ID   W7FN36_PLAF8            Unreviewed;       554 AA.
AC   W7FN36;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   13-SEP-2023, entry version 37.
DE   SubName: Full=4-hydroxy-3-methylbut-2-enyl diphosphate reductase {ECO:0000313|EMBL:EUR82697.1};
GN   ORFNames=PFBG_00042 {ECO:0000313|EMBL:EUR82697.1};
OS   Plasmodium falciparum (isolate 7G8).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=57266 {ECO:0000313|EMBL:EUR82697.1, ECO:0000313|Proteomes:UP000030688};
RN   [1] {ECO:0000313|Proteomes:UP000030688}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=7G8 {ECO:0000313|Proteomes:UP000030688};
RG   The Broad Institute Genome Sequencing Platform;
RA   Volkman S.K., Daily J.P., Sarr O., Ndiaye D., Ndir O., Mboup S., Lukens A.,
RA   Stange-Thomann N., Mauceli E., Gnerre S., Jaffe D., Zainoun J.,
RA   Wiegand R.C., Birren B., Galagan J., Lander E., Wirth D.F.;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EUR82697.1, ECO:0000313|Proteomes:UP000030688}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=7G8 {ECO:0000313|EMBL:EUR82697.1,
RC   ECO:0000313|Proteomes:UP000030688};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum 7G8.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR   EMBL; KE123575; EUR82697.1; -; Genomic_DNA.
DR   AlphaFoldDB; W7FN36; -.
DR   EnsemblProtists; EUR82697; EUR82697; PFBG_00042.
DR   Proteomes; UP000030688; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0051745; F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0050992; P:dimethylallyl diphosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0019288; P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway; IEA:InterPro.
DR   CDD; cd13944; lytB_ispH; 1.
DR   CDD; cd02257; Peptidase_C19; 1.
DR   Gene3D; 3.40.50.11270; -; 1.
DR   Gene3D; 3.40.1010.20; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, catalytic domain; 2.
DR   HAMAP; MF_00191; IspH; 1.
DR   InterPro; IPR003451; LytB/IspH.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   NCBIfam; TIGR00216; ispH_lytB; 1.
DR   PANTHER; PTHR30426; 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE; 1.
DR   PANTHER; PTHR30426:SF0; 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE; 1.
DR   Pfam; PF02401; LYTB; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
SQ   SEQUENCE   554 AA;  64126 MW;  815F5C3E41F22D22 CRC64;
     MRRKRSILQI FENSIKSKEG KCNFTKRYIT HYYNIPLKIK KHDLPSVIKY FSHKPNGKHN
     YVTNMITQKN RKSFLFFFFL YNKYFFGKQE QIRKMNYHEE MNKINIKNDG NRKIYMYPKN
     DIHEEDGDHK NDVEINQKRN EQNCKSFNDE KNENARDPNK ILYLINPRGF CKGVSRAIET
     VEECLKLFKP PIYVKHKIVH NDIVCKKLEK EGAIFIEDLN DVPDGHILIY SAHGISPQIR
     EIAKKKKLIE IDATCPLVNK VHVYVQMKAK ENYDIILIGY KNHVEVIGTY NEAPHCTHIV
     ENVNDVDKLN FPLNKKLFYV TQTTLSMDDC ALIVQKLKNK FPHIETIPSG SICYATTNRQ
     TALNKICTKC DLTIVVGSSS SSNAKKLVYS SQIRNVPAVL LNTVHDLDQQ ILKNVNKIAL
     TSAASTPEQE TQKFVNLLTN PPFNYTLQNF DGAHENTHVK INSKIVVNNF DYKLYGAIIH
     GGISASSGHY YFIGKKSERQ NKKKSSWYQM NDSVVTKANS KMINKISKDL SNDHTPYVLF
     YRCKQAPISP DLYF
//