GenomeNet

Database: UniProt
Entry: W7FEM4_PLAF8
LinkDB: W7FEM4_PLAF8
Original site: W7FEM4_PLAF8 
ID   W7FEM4_PLAF8            Unreviewed;       627 AA.
AC   W7FEM4;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   08-NOV-2023, entry version 45.
DE   RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
GN   ORFNames=PFBG_05338 {ECO:0000313|EMBL:EUR63590.1};
OS   Plasmodium falciparum (isolate 7G8).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=57266 {ECO:0000313|EMBL:EUR63590.1, ECO:0000313|Proteomes:UP000030688};
RN   [1] {ECO:0000313|Proteomes:UP000030688}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=7G8 {ECO:0000313|Proteomes:UP000030688};
RG   The Broad Institute Genome Sequencing Platform;
RA   Volkman S.K., Daily J.P., Sarr O., Ndiaye D., Ndir O., Mboup S., Lukens A.,
RA   Stange-Thomann N., Mauceli E., Gnerre S., Jaffe D., Zainoun J.,
RA   Wiegand R.C., Birren B., Galagan J., Lander E., Wirth D.F.;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EUR63590.1, ECO:0000313|Proteomes:UP000030688}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=7G8 {ECO:0000313|EMBL:EUR63590.1,
RC   ECO:0000313|Proteomes:UP000030688};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum 7G8.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KE123644; EUR63590.1; -; Genomic_DNA.
DR   AlphaFoldDB; W7FEM4; -.
DR   SMR; W7FEM4; -.
DR   EnsemblProtists; EUR63590; EUR63590; PFBG_05338.
DR   VEuPathDB; PlasmoDB:Pf7G8_140035400; -.
DR   Proteomes; UP000030688; Unassembled WGS sequence.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd05471; pepsin_like; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 3.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR034164; Pepsin-like_dom.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR   Pfam; PF00026; Asp; 2.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2}.
FT   DOMAIN          228..605
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        246
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        495
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        259..264
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   627 AA;  74183 MW;  3F838C4676AD4280 CRC64;
     MFFINFKKIK KKQFPIYLTQ HRIITVFLIF IYFINLKDCF HINNSRILSD VDKHRGLYYN
     IPKCNVCHKC SICTHENGEA QNVIPMVAIP SKRKHIQDIN KEREENKYPL HIFEEKDIYN
     NKDNVVKKED IYKLRKKKKQ KKNCLNFLEK DTMFLSPSHD KETFHINHMN KIKDEKYKQE
     YEEEKEIYDN TNTSQEKNET NNEQNLNINL INNDKVTLPL QQLEDSQYVG YIQIGTPPQT
     IRPIFDTGST NIWIVSTKCK DETCLKVHRY NHKLSSSFKY YEPHTNLDIM FGTGIIQGVI
     GVETFKIGPF EIKNQSFGLV KREKASDNKS NVFERINFEG IVGLAFPEML STGKSTLYEN
     LMSSYKLQHN EFSIYIGKDS KYSALIFGGV DKNFFEGDIY MFPVVKEYYW EIHFDGLYID
     HQKFCCGVNS IVYDLKKKDQ ENNKLFFTRK YFRKNKFKTH LRKYLLKKIK HQKKQKHSNH
     KKKKLNKKKN YLIFDSGTSF NSVPKDEIEY FFRVVPSKKC DDSNIDQVVS SYPNLTYVIN
     KMPFTLTPSQ YLVRKNDMCK PAFMEIEVSS EYGHAYILGN ATFMRYYYTV YRRGNNNNSS
     YVGIAKAVHT EENEKYLSSL HNKINNL
//
DBGET integrated database retrieval system