ID W7EZV8_PLAF8 Unreviewed; 1458 AA.
AC W7EZV8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=TKL protein kinase {ECO:0000313|EMBL:EUR70667.1};
GN ORFNames=PFBG_03232 {ECO:0000313|EMBL:EUR70667.1};
OS Plasmodium falciparum (isolate 7G8).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57266 {ECO:0000313|EMBL:EUR70667.1, ECO:0000313|Proteomes:UP000030688};
RN [1] {ECO:0000313|Proteomes:UP000030688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7G8 {ECO:0000313|Proteomes:UP000030688};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Daily J.P., Sarr O., Ndiaye D., Ndir O., Mboup S., Lukens A.,
RA Stange-Thomann N., Mauceli E., Gnerre S., Jaffe D., Zainoun J.,
RA Wiegand R.C., Birren B., Galagan J., Lander E., Wirth D.F.;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EUR70667.1, ECO:0000313|Proteomes:UP000030688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7G8 {ECO:0000313|EMBL:EUR70667.1,
RC ECO:0000313|Proteomes:UP000030688};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum 7G8.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE123622; EUR70667.1; -; Genomic_DNA.
DR EnsemblProtists; EUR70667; EUR70667; PFBG_03232.
DR Proteomes; UP000030688; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR44329:SF293; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE; 1.
DR PANTHER; PTHR44329; SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:EUR70667.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000313|EMBL:EUR70667.1}.
FT DOMAIN 301..366
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1055..1440
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 203..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 400..427
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 203..221
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..644
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1458 AA; 171707 MW; 5A3CF15E19273A70 CRC64;
MGNTLDSNKP KNFVTYADYK YIGKLNNKNE HHGIGIILYN SGESFYGSFI NGKKEGKGIY
IDKNLTRYIN TWVDNKVFGK VKVVPYNSNR VYYFYYKNYM IEKCIYFDNN INNKESHHKN
NIYNNYDNNS YNNNSCDDEE KRKYPIGVTK FKEDLSNYIH STHIMKKNNK LFNKNDNEYN
IFSSSLSYSS DSENINLLDI LKKKKNKKNK KNKKKKNKKT KNTQILSCTQ HKMYEHNMNE
SNFTKKDNVN CEHTDKMNIS LHEKNDKKNE KKNEKKNKKK KLFKYFSNNI ENLIIENYQT
WSLREVIQWL MLCNVPVKWL ISFYKNNITG DKLKYININT IRNELGIIAY GHAIKILQLI
KNLQVMAYNK KFNNLIQIEE YKNYIRQKEN TNKNIKKGKN IKKEKNIKKE KKKKKKETKK
FNNMDKKYID LAIHKNVKNI QNDTFYNKHE NIYNCKNQTN FIYQNDSEIK KIMNKKKVSF
EYDNNEEKKK KNIIKFIKNN KSLQNSNGEY YLINHLSKGI CSDSIFYKSS QSKSSSQLSS
PLSSPLSSPS SSPSSSSSSP SSSPSSPPSP LSYKDNFPIS SSCSSLERLP SYEKKLLSSS
QSNIEHIKNL PLDVLSNNNS SANIKIKKSK SKYNNDKKEQ KKLPLILNKS SSEFSPSHSY
TSKSYHYNIK PSLQSSSNNS SDSSYSISST CSSSSSYVSS LYSNRSNDIL NFYRNKIIKY
CNNIYMNTKL AYSYMNGFII PHEDLIFIHP IENYYMDNTN EKNNINNPYT KEKIMNHNFS
FNTKNNTSFI DINTNIFSSN KQQNINNFGK YKKMKSRMFK GKYMGKEVAI KILVGKIKNF
KKLHQILYNL YNLRHSNLVL IMGVSIHYPF VFIIYEYMKN KCLFSYLHCI KYKHVYISTF
LQRYKTLLHI TQQEKIKKTN NINNNNNINH NNINNNNINH NNINHNNINN NNINNNNINY
NKDYNNKKKK EDEQHNIEHQ DTFIDLPEKS NISSDDNNST DISQIQKENF HFLNKKIEEN
KNIIYDDHTS TLSDHSIHNI NKSYDNVYKN KMNIFHYQHN VLCGAYDNND NNINDNDIYC
NNIYDNNIND NHIYCNNIND NHIYCNNIYD HHKNTSLNSK EQNTDHNIEQ INECNKYASE
TKYNIKKSNL KNNIISHKNF QKCNQIQMNQ PYTFPPYQKE LSSYLKNEKI KRKRKVLFSY
LKTHIHFNSQ QINDQHNRLS VQKIMKIITD VTLACTYLEK EKMSPINLKP TNILLDESLN
AKISDFGISK IENCLDMNID YSYKISSNSV IKINKKEYEQ KKAKKIKIVN KNNNDLLYLY
DHNNNVYKYN TQYIDVTYNN SYPSIFYWTP PEILRGKKNK KFYSDIYAFG IILWEMLSND
IPYNYPFASH IMAVVGYANE ELSFNNIPVS IQSLIKACVN RNKYKRPTFE HILKTISTLY
QKANTKVEDA LISFMDGT
//
