ID W7D5J3_9LIST Unreviewed; 969 AA.
AC W7D5J3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BCAMP_04894 {ECO:0000313|EMBL:EUJ40543.1};
OS Brochothrix campestris FSL F6-1037.
OC Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Brochothrix.
OX NCBI_TaxID=1265861 {ECO:0000313|EMBL:EUJ40543.1, ECO:0000313|Proteomes:UP000019243};
RN [1] {ECO:0000313|EMBL:EUJ40543.1, ECO:0000313|Proteomes:UP000019243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSL F6-1037 {ECO:0000313|EMBL:EUJ40543.1,
RC ECO:0000313|Proteomes:UP000019243};
RA den Bakker H.C., Allred A., Warchocki S., Wright E.M., Burrell A.,
RA Nightingale K.K., Kephart D., Wiedmann M.;
RT "Novel taxa of Listeriaceae from agricultural environments in the United
RT States.";
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00560}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUJ40543.1}.
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DR EMBL; AODH01000017; EUJ40543.1; -; Genomic_DNA.
DR AlphaFoldDB; W7D5J3; -.
DR STRING; 1265861.BCAMP_04894; -.
DR PATRIC; fig|1265861.3.peg.967; -.
DR Proteomes; UP000019243; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014152; AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02785; addA_Gpos; 1.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000019243}.
FT DOMAIN 1..220
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 243..543
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
SQ SEQUENCE 969 AA; 109729 MW; DB338DED1F80647E CRC64;
MLTIVKDQSF AAMQAILATL KFGRAPAVKK DDEVDREAIK QIASLRDDAK KQMKDLTEKW
CQRTAESFLS DFDILRPQVE KLGDIVQQFL AAYQVAKRKR AVLDFSDLEH YAIELLGTPD
AQGVFHPTEI AAHYRQKFAE VYTDEYQDTN KVQETLLSLV AQPEGTDSGG NRFIVGDVKQ
SIYRFRLAEP ELFIDKYQRY PTTAGPTGYR IDLSQNFRSR SNIIKTTNAL FAQLMDERFG
EIAYDEDAAL KLGASYPPLP GNEAAQLAAE ATEIILVEGD FKTDELEPET YVGSNHEKEA
EIVARRIKAL KEEKYQVYDG KKGAYREIDY KDIVILARSM TQADIYERVF QKYELPLYAT
TNNGYFESIE VMTMMAVLKV IDNPYQDIPL AAVLRSAIVG LSEEELAQIR LADTKGYFFD
ALRADVAETS PYQAKLALFV ERLERWRQQA HQATTAELIW QIYEESMYYD YVGGLIGGRQ
RQANLRALYD RANQYEQTSF RGLFRFIRFI DRLQVKGKDL GTAKSLGEND NVVRMMTIHK
SKGLEFPVVF VVGLGKGFNR QDINSAELVD KTYGFASVLT QLETRTKQPT IAQYAFRCKQ
LKELQAEEMR VLYVALTRAE EKLILVGSCK QYAKTMTKWA STRHFSDIVL PEYIRSSAMT
YLDWIGYAFS RDASFVAFSG ADVDGRNYPM DETPIISWQK EDTLITKDSV AQSSSHDWLM
AAQTATPLEA VDVSLAVSTL LDYQYESQEA TGIPSKTSVT EVKRRLAERE LAESAPYGEE
LTPISLERPK FLQAKKLQAN EIGTAMHSVM QQVPLTTTPT LASIATLLEA LVAKKIMTQA
EVNVINVEAI VAFFASDLGR LVLTHRTRRE VPFMYLIDAS DVYETQTNDQ TIVQGIVDCL
IETEAGLIII DYKTDRIVGD WIEVEETYRE KYRVQLALYA KAIEAASNRP VIAKYLYFFD
GGHVSEVSA
//
