ID W7FEM4_PLAF8 Unreviewed; 627 AA.
AC W7FEM4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 08-NOV-2023, entry version 45.
DE RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
GN ORFNames=PFBG_05338 {ECO:0000313|EMBL:EUR63590.1};
OS Plasmodium falciparum (isolate 7G8).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57266 {ECO:0000313|EMBL:EUR63590.1, ECO:0000313|Proteomes:UP000030688};
RN [1] {ECO:0000313|Proteomes:UP000030688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7G8 {ECO:0000313|Proteomes:UP000030688};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Daily J.P., Sarr O., Ndiaye D., Ndir O., Mboup S., Lukens A.,
RA Stange-Thomann N., Mauceli E., Gnerre S., Jaffe D., Zainoun J.,
RA Wiegand R.C., Birren B., Galagan J., Lander E., Wirth D.F.;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EUR63590.1, ECO:0000313|Proteomes:UP000030688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7G8 {ECO:0000313|EMBL:EUR63590.1,
RC ECO:0000313|Proteomes:UP000030688};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum 7G8.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE123644; EUR63590.1; -; Genomic_DNA.
DR AlphaFoldDB; W7FEM4; -.
DR SMR; W7FEM4; -.
DR EnsemblProtists; EUR63590; EUR63590; PFBG_05338.
DR VEuPathDB; PlasmoDB:Pf7G8_140035400; -.
DR Proteomes; UP000030688; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd05471; pepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 3.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR034164; Pepsin-like_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR Pfam; PF00026; Asp; 2.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2}.
FT DOMAIN 228..605
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 246
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 495
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 259..264
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 627 AA; 74183 MW; 3F838C4676AD4280 CRC64;
MFFINFKKIK KKQFPIYLTQ HRIITVFLIF IYFINLKDCF HINNSRILSD VDKHRGLYYN
IPKCNVCHKC SICTHENGEA QNVIPMVAIP SKRKHIQDIN KEREENKYPL HIFEEKDIYN
NKDNVVKKED IYKLRKKKKQ KKNCLNFLEK DTMFLSPSHD KETFHINHMN KIKDEKYKQE
YEEEKEIYDN TNTSQEKNET NNEQNLNINL INNDKVTLPL QQLEDSQYVG YIQIGTPPQT
IRPIFDTGST NIWIVSTKCK DETCLKVHRY NHKLSSSFKY YEPHTNLDIM FGTGIIQGVI
GVETFKIGPF EIKNQSFGLV KREKASDNKS NVFERINFEG IVGLAFPEML STGKSTLYEN
LMSSYKLQHN EFSIYIGKDS KYSALIFGGV DKNFFEGDIY MFPVVKEYYW EIHFDGLYID
HQKFCCGVNS IVYDLKKKDQ ENNKLFFTRK YFRKNKFKTH LRKYLLKKIK HQKKQKHSNH
KKKKLNKKKN YLIFDSGTSF NSVPKDEIEY FFRVVPSKKC DDSNIDQVVS SYPNLTYVIN
KMPFTLTPSQ YLVRKNDMCK PAFMEIEVSS EYGHAYILGN ATFMRYYYTV YRRGNNNNSS
YVGIAKAVHT EENEKYLSSL HNKINNL
//