUD70240; YYG_04556.
DR VEuPathDB; PlasmoDB:PVPCR_0200940; -.
DR eggNOG; ENOG502QPIQ; Eukaryota.
DR OrthoDB; 226678at2759; -.
DR Proteomes; UP000030659; Unassembled WGS sequence.
DR Proteomes; UP000515268; Chromosome PVPCR_02.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0051745; F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0050992; P:dimethylallyl diphosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0019288; P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:InterPro.
DR CDD; cd13944; lytB_ispH; 1.
DR Gene3D; 3.40.50.11270; -; 1.
DR Gene3D; 3.40.1010.20; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, catalytic domain; 2.
DR HAMAP; MF_00191; IspH; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR003451; LytB/IspH.
DR NCBIfam; TIGR00216; ispH_lytB; 1.
DR PANTHER; PTHR30426; 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE; 1.
DR PANTHER; PTHR30426:SF0; 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE; 1.
DR Pfam; PF02401; LYTB; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000313|EMBL:CAD2096199.1}.
SQ SEQUENCE 442 AA; 50280 MW; 0EF8C593A71BBADD CRC64;
MYGMLNVRSN FSIPTVTKWK NINKYGFVHK IGDYNYQKND KINIFRRSNS YAINYEFKVK
PFKAKKNKDI YFLGMQSNRN EKLNETKCGG GCGACSSQIN TNNFETNDST KNEDEKNDSK
ILYLINPRGF CKGVSRAIET VEECLKTFKT NIYVKHKIVH NDIVCKDLES KGAIFIEDLN
EVPDGSILIY SAHGISPQIR ELAKKKKLIE IDATCPLVNK VHVYVKLKEK EGYKIILIGY
KNHVEVVGTY NEAPDSTYIV ENVEQVNNLN FPENQKLFYV TQTTLSIDDC SLIVNKLKEK
YPHIETIPSG SICYATTNRQ KALNKICTEC DLTIVVGSQS SSNAKKLVYS SQIRNTDAIL
VNTVNDFDFS SLENVKKIAL TSAASTPDEL TQQFVKVLTN PPYNYKLSIF DGVEEIVPKW
KLPKELINMI KQKNEEETKP NS
//
