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Database: UniProt
Entry: W7AN61_PLAVN
LinkDB: W7AN61_PLAVN
Original site: W7AN61_PLAVN 
ID   W7AN61_PLAVN            Unreviewed;       498 AA.
AC   W7AN61;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=5-methylcytosine rRNA methyltransferase NSUN4 {ECO:0000256|ARBA:ARBA00040337};
DE   AltName: Full=5-methylcytosine tRNA methyltransferase NSUN4 {ECO:0000256|ARBA:ARBA00041914};
DE   AltName: Full=NOL1/NOP2/Sun domain family member 4 {ECO:0000256|ARBA:ARBA00042050};
GN   ORFNames=PVPCR_0900920 {ECO:0000313|EMBL:CAD2103711.1}, YYG_01728
GN   {ECO:0000313|EMBL:EUD72728.1};
OS   Plasmodium vinckei petteri.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX   NCBI_TaxID=138298 {ECO:0000313|EMBL:EUD72728.1, ECO:0000313|Proteomes:UP000030659};
RN   [1] {ECO:0000313|EMBL:EUD72728.1, ECO:0000313|Proteomes:UP000030659}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CR {ECO:0000313|EMBL:EUD72728.1,
RC   ECO:0000313|Proteomes:UP000030659};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium vinckei petteri CR.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CAD2103711.1, ECO:0000313|Proteomes:UP000515268}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Ramaprasad A.;
RL   Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a cytidine in rRNA + S-adenosyl-L-methionine = a 5-
CC         methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:61484, Rhea:RHEA-COMP:15836, Rhea:RHEA-COMP:15837,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74483, ChEBI:CHEBI:82748;
CC         Evidence={ECO:0000256|ARBA:ARBA00036484};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a cytidine in tRNA + S-adenosyl-L-methionine = a 5-
CC         methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:61468, Rhea:RHEA-COMP:13670, Rhea:RHEA-COMP:15827,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74483, ChEBI:CHEBI:82748;
CC         Evidence={ECO:0000256|ARBA:ARBA00036266};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR   EMBL; LR865414; CAD2103711.1; -; Genomic_DNA.
DR   EMBL; KI965397; EUD72728.1; -; Genomic_DNA.
DR   AlphaFoldDB; W7AN61; -.
DR   EnsemblProtists; EUD72728; EUD72728; YYG_01728.
DR   VEuPathDB; PlasmoDB:PVPCR_0900920; -.
DR   eggNOG; KOG2198; Eukaryota.
DR   OrthoDB; 317522at2759; -.
DR   Proteomes; UP000030659; Unassembled WGS sequence.
DR   Proteomes; UP000515268; Chromosome PVPCR_09.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR   GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR001678; MeTrfase_RsmB/NOP2.
DR   InterPro; IPR023267; RCMT.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR22808:SF3; 5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4; 1.
DR   PANTHER; PTHR22808; NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR   Pfam; PF01189; Methyltr_RsmB-F; 1.
DR   PRINTS; PR02008; RCMTFAMILY.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW   ProRule:PRU01023}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU01023};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PROSITE-ProRule:PRU01023};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU01023}.
FT   DOMAIN          111..421
FT                   /note="SAM-dependent MTase RsmB/NOP-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51686"
FT   ACT_SITE        368
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT   BINDING         202..208
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT   BINDING         262
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT   BINDING         314
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ   SEQUENCE   498 AA;  57483 MW;  A916D4C79E4BB13E CRC64;
     MKCSGKVGYF LNLKKEYGDR AEVLMKKLEE GKTVQAAFIN DFIKIDYINI FKVLLYMIKD
     KKVKTSFGGL FVDEKYANLL TYFATSENNN NLSYEIITQN SCKHNENCDS VNVASQLDGG
     TIVQYNTSDE NAKSGLYEKT ESNGDYRKIT ISKSELLNID GVIKYDGMIE NVEKLAYYLN
     PCSFLSAYFL DVKKNEHVLD MCAAPGGKSL IIANKLFGFD ISPLDRINNI NILDDKNIEI
     NCCLNVLNYY KVNREGCLVV NEFNKARYDR LKQVLHKHLP SDLIKSGNLH ITNYNGLQLN
     SFIRFQKFHK ILLDVPCSTD EHLIKKGTND INKWTFNSIK NNSNIQYDLL VNSFHLLHKN
     GVIIYSTCAL SHYENDYNIE RFIKKFKKEV KILDFLEEEY ERVYKEKIMN NHTIENDSHM
     PCHCKMETPD NSTNHANHNV SCTSHTNNDA SCTNTKNFSE FKKNTNFLKF FEKTKYGYIS
     LPDKSPFGIL YICKIKKI
//
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